cobaltous chloride (cobalt(II)chloride)

RN given refers to unlabeled cpd; RN in Chemline for cobalt trichloride: 10241-04-0; RN for 60-labeled cpd: 14543-09-0; RN for 57-labeled cpd: 164113-89-1; RN for 58-labeled cpd: 29377-09-1; structure

Also Known As:

Networked: 712 relevant articles (6 outcomes, 95 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Feng, Jianqiang: 7 articles (07/2013 - 01/2011)
2.	Bansal, Anju: 6 articles (11/2012 - 01/2008)
3.	Lan, Aiping: 5 articles (07/2013 - 01/2011)
4.	Rosenberger, Christian: 4 articles (04/2015 - 07/2002)
5.	Nangaku, Masaomi: 4 articles (04/2015 - 11/2011)
6.	Caltana, Laura: 4 articles (12/2014 - 07/2007)
7.	Brusco, Alicia: 4 articles (12/2014 - 07/2007)
8.	Hu, Fen: 4 articles (07/2013 - 01/2011)
9.	Shukla, Dhananjay: 4 articles (11/2012 - 02/2008)
10.	Zhou, Wei: 4 articles (11/2012 - 02/2008)

Related Diseases

1.	Anoxia (Hypoxia) 08/01/2013 - "Cobalt Chloride-induced Hypoxia Ameliorates NLRP3-Mediated Caspase-1 Activation in Mixed Glial Cultures." 03/19/2015 - "This study is aimed at investigating the molecular pathways associated with the hypoxic condition in human fetal striatal neuroblasts (human striatal precursor (HSP) cells), using the hypoxia-mimetic agent cobalt chloride (CoCl2). " 02/01/2015 - "Therefore, in the present study, mouse peritoneal macrophages and splenocytes were subjected to hypoxia exposure (0.5 % O2) and hypoxia mimetic Cobalt chloride (CoCl2) treatment to evaluate their effect on immune response and delineate the underlying signaling mechanisms. " 01/01/2015 - "In this study, we investigated the cellular mechanisms regulating the autophagy gene Ambra1, after exposure to a hypoxia mimetic, cobalt chloride (CoCl2). " 01/01/2015 - "In this study, we investigated whether mimicking hypoxia using cobalt chloride (CoCl2) could maintain human periodontal ligament (HPDL) cell stemness. "
2.	Hemorrhage 09/01/2001 - "Neuronal activity in the vlPAG was inhibited with either lidocaine or cobalt chloride 5 min before hemorrhage (2.5 ml/100 g body wt) was initiated in conscious, unrestrained rats. " 04/01/1983 - "VCN administration to rats treated with cobalt chloride or SKF 525A (cytochrome P-450 enzymes inhibitors) resulted in a significant protection against GI bleeding (10 and 40%, respectively). " 07/01/2002 - "High-amplification immunohistochemical analyses were used to study the expression of HIF-1alpha and -2alpha in kidneys of rats exposed to systemic hypoxia bleeding anemia, functional anemia (0.1% carbon monoxide), renal ischemia, or cobaltous chloride (which is known to mimic hypoxia). " 05/01/2004 - "To investigate regional aspects of hypoxic regulation of adrenomedullin (AM) in kidneys, we mapped the distribution of AM in the rat kidney after hypoxia (normobaric hypoxic hypoxia, carbon monoxide, and CoCl(2) for 6 h), anemia (hematocrit lowered by bleeding) and after global transient ischemia for 1 h (unilateral renal artery occlusion and reperfusion for 6 and 24 h) and segmental infarct (6 and 24 h). "
3.	Cleft Palate (Palate, Cleft) 10/01/1967 - "Inhibition of cortisone-induced cleft palate in mice by cobaltous chloride." 03/01/1978 - "Various cobalt-containing agents (cyanocobalamin, sodium cobaltinitrite, and cobaltous chloride), which formerly had been shown to prevent the onset of cleft palate in CF-1 mice injected with cortisone, were studied to determine whether they would afford similar protection against phenytoin. "
4.	Neoplasms (Cancer) 04/01/2010 - "The results indicate that the present model is well suited for studies on cancer cell invasion in the matrix and that the addition of CoCl(2) on day 3 of the experiment is indicated because it markedly increases the invasion and improves the model." 01/01/2013 - "The growth rate of tumor cells in the CoCl(2) + glibenclamide group was lower than that seen in the other groups. " 02/01/2012 - "Metastatic rat and human tumor lines upregulate C4.4A expression when cultured in the presence of CoCl(2). " 11/01/2010 - "Our results show stabilization of HIF-1alpha in LMM3 cells under CoCl(2) and functional changes associated with enhanced cell survival and growth but not with tumor dissemination." 01/01/2015 - "In this study, we show that Autophagy can mediate programmed cell death (PCD) of cancer cells in responding to cobalt chloride (CoCl2)-induced hypoxia in a Beclin-1-independent but autophagy protein 5 (ATG5)-dependent manner. "
5.	Prostatic Neoplasms (Prostate Cancer) 07/01/2007 - "In this study, we observed the alteration of cell adhesion after CoCl(2) treatment and analysed the potential mechanisms responsible for such adaptations in a prostate cancer cell line PC-3 M cell. " 10/01/2002 - "In the present study, we have explored further the linkage between mTOR and HIF-1 in PC-3 prostate cancer cells treated with hypoxia or the hypoxia mimetic agent, CoCl(2). " 03/15/2013 - "A biodistribution and toxicity study of cobalt dichloride-N-acetyl cysteine in an implantable MRI marker for prostate cancer treatment." 01/01/1999 - "We examined the relationship between COX-2 expression and VEGF induction in response to cobalt chloride (CoCl2)-simulated hypoxia in three human prostate cancer cell lines with differing biological phenotypes. " 01/01/1999 - "Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line."

Related Drugs and Biologics

1.	Cytochrome P-450 Enzyme System (Cytochrome P450)
2.	Cobalt
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Enzymes
5.	rhodioloside
6.	peoniflorin
7.	Cortisone
8.	hexanitritocobaltate(III) (sodium cobaltinitrite)
9.	Vitamin B 12 (Cyanocobalamin)
10.	Phenytoin (Dilantin)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Deep Hypothermia Induced Circulatory Arrest
3.	Renal Dialysis (Hemodialysis)
4.	Electrodes (Electrode)
5.	Injections