ethidium homodimer

structure

Also Known As:

4,7-diazadecyl-5,5'-bis(3,8-diamino-6-phenylphenanthridium) dichloride dihydrochloride; EthD-1; ethidium homodimer-1; 5,5'- (1,2-ethanediylbis(imino-3,1-propanediyl))bis(3,8-diamino-6-phenylphenanthridinium) dichloride di hydrochloride

Networked: 31 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenanthridines: 3
      - Ethidium: 622
        ethidium homodimer: 31

Experts

1.	Balling, Eva: 1 article (10/2022)
2.	Boedtkjer, Ebbe: 1 article (10/2022)
3.	Christiansen, Peer M: 1 article (10/2022)
4.	Dabir, Parag D: 1 article (10/2022)
5.	Dam, Vibeke S: 1 article (10/2022)
6.	Hauerslev, Katrine R: 1 article (10/2022)
7.	Henningsen, Mikkel B: 1 article (10/2022)
8.	Johansen, Tonje: 1 article (10/2022)
9.	McWhan, Kezia: 1 article (10/2022)
10.	Mele, Marco: 1 article (10/2022)

Related Diseases

1.	Necrosis 11/01/2019 - "Only 50% stretch increased LDH release and ethidium homodimer staining, suggesting the induction of necrosis. " 01/01/2014 - "GZA preserved renal function after IRI and reduced tubular necrosis and neutrophil infiltration by histological analyses and ethidium homodimer staining. " 11/01/2013 - "Using ethidium homodimer perfusion to assess necrosis in vivo, necrosis was abrogated in RIPK3(-/-) kidneys postischemia. " 02/23/2007 - "Here, we describe a novel technique for evaluating necrosis of epithelial cells in the proximal tubule that involves perfusing ethidium homodimer through the intact rat kidney. " 02/23/2007 - "A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer."
2.	Hyperthermia 01/01/2020 - "The efficacy of magnetic hyperthermia therapy was evaluated by using the cell viability test through the following fluorescence staining: calcein acetoxymethyl ester (492/513nm), for live cells, and ethidium homodimer-1 (526/619nm) for dead cells dyes. "
3.	Infections 02/01/2002 - "In cultures of both mouse and human central nervous system (CNS) cells, rVSV inoculations resulted in productive infection, expression of the G-GFP fusion protein in the dendritic and somatic plasma membrane, and death of all neurons and glia, as detected by ethidium homodimer nuclear staining. " 06/01/1997 - "Staining with the fluorescent probe ethidium homodimer-1 revealed that keratinocyte membranes were rapidly damaged upon infection with adherent streptococci but were not damaged by nonadherent streptococci. " 03/01/2010 - "The ratio of dead cells (determined by trypan blue or ethidium homodimer staining) to cells that stain with antibody to the major capsid protein VP5 (indicative of productive infection) was 1.8-4.1 for different melanoma cultures at 24-72 h post-infection. "
4.	Neoplasms (Cancer) 01/01/2019 - "The luminescence tracking properties of Eu3+-doped (red emission) and Tb3+-doped (green emission) NPs were successfully characterized by co-encapsulating with genetically modified cancer cell lines expressing green or red fluorescent proteins (GFP and RFP) in addition to a mixed population of live and dead cells stained with ethidium homodimer. " 04/01/1998 - "Lysine-directed conjugation of ethidium homodimer to B72.3 antibody: retention of immunoreactivity but altered tumor targeting."
5.	Cysts 12/13/2019 - "Fluorescent-dye staining in untreated 1BU trophozoites/cysts was negligible, but using antiamoebic agents, there was 59.3%-100% trypan blue, 100% Hoechst 33342, 0%-75.3% calcein-AM, and 100% ethidium homodimer-1 positivity. " 12/01/2019 - "Staining with fluorescein isothiocyanate-conjugated annexin V and ethidium homodimer III revealed photodynamic antimicrobial therapy induced apoptosis and necrosis in trophozoites dependent upon the intensity of treatment, whereas apoptosis was the predominant form of cell death in cysts. "

Related Drugs and Biologics

1.	Coloring Agents (Dyes)
2.	calcein AM
3.	Superoxides (Superoxide)
4.	Superoxide Dismutase-1
5.	Annexin A5
6.	Fluorescein-5-isothiocyanate (FITC)
7.	Trypan Blue
8.	Proteins (Proteins, Gene)
9.	Fluorescent Dyes (Fluorescent Probes)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics