methyl 1- (5- fluoro- 1H- 2- oxopyrimidin- 4- yl)- beta- D- glucopyranuronate

structure

Also Known As:

FU-O-G; methyl (5-fluoro-1H-2-oxo-4-pyrimidinyl beta-D-glucopyranoside)uronate

Networked: 2 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        Fluorouracil: 26711
        methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D- glucopyranuronate: 2
    - Pyrimidine Nucleosides: 50
      - methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D- glucopyranuronate: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D- glucopyranuronate: 2

Related Diseases

1.	Neoplasms (Cancer) 09/01/1984 - "In this study, long-term administration of FU-O-G to mice bearing relatively slow-growing tumors such as Lewis lung carcinoma, mammary tumor FM3 A and hepatoma MH-134 was carried out. " 09/01/1984 - "Consequently, FU-O-G was shown to be remarkably effective against those tumors, whereas 5-FU and FT-207 were hardly effective. " 04/01/1981 - "These findings correspond with the results of an enzymological study which showed selective activation of FU-O-G by beta-glucosidase in tumor cells and indicated that the compound is a marked form of 5-FU."
2.	Lewis Lung Carcinoma 09/01/1984 - "In this study, long-term administration of FU-O-G to mice bearing relatively slow-growing tumors such as Lewis lung carcinoma, mammary tumor FM3 A and hepatoma MH-134 was carried out. " 04/01/1981 - "Furthermore, in the treatment of Lewis lung carcinoma, which responds poorly to 5-FU and Ftorafur, daily administration of FU-O-G at a dose of 400 mg/kg for 30 days produced a 92% increase in life span without marked loss of body weight, though short-term administration (such as 5 days) was barely effective. " 09/01/1984 - "In combination therapies of FU-O-G with other antitumor drugs, FU-O-G exhibited a synergistic effect against Lewis lung carcinoma when combined with Carboquone (CQ) or Nimustine hydrochloride (ACNU)."
3.	Hepatocellular Carcinoma (Hepatoma) 09/01/1984 - "In this study, long-term administration of FU-O-G to mice bearing relatively slow-growing tumors such as Lewis lung carcinoma, mammary tumor FM3 A and hepatoma MH-134 was carried out. "
4.	Body Weight (Weight, Body) 04/01/1981 - "Furthermore, in the treatment of Lewis lung carcinoma, which responds poorly to 5-FU and Ftorafur, daily administration of FU-O-G at a dose of 400 mg/kg for 30 days produced a 92% increase in life span without marked loss of body weight, though short-term administration (such as 5 days) was barely effective. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Tegafur
3.	beta-Glucosidase
4.	Nimustine
5.	Carbazilquinone (Carboquone)
6.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Therapeutics