HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
methyl 1- (5- fluoro- 1H- 2- oxopyrimidin- 4- yl)- beta- D- glucopyranuronate
structure
Also Known As:
FU-O-G; methyl (5-fluoro-1H-2-oxo-4-pyrimidinyl beta-D-glucopyranoside)uronate
Networked:
2
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidinones: 71
Uracil: 1493
Fluorouracil: 26711
methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D- glucopyranuronate: 2
Pyrimidine Nucleosides: 50
methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D- glucopyranuronate: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Pyrimidine Nucleosides: 50
methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D- glucopyranuronate: 2
Related Diseases
1.
Neoplasms (Cancer)
09/01/1984 - "
In this study, long-term administration of FU-O-G to mice bearing relatively slow-growing tumors such as Lewis lung carcinoma, mammary tumor FM3 A and hepatoma MH-134 was carried out.
"
09/01/1984 - "
Consequently, FU-O-G was shown to be remarkably effective against those tumors, whereas 5-FU and FT-207 were hardly effective.
"
04/01/1981 - "
These findings correspond with the results of an enzymological study which showed selective activation of FU-O-G by beta-glucosidase in tumor cells and indicated that the compound is a marked form of 5-FU.
"
2.
Lewis Lung Carcinoma
09/01/1984 - "
In this study, long-term administration of FU-O-G to mice bearing relatively slow-growing tumors such as Lewis lung carcinoma, mammary tumor FM3 A and hepatoma MH-134 was carried out.
"
04/01/1981 - "
Furthermore, in the treatment of Lewis lung carcinoma, which responds poorly to 5-FU and Ftorafur, daily administration of FU-O-G at a dose of 400 mg/kg for 30 days produced a 92% increase in life span without marked loss of body weight, though short-term administration (such as 5 days) was barely effective.
"
09/01/1984 - "
In combination therapies of FU-O-G with other antitumor drugs, FU-O-G exhibited a synergistic effect against Lewis lung carcinoma when combined with Carboquone (CQ) or Nimustine hydrochloride (ACNU).
"
3.
Hepatocellular Carcinoma (Hepatoma)
09/01/1984 - "
In this study, long-term administration of FU-O-G to mice bearing relatively slow-growing tumors such as Lewis lung carcinoma, mammary tumor FM3 A and hepatoma MH-134 was carried out.
"
4.
Body Weight (Weight, Body)
04/01/1981 - "
Furthermore, in the treatment of Lewis lung carcinoma, which responds poorly to 5-FU and Ftorafur, daily administration of FU-O-G at a dose of 400 mg/kg for 30 days produced a 92% increase in life span without marked loss of body weight, though short-term administration (such as 5 days) was barely effective.
"
Related Drugs and Biologics
1.
Fluorouracil (Carac)
2.
Tegafur
3.
beta-Glucosidase
4.
Nimustine
5.
Carbazilquinone (Carboquone)
6.
Antineoplastic Agents (Antineoplastics)
Related Therapies and Procedures
1.
Therapeutics