amiprilose

immunopotentiator

Also Known As:

1,2-O-isopropylidene-3-O-3'-(N',N'-dimethylamino-N-propyl)-D-glucofuranose; 3-O-(3-(dimethylamino)propyl)-1,2-O-(1-methylethylidene)- alpha-D-glucofuranose; SM 1213; SM-1213; Therafectin; amiprilose hydrochloride; amprilose

Networked: 11 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Sugars: 11126
  - Monosaccharides: 889
    - Pentoses: 288
      - Ribose: 415
        amiprilose: 11

Experts

1.	Li, Rong: 1 article (10/2020)
2.	Liao, Xiwen: 1 article (10/2020)
3.	Liu, Jianwei: 1 article (10/2020)
4.	Lv, Peizhen: 1 article (10/2020)
5.	Zhu, Xianze: 1 article (10/2020)
6.	Box, J H: 1 article (02/2000)
7.	Carpenter, B A: 1 article (02/2000)
8.	Fife, R S: 1 article (02/2000)
9.	Lanser, M E: 1 article (02/2000)
10.	Trentham, D E: 1 article (02/2000)

Related Diseases

1.	Rheumatoid Arthritis 06/01/1990 - "The anti-proliferate and anti-inflammatory effects of amiprilose hydrochloride, combined with its lack of cytotoxicity, suggest that this compound may be useful in the treatment of rheumatoid arthritis, a chronic autoimmune proliferate and inflammatory disease of connective tissue." 01/01/1998 - "Flare during drug withdrawal as a method to support efficacy in rheumatoid arthritis: amiprilose hydrochloride as an example in a double blind, randomized study." 02/01/2000 - "Amiprilose hydrochloride for the treatment of rheumatoid arthritis." 09/15/1989 - "Amiprilose hydrochloride for rheumatoid arthritis." 09/15/1989 - "Amiprilose HCl has significant anti-inflammatory activity and a favorable safety profile when used as the sole antirheumatic therapy in patients with active rheumatoid arthritis. "
2.	Arthralgia (Joint Pain) 09/15/1989 - "The number of painful joints and swollen joints, joint pain and joint swelling indices, left and right grip strength, investigator global assessment, and patient global assessment returned to baseline for the amiprilose group and showed statistically significant (P less than 0.05) differences from the placebo group within 4 to 6 weeks. "
3.	Arthritis (Polyarthritis) 01/01/1989 - "In the LOU rats, the arthritis incidence was 7/46 (15%) in the amiprilose HC1 group vs 16/44 (36%) in the water group (p less than 0.01). " 08/01/1995 - "The regulatory effects of amiprilose HCl on cytokines support the potential of this drug as a therapeutic agent for the treatment of inflammatory arthritis." 08/01/1995 - "Amiprilose hydrochloride (amiprilose HCl) is a synthetic carbohydrate shown to have anti-inflammatory effects in animal models of inflammatory arthritis and in a multicenter clinical trial. "
4.	Thrombocytopenia (Thrombopenia) 09/15/1989 - "One patient on amiprilose developed thrombocytopenia of unknown cause; no other reported adverse effects were serious. "
5.	Synovitis 01/01/1989 - "Amiprilose HC1 (SM-1213), a nontoxic modified hexose sugar, was evaluated in in vivo and in vitro models of synovitis. " 01/01/1989 - "Evaluation of a modified hexose sugar, amiprilose hydrochloride, in experimental models of synovitis."

Related Drugs and Biologics

1.	Carbohydrates
2.	amiprilose
3.	Hexoses
4.	Sugars
5.	Sirolimus (Rapamycin)
6.	Cladribine
7.	Tacrolimus (Prograf)
8.	Cytokines
9.	Quipazine
10.	Pizotyline (BC 105)

Related Therapies and Procedures

1.	Therapeutics