acifluorfen (Blazer)

protoporphyrinogen oxidase inhibitor

Also Known As:

Blazer; 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoate; 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrobenzoic acid; RH 6201; RH-6201; acifluorfen, calcium salt; acifluorfen, potassium salt; acifluorfen, sodium salt; scifluorfen

Networked: 19 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Nitrobenzoates: 3
        acifluorfen: 19
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Nitrobenzoates: 3
        acifluorfen: 19

Experts

1.	Mao, Zhiguo: 1 article (07/2021)
2.	Ong, Albert C M: 1 article (07/2021)
3.	Valluru, Manoj K: 1 article (07/2021)
4.	Avrenyeva, Ludmila I: 1 article (06/2021)
5.	Calina, Daniela: 1 article (06/2021)
6.	Docea, Anca Oana: 1 article (06/2021)
7.	Goumenou, Marina: 1 article (06/2021)
8.	Guseva, Galina V: 1 article (06/2021)
9.	Hernández, Antonio F: 1 article (06/2021)
10.	Kravchenko, Lidiya V: 1 article (06/2021)

Related Diseases

1.	Acute Erythroblastic Leukemia (Erythroleukemia) 10/04/1995 - "In the present study we show that long term maintenance of murine erythroleukemia (MEL) cells in acifluorfen, which is normally toxic to these cells at 5 microM concentration, results in cells that grow at a near normal rate in 100 microM acifluorfen. "
2.	Avitaminosis (Vitamin Deficiency) 06/01/2021 - "This study aimed to evaluate the long-term low-dose effects of exposure to a mixture of 6 pesticide active substances (diquat, imazamox, imazethapyr, tepraloxydin, bentazone, acifluorfen) and to elucidate if chronic vitamin deficiency can influence their toxicity. "
3.	Neoplasms (Cancer) 11/01/2022 - "Tumor Regression Grading 1 to 3, modified Tumor Regression Grading 1 to 3, and Blazer 0 and 1 defined good responders. " 01/01/2019 - "The median overall survival of responders was significantly higher (Blazer 0-1: 42.9 months versus Blazer 2: 20.1 months, P = .018; tumor regression grade 1-3: 42.9 months versus tumor regression grade 4-5: 25.1 months, P = .04). " 01/01/2019 - "Tumor response in the three classifications was associated with second-stage completion (tumor regression grade 1-3: OR = 4.01, 95% CI: 1.12-14.36, P = .033; modified tumor regression grade 1-3: OR = 3.8, 95% CI: 1.13-12.6, P = .03; Blazer 0-1: OR = 5.45, 95% CI: 1.66-17.85, P = .005). " 01/01/2019 - "The tumor regression grade, modified tumor regression grade, and Blazer grade were used to classify patients as responders (tumor regression grade and modified tumor regression grade 1-3, Blazer 0-1) or nonresponders (tumor regression grade and modified tumor regression grade 4-5, Blazer 2) after the first stage. " 01/01/2016 - "Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development."
4.	Necrosis 09/01/2015 - "We gathered demographic, analytical and morphological data of the cases, and also reviewed the hepatic resection samples to measure the pathological response to chemotherapy according to Blazer's criteria, and to define the predominant patterns of response (mucin pools, fibrosis or necrosis). " 10/01/2020 - "acifluorfen, bifenox or oxadiazon), which result in leaf necrosis, aclonifen causes a different phenotype that is described as bleaching. " 10/01/2014 - "Interestingly, the transgenic rice plants showed resistance to oxidative stress caused not only by the peroxidizing herbicide acifluorfen (AF) as indicated by a reduced formation of leaf necrosis, a lower conductivity, lower malondialdehyde and H2O2 contents as well as sustained Fv/Fm compared to WT plants, but also by norflurazon, paraquat, salt, and polyethylene glycol. "
5.	Hallucinations (Hallucination) 01/01/2010 - "Blazer, 1990), and the Positive and Negative Syndrome Scale delusion and hallucinations items (S. " 06/01/2012 - "They were assessed with the Dissociative Experiences Scale (DES-II; Carlson & Putnam, 1993), a questionnaire on trauma (TQ; Davidson, Hughes, & Blazer, 1990), and the Positive and Negative Syndrome Scale (PANSS; Kay, Opler, & Lindenmayer, 1988) delusions and hallucinations items. "

Related Drugs and Biologics

1.	Pesticides
2.	Diquat
3.	imazamox
4.	imazethapyr
5.	bentazone
6.	Herbicides
7.	Protoporphyrinogen Oxidase (Protox)
8.	Peroxisome Proliferator-Activated Receptors (PPAR)
9.	Butyric Acid (Butanoic Acid)
10.	Carbaryl (Sevin)

Related Therapies and Procedures

1.	Catheters
2.	Hepatectomy
3.	Drug Therapy (Chemotherapy)
4.	Cryosurgery
5.	Radiofrequency Ablation