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histidine-rich proteins

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Also Known As:

HRG protein, human; Hrg protein, mouse; Hrg protein, rat; histidine-proline-rich glycoprotein; histidine-proline-rich glycoprotein, human; histidine-rich alpha2 glycoprotein, mouse; histidine-rich glycoprotein; histidine-rich glycoprotein, human; histidine-rich glycoprotein, mouse; histidine-rich glycoprotein, rat; histidine-rich glycoproteins; HRG

Networked: 277 relevant articles (6 outcomes, 43 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - histidine-rich proteins: 277

Experts

1.	Lupu, Ruth: 11 articles (11/2015 - 08/2002)
2.	Olsson, Anna-Karin: 9 articles (10/2013 - 01/2004)
3.	Kumar, R: 7 articles (03/2008 - 01/2000)
4.	Menendez, Javier A: 6 articles (11/2015 - 01/2005)
5.	Claesson-Welsh, Lena: 6 articles (10/2015 - 01/2004)
6.	Hamburger, Anne W: 6 articles (11/2014 - 06/2008)
7.	Mehmi, Inderjit: 6 articles (08/2006 - 01/2003)
8.	Kumar, Rakesh: 6 articles (04/2005 - 02/2002)
9.	Jahnen-Dechent, Willi: 5 articles (04/2015 - 08/2008)
10.	Yumoto, Noriko: 5 articles (01/2009 - 01/2007)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "The aim of this study was to determine the chronology of this alteration along the progression of HRG to GC, to test the hypothesis that it occurs early in the chronology of this pathway and plays a mechanistic role in the long-term cancer risk. " 02/01/2009 - "To investigate the potential transactivation of HER-2, in 171 breast cancers from the GENICA study with negative/low expression of HER-2 we analyzed the expression of pHER-2, HRG, HER-3 and HER-4 by immunohistochemistry. " 07/01/2006 - "The major goal of the present study was to determine whether endogenous HRG causes autocrine/paracrine activation of ErbB-2/ErbB-3 and contributes to the proliferation of mammary epithelial tumor cells. " 01/15/2004 - "In this study, we show that recombinant human histidine-rich glycoprotein (HRGP) has potent antiangiogenic properties as judged from effects on a syngeneic tumor model in C57/bl6 mice. " 05/29/2003 - "Transfection of the deletion mutant of HRG described in this study (HRG/M) into MCF-7 cells resulted in the dissociation of the tumor-promoting activity of HRG from the sensitization to Doxo, that is, although the cells did not become more aggressive or E2-independent they became more sensitive to Doxo. "
2.	Prostatic Neoplasms (Prostate Cancer) 08/15/2010 - "In the present study, we tested the efficacy of VMY-1-103 in inhibiting HRG-induced cell proliferation in LNCaP prostate cancer cells. " 06/01/2001 - "Together these results suggest that p85-sErbB3 is a naturally occurring negative regulator of HRG-stimulated signal transduction that may have important therapeutic applications in human malignancies associated with HRG-mediated cell growth such as breast and prostate cancer." 08/15/2010 - "Our previous studies demonstrated that transgenic expression of activated ErbB-2 in the mouse prostate initiated PCa and either the overexpression of ErbB-2 or the addition of the ErbB-2/ErbB-3 ligand, heregulin (HRG), induced cell cycle progression in the androgen-responsive prostate cancer cell line, LNCaP. " 01/01/2006 - "In order to elucidate the mechanisms underlying the ISL regulation of prostate cancer cell proliferation, the present study attempted to determine whether ISL inhibits heregulin (HRG)-beta-induced ErbB3 signaling. " 10/01/2008 - "Our data support a role for EBP1 in the development of hormone-refractory prostate cancer via inhibition of both AR- and HRG-stimulated growth and present a novel strategy for treating androgen-refractory prostate cancer."
3.	Pre-Eclampsia (Preeclampsia) 12/01/2012 - "The aim of this study was to investigate whether the combination of HRG and uterine artery Doppler ultrasonography can be used as a predictor of preeclampsia. " 12/01/2012 - "The combination of HRG and uterine artery Doppler may predict preterm preeclampsia in early pregnancy." 12/01/2012 - "The combination of HRG and PI revealed a sensitivity of 91% and a specificity of 62% for preterm preeclampsia. " 12/01/2012 - "HRG levels were significantly lower in women who developed preterm preeclampsia compared with controls, but not for women developing preeclampsia in general. " 12/01/2012 - "Significantly lower levels of HRG have been demonstrated as early as in the first trimester in women later developing preeclampsia compared with normal pregnancies. "
4.	Sepsis (Septicemia) 09/30/2010 - "Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis." 06/01/2015 - "Furthermore, potent FXR agonists might be beneficial in serious health conditions where HRG is reduced, for example, in hepatocellular carcinoma but also other solid cancers, liver failure, sepsis and pre-eclampsia. "
5.	Hepatocellular Carcinoma (Hepatoma) 10/06/2015 - "Histidine-rich glycoprotein function in hepatocellular carcinoma depends on its N-glycosylation status, and it regulates cell proliferation by inhibiting Erk1/2 phosphorylation." 06/01/2015 - "We show that HRG is a novel transcriptional target gene of FXR in human hepatoma cells, human upcyte® primary hepatocytes and 3D human liver microtissues in vitro and in mouse liver in vivo. " 10/06/2015 - "HRG overexpression in Huh7 and MHCC-97H hepatoma cell lines led to decreased cell proliferation, colony-forming ability, and tumor growth, and increased cell apoptosis. " 06/01/2015 - "Furthermore, potent FXR agonists might be beneficial in serious health conditions where HRG is reduced, for example, in hepatocellular carcinoma but also other solid cancers, liver failure, sepsis and pre-eclampsia. "

Related Drugs and Biologics

1.	histidine-rich proteins
2.	Antigen-Antibody Complex (Immune Complex)
3.	glucuronyl glucosamine glycan sulfate (Vessel)
4.	Ciprofloxacin (Cipro)
5.	pertuzumab
6.	Neuregulin-1 (Neuregulin 1)
7.	RNA (Ribonucleic Acid)
8.	Epidermal Growth Factor (EGF)
9.	Messenger RNA (mRNA)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Condoms (Condom)
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)