glucose-regulated proteins

03/01/2014 - "To study the role of GRP94 in maintaining liver homeostasis and tumor development, we created two liver-specific knockout mouse models with the deletion of Grp94 alone, or in combination with Pten, using the albumin-cre system. "
03/15/2012 - "In conclusion, this study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers."
04/01/2011 - "The aim of this study is to investigate the role of GRP75 on the resistant mechanisms of cancer cells by downregulating GRP75 expreesion via RNAi approach. "
09/01/2005 - "This study examined the involvement of GRP94 in radio-resistance in human cervical cancer cells. "
01/01/2015 - "We performed immunohistochemical staining for HSP90α, HSP90β, GRP94 and TRAP1 in 117 tumors and found that HSP90α and HSP90β were positive in 11 (9%) and 61 tumors (52%), respectively, most of which showed weak expression, whereas GRP94 and TRAP1 were positive in 115 (98%) and 117 tumors (100%), respectively, the majority of which showed moderate or strong expression. "

02/01/2013 - "Two characteristic chaperones of the UPR, GRP78, and GRP94, also responded positively to anoxia with strong increases in both the transcript and protein levels. "
10/01/2013 - "Inhibition of either CypD, IP3R1, or Grp75 decreased protein interaction within the complex, attenuated mitochondrial Ca(2+) overload, and protected cells from hypoxia-reoxygenation. "
01/03/2005 - "Three putative hypoxia responsive elements (HRE) were found in the GRP94 promoter. "
08/01/2003 - "Here, we report that expression of GRP94 was increased in human neuroblastoma cells (SH-SY5Y (SY5Y) cells) exposed to hypoxia/reoxygenation (H/R). "
06/01/2009 - "Western blot analyses showed changes within the first hour of anoxia; multiple stress proteins (Hsp72, Grp94, Hsp60, Hsp27, and HO-1) increased while apoptotic regulators (Bcl-2 and Bax) decreased. "

06/01/2015 - "In addition, primary TM cells obtained from glaucoma donors demonstrated increased ER stress markers including increased GRP78, GRP94, ATF-4, ERO-1α, and CHOP compared to normal TM cells. "
11/23/2012 - "General Hsp90 inhibitors and a selective Grp94 inhibitor also facilitate clearance of mutant myocilin, suggesting that therapeutic approaches aimed at inhibiting Grp94 could be beneficial for patients suffering from some cases of myocilin glaucoma."
12/15/2014 - "Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma."
11/23/2012 - "Treating glaucoma could be possible by inhibiting Grp94 and reducing its novel client, mutant myocilin. "

10/01/2009 - "From normal brain lysates, only heat shock cognate (HSC)70, GRP75, and HSP110 bind to HspBP1. "
01/01/2002 - "heat shock and glucose regulated proteins, their regulation, compartmentalization and family members. "
04/06/2001 - "Binding of antigenic peptide to the endoplasmic reticulum-resident protein gp96/GRP94 heat shock chaperone occurs in higher order complexes. "
04/21/1998 - "VSV8 binding to GRP94 was stimulated 2-fold or 4-fold, respectively, following chemical denaturation/renaturation or transient heat shock. "
11/17/1995 - "While hypoxic exposure of other cell types induces heat shock and glucose-regulated proteins, EC preferentially up-regulate HAPs. "

03/01/1999 - "This study investigates the expression pattern of GRP94 and GRP78 in a panel of breast carcinoma cell lines, as compared to two independently derived normal human breast epithelial cell lines. "
01/01/2014 - "It is overexpressed in some gastric and other gastrointestinal carcinomas, but little is known about the physiological role of GRP94 in gastric mucosa. "
09/01/2013 - "High levels of GRP94 expression (2+ or 3+) were observed in 109 of 130 gastric carcinomas (83.85%) by immunohistochemistry, and in 13 of 18 tumour specimens (72.22%) with Western blot analysis. "
09/01/2013 - "Involvement of ER-α36 in the malignant growth of gastric carcinoma cells is associated with GRP94 overexpression."
06/01/2011 - "GRP78 expression was negatively correlated with lymphatic invasion or low GRP94 expression of the carcinomas (P<0.05), while there was no correlation of GRP94 expression with other parameters of carcinomas (P>0.05). "