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clobuzarit
Also Known As:
ICI 55,897; ICI 55897; ICI-55897; clozic; Propanoic acid, 2-((4'-chloro(1,1'-biphenyl)-4-yl)methoxy)-2-methyl-
Networked:
8
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Phenyl Ethers: 8
Fibric Acids: 1474
Clofibric Acid: 75
Clofibrate: 861
clobuzarit: 8
Carboxylic Acids: 973
Acyclic Acids
Butyrates: 2613
Isobutyrates: 2
Fibric Acids: 1474
Clofibric Acid: 75
Clofibrate: 861
clobuzarit: 8
Ethers: 242
Phenyl Ethers: 8
Fibric Acids: 1474
Clofibric Acid: 75
Clofibrate: 861
clobuzarit: 8
Experts
1.
Whitehouse, Michael W
: 1 article (01/2005)
Related Diseases
1.
Rheumatoid Arthritis
04/01/1983 - "
A clinical and biochemical evaluation of Clozic, a novel disease modifying drug in rheumatoid arthritis.
"
04/01/1983 - "
We have compared two dose levels of Clozic, a novel agent with potential anti-rheumatoid activity, to D-penicillamine and aspirin in an observer blind randomised parallel group study of 56 patients with active rheumatoid arthritis.
"
02/01/1983 - "
We have discovered that 'Clozic' (ICI 55897), an agent with disease-modifying properties in rheumatoid arthritis patients, inhibits the growth of a variety of mammalian cell types including a matrix-secreting cell culture derived from neonatal rat hearts.
"
09/01/1981 - "
Clozic (ICI 55,897) in rheumatoid arthritis--a controlled comparison with gold.
"
01/01/1983 - "
Groups of 15 patients with active rheumatoid arthritis were treated for 24 weeks with zinc sulphate, trien, captopril, clozic in two doses or a combination of D-penicillamine and hydroxychloroquine.
"
2.
Atherosclerosis
08/31/1978 - "
The effect of ICI 55,897 and clofibrate on platelet function and other tests abnormal in atherosclerosis.
"
3.
Inflammation (Inflammations)
01/01/2005 - "
Drugs to treat inflammation are discussed under the following headings: (1) random discoveries covering copper, salicylates, heterocyclic diones, ACTH, adrenal steroids and disease-modifying agents (DMARDs); these include Au(I)-thiolates, chloroquine, and hydroxychloroquine, minocycline, cyclosporin, salazopyrine, D-penicillamine and methotrexate; (2) programmed NSAID developments covering salicylates and fenamates, arylalkanoates, diones, non-acidic NSAIDs, clozic, lobenzarit and coxibs; (3) synthetic glucocorticosteroids; and (4) 'Biologicals' for neutralising pro-inflammatory cytokines.
"
4.
Experimental Arthritis
05/01/1989 - "
APZ (150 mg kg-1 day-1) given for 10-13 days exhibited a reduction in joint pathology in established adjuvant arthritis in rats comparable with that of indomethacin (2 mg kg-1 day-1) and clobuzarit (20 mg kg-1 day-1).
"
5.
Arthritis (Polyarthritis)
05/01/1989 - "
Administration of the antiinflammatory and antirheumatic drugs (indomethacin, dexamethasone, and clobuzarit [CLOZIC]) during the course of the adjuvant-induced arthritis reduced the inflammatory response as judged by the measurement of oedema.
"
Related Drugs and Biologics
1.
Penicillamine (Cuprimine)
2.
Aspirin (Acetylsalicylic Acid)
3.
clobuzarit
4.
Indomethacin (Indometacin)
5.
Hydroxychloroquine (Plaquenil)
6.
Fenamates
7.
Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
8.
Antirheumatic Agents (DMARD)
9.
Cyclosporine (Ciclosporin)
10.
Cytokines