C 76 (C76)

synthetic analog of cord factor; induced complete remission of transplants of syngenic murine fibrosarcoma

Also Known As:

C76; C-76; 6,6'-di-O-tetradecyl-3-hydroxyoctadecanoyl-alpha,alpha trehalose; 6,6'-bis((2R,3R)-3-hydroxy-2-tetradecyloctadecanoate)-trehalose

Networked: 21 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cai, Jiachang: 1 article (01/2021)
2.	Chen, Jiawei: 1 article (01/2021)
3.	Zeng, Yu: 1 article (01/2021)
4.	Zhang, Rong: 1 article (01/2021)
5.	Bijelic, Lana: 1 article (08/2020)
6.	Cannon, Timothy: 1 article (08/2020)
7.	Darcy, Kathleen: 1 article (08/2020)
8.	Stodghill, Joshua: 1 article (08/2020)
9.	Tian, Chunqiao: 1 article (08/2020)
10.	Abbott, J Dawn: 1 article (01/2019)

Related Diseases

1.	Fibrosarcoma 11/01/1979 - "Intratumoral injection of ultrasonically prepared emulsions of the synthetic glycolipid methly 6-O-(2-tetradecyl-3-hydroxyoctadecanoyl)-alpha-D-glucopyranoside (designated C39) induced complete regression of transplants of a syngeneic murine fibrosarcoma in most of the treated animals as did 6,6'-di-O(2-tetradecyl-3-hydroxyoctadecanoyl)-alpha,alpha,-trehalose (designated C76) in a previous study. " 11/15/1978 - "Injection of emulsified 6,6'-di-O-2-tetradecyl-3-hydroxyoctadecanoyl-a, a trehalose designated C76, a synthetic analogue of the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM), into transplants of an established, syngeneic murine fibrosarcoma induced complete regression of tumor in a number of animals. "
2.	Human Influenza (Influenza) 01/01/2023 - "Therefore, the goal of this work was to study the effect of two batches of a mixture of polyhydrated fullerenes with a mass ratio of 78.1% C60/C70 and 21.9% C76/C78/C84 on the influenza A (H1N1) virus. "
3.	Infections 06/01/1993 - "Over all, the dynamics of antibody responses were very similar for infections with the five different isolates, although a significant delay in positive and maximum antibody titres was seen in the group infected with C-76, the isolate exhibiting a marked low infectivity to domestic mammals. " 09/01/1992 - "Antibody response against C-76 infection was significantly delayed and lower than against GM-1. " 04/01/1978 - "The synthetic C76 trehalose diesters, which are capable of enhancing nonspecific resistance to infection, increase the immune response in mice, even when injected in metabolizable oil. " 06/01/1993 - "For infections with the C-76 isolate, positive titres appeared between days 16 and 20 p.i. with the CSLE antigen and, on day 27 p.i. with the ES and CTAB antigens. "
4.	Fibrosis (Cirrhosis) 11/01/2006 - "Adrenal dysfunction was frequent in patients with advanced cirrhosis (Child C: 76% vs. Child B: 25%, P = .08). " 01/01/2018 - "Five hundred and fifty-one patients with advanced fibrosis (n = 158) or cirrhosis (CPS-A:317,CPS-B/C:76) and SVR after interferon and ribavirin-free DAA therapy treated between October 2013 and April 2016 were studied with a median follow-up of 65.6 (13.0-155.3) weeks. " 12/01/2018 - "Pharmacological inhibition of HIF-2α by the HIF-2α translation inhibitor C76 (compound 76) reduced right ventricular systolic pressure and right ventricular hypertrophy and inhibited RHF and fibrosis as well as obliterative pulmonary vascular remodeling in Egln1Tie2Cre mice and Sugen 5416/hypoxia PAH rats. "
5.	Neoplasms (Cancer) 01/01/2023 - "Behind the overall differences between the two data sources, we identified that the vast majority were due to ill-defined ICD codes: malignant neoplasm of other and ill-defined sites (C76), and malignant neoplasm without specification of site (C80). " 11/15/1978 - "Injection of emulsified 6,6'-di-O-2-tetradecyl-3-hydroxyoctadecanoyl-a, a trehalose designated C76, a synthetic analogue of the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM), into transplants of an established, syngeneic murine fibrosarcoma induced complete regression of tumor in a number of animals. "

Related Drugs and Biologics

1.	Fullerenes
2.	Glycolipids
3.	Emulsions
4.	C 39 (C39)
5.	Trehalose
6.	Soot
7.	Monocrotaline
8.	Carbapenems (Carbapenem Antibiotics)
9.	Sulfonamides
10.	Ribavirin (Virazole)

Related Therapies and Procedures

1.	Vena Cava Filters (Inferior Vena Cava Filter)
2.	Intralesional Injections
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)