progabide (Gabrene)

03/01/1990 - "Although progabide was less effective in the dorsal HIPP kindled seizures, the efficacy was potent in AM, FC and ventral HIPP kindled seizures. "
06/01/1987 - "A controlled study of progabide in partial seizures: methodology and results."
01/01/1997 - "The only effect seen in 25-day-old animals was prolongation of the latency of major seizures after the highest dose of progabide."
01/01/1995 - "Gabrene (25, 50, 100 and 250 mg/kg i.p.) inhibited PTZ-kindled seizures. "
01/01/1988 - "Preliminary observations on the activity of progabide, administered as monotherapy in complex partial seizures."

10/01/1984 - "A significant reduction of the total seizure number was observed in the progabide period as compared with the placebo period, both in the whole patient group (p less than 0.01) and in the two subgroups of patients with generalized (p less than 0.01) and partial (p less than 0.05) epilepsies.(ABSTRACT TRUNCATED AT 250 WORDS)"
01/01/1984 - "Progabide has been shown to be effective in various forms of epilepsy in double-blind and long-term clinical trials. "
10/01/1984 - "Progabide treatment in severe epilepsy: a double-blind cross-over trial versus placebo."
12/01/1983 - "Double-blind crossover trial of progabide versus placebo in severe epilepsies."
01/01/1987 - "Long-term treatment of epilepsy: open multicenter trial with progabide in epileptic patients."

06/01/1987 - "No change was observed during this trial in the severity of dyskinesia on progabide treatment but the drug significantly extended the "on" period as compared with placebo. "
01/01/1985 - "The possible mechanism of action of progabide in dyskinesia is discussed in the light of its pharmacological properties. "
01/01/1985 - "At variance with studies in tardive dyskinesia progabide was not effective in this kind of dyskinesia but an increase in the "on" time has been observed in both studies. "
01/01/1985 - "These results suggest that progabide can be useful in the treatment of neuroleptic-induced dyskinesia."
06/01/1987 - "In the second trial, 20 patients with neuroleptic-induced dyskinesia (TD) entered an open dose ranging trial with progabide. "

02/01/1986 - "Progabide for refractory partial epilepsy: a controlled add-on trial."
04/01/1983 - "Progabide: a controlled trial in partial epilepsy."
06/29/1984 - "Progabide appears to be as effective as primary antiepileptic drug for adjunctive therapy in partial epilepsy refractory to previous high-dose therapy. "
02/01/1986 - "Progabide, an experimental GABA-ergic antiepileptic drug, was given in a placebo-controlled double-blind cross-over trial to 19 adult patients with chronic partial epilepsy refractory to previous high-dose antiepileptic drug therapy. "
01/01/1987 - "A long-term open multicenter trial was carried out in 15 European centers with therapy-resistant epileptics to evaluate the efficacy and safety of progabide, a new antiepileptic GABA receptor agonist; 187 patients, suffering from partial epilepsy (57%), primary generalized epilepsy (20%), secondary generalized epilepsy (21%), and unclassified generalized epilepsy (2%), participated in the study. "

02/25/1992 - "These data would suggest that progabide and perhaps other GABAmimetic compounds can prevent the development of tardive dyskinesia in man."
01/01/1985 - "At variance with studies in tardive dyskinesia progabide was not effective in this kind of dyskinesia but an increase in the "on" time has been observed in both studies. "
01/01/1985 - "These studies are parallel to and support the clinical observations that dyskinetic movements following a direct action at the dopamine receptor (tardive dyskinesia) may be reversed by progabide whereas those associated with dopamine neuron activity, perhaps together with noradrenergic activation (L-dopa dyskinesia), are resistant to the antidyskinetic action of progabide."
04/13/2011 - "To determine the clinical effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP) for people with schizophrenia or other chronic mental illnesses who also developed neuroleptic-induced tardive dyskinesia. "
10/18/2004 - "To determine the effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP)) for people with antipsychotic-induced tardive dyskinesia (TD) and schizophrenia or other chronic mental illnesses. "