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progabide acid

RN given refers to NA salt; structure

Also Known As:

SL 75102; SL-75102; Butanoic acid, 4-(((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene)amino)-, monosodium salt

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Butyrates: 2613
      - Aminobutyrates: 1253
        gamma-Aminobutyric Acid: 8890
        progabide acid: 2
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Aminobutyrates: 1253
    - gamma-Aminobutyric Acid: 8890
      - progabide acid: 2

Related Diseases

1.

Seizures (Absence Seizure)

03/01/1982 - "Both progabide and SL 75102 exhibit a broad spectrum of anticonvulsant activities against seizures which involve GABA-mediated events (bicuculline, picrotoxinin and pentylenetetrazol) or which are apparently independent of GABAergic mechanisms (penicillin, strychnine, electroshock and audiogenic seizures). "
04/01/1985 - "A variety of drugs that specifically manipulate inhibitory or excitatory neurotransmitter systems proved capable of dose dependently blocking these seizures, i.e., the anticholinergic drug biperiden (ED50 12 mg/kg i.p.), the excitatory amino acid antagonist (+/-)-2-amino-7-phosphonoheptanoic acid (120 mg/kg), the gamma-aminobutyric acid (GABA) agonists muscimol (0.66 mg/kg), 4,5,6,7-tetrahydroisoxazolo(5,4-c) pyridine-3-ol (1.3 mg/kg), progabide (50 mg/kg) and its acidic metabolite SL 75102 (45 mg/kg), the GABA aminotransferase inhibitors aminooxyacetic acid (0.9 mg/kg), gamma-acetylenic GABA (2.1 mg/kg) and ethanolamine-O-sulfate (1000 mg/kg), the GABA uptake inhibitor (-)-nipecotic acid ethyl ester (21 mg/kg), the dopamine agonist apomorphine (approximately 5 mg/kg), the dopamine precursor 3,4-dihydroxy-L-phenylalanine (34 mg/kg), and the alpha-adrenoceptor agonists clonidine (0.38 mg/kg) and xylazine (approximately 10 mg/kg). "

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	progabide (Gabrene)
3.	GABA Uptake Inhibitors
4.	GABA Agonists (GABA Receptor Agonists)
5.	Excitatory Amino Acid Antagonists
6.	Cholinergic Antagonists (Anticholinergics)
7.	Dopamine Agonists (Dopamine Agonist)
8.	Neurotransmitter Agents (Neurotransmitter)
9.	Xylazine (Xylazin)
10.	Strychnine