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zinc protoporphyrin

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Also Known As:

ZnPP-IX; ZnPP9; zinc protoporphyrin IX; zinc-protoporphyrin-9; (SP-4-2)-dihydrogen (7,12-diethenyl-3,8,13,17- tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N(21),N(22),N(23),N(24))zincate(2-)

Networked: 224 relevant articles (12 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fang, Jun: 6 articles (11/2015 - 07/2003)
2.	Maeda, Hiroshi: 5 articles (11/2015 - 07/2003)
3.	Benevides, Norma Maria Barros: 4 articles (12/2015 - 12/2011)
4.	Bezerra, Mirna Marques: 4 articles (12/2015 - 12/2011)
5.	Chaves, Hellíada Vasconcelos: 4 articles (12/2015 - 12/2011)
6.	de Araújo, Ianna Wivianne Fernandes: 3 articles (12/2015 - 12/2011)
7.	Rodrigues, José Ariévilo Gurgel: 3 articles (12/2015 - 12/2011)
8.	Ribeiro, Natássia Albuquerque: 3 articles (12/2015 - 07/2014)
9.	Nakamura, Hideaki: 3 articles (11/2015 - 02/2013)
10.	Wang, Shuai: 3 articles (03/2015 - 06/2013)

Related Diseases

1.	Ischemia 02/01/2015 - "Whereas, treatment with zinc protoporphyrin IX (a HO-1 inhibitor) into the IPC+ischemia-operated groups did not preserve the IPC-mediated increase of HO-1 and lost beneficial effects of IPC by inhibiting ischemia-induced DNA damage and lipid peroxidation. " 05/01/2014 - "Anesthetized male rats were pretreated with ISO [intraperitoneal (i.p.) injection of 10 mg/kg] prior to ischemia in the absence and/or presence of zinc protoporphyrin IX (ZnPPIX, i.p., 10 mg/kg), which is an inhibitor of HO-1, and then subjected to ischemia for 30 min followed by reperfusion for 24 h. " 01/01/2014 - "For specific experiments, zinc protoporphyrin (ZnPP, 20 mg/kg), an HO-1 inhibitor, was intraperitoneally administered at 24 h prior to ischemia. " 08/01/2012 - "Rats were pretreated with zinc protoporphyrin (ZnPP, 10mg/kg, i.p.), a HO-1 inhibitor, at 16 and 3hr prior to ischemia. " 06/01/2004 - "Then hind limb ischemia was made on other 12 rats through clamping the infrarenal aorta for 2 hours with a microvascular clip, among whom, 6 rats were given zinc protoporphyrin (ZnPP), an inhibitor of HO. "
2.	Lung Injury 06/01/2015 - "Moreover, the HO-1 inhibitor zinc protoporphyrin IX significantly eliminated the protective effect of H2 on septic lung injury. " 06/01/2013 - "Further, these beneficial effects of MF on the septic lung injury were eliminated by ZnPP IX, a specific HO-1 inhibitor. " 04/01/2002 - "Zinc protoporphyrin (ZnPP), an inhibitor of HO, was used to determine whether HO-1 was induced by Hb after lung injury. " 06/25/2002 - "To investigate the role of endogenous heme oxygenase (HO)/carbon monoxide (CO) system in the lung injury as assessed by lung histology, polymorphonuclear count, malondialdehyde content and wet-to-dry weight ratio following ischemia-reperfusion (I/R) of hind limbs, zinc protoporphyrin (ZnPP), an inhibitor of HO activity, was used, and the lung HO activity and blood carboxyhemoglobin (COHb) level were measured. "
3.	Infection 02/28/2003 - "The increase in both blood flow and capillary density was significantly greater in the ischemic hindlimbs that had been injected with ad-HO-1 than in those injected with ad-wt. These angiogenic effects of ad-HO-1 infection could be completely abolished by treating the animals with the HO inhibitor, zinc protoporphyrin, indicating that they were specifically due to the expression of HO-1. " 07/01/2000 - "Erythrocyte protoporphyrin and zinc protoporphyrin concentrations were studied in 50 patients with chronic hepatitis C infection and various degrees of liver damage. " 01/01/2013 - "gondii infection, BALB/c and C57BL/6 mice were infected with the ME49 strain and treated with zinc protoporphyrin IX (ZnPPIX) or hemin, which inhibit or induce HO-1 activity, respectively. " 01/01/2010 - "Cobalt protoporphyrin IX (CoPP, an HO-1 inducer), infection with a recombinant adenovirus carried with HO-1 gene (Adv-HO-1), or zinc protoporphyrin (ZnPP, an HO-1 inhibitor) was used to stimulate HO-1 induction or inhibit HO-1 activity. " 03/15/2009 - "Infection-associated apoptosis was also markedly increased in polyethylene glycol-conjugated zinc-protoporphyrin IX-treated mouse liver cells and cultured macrophages. "
4.	Erythropoietic Protoporphyria 10/01/1983 - "In vivo albumin is present in the plasma and the results may help to explain why patients with erythropoietic protoporphyria (erythrocytes containing free protoporphyrin) are photosensitive, whereas patients with lead intoxication and iron deficiency (erythrocytes containing zinc protoporphyrin) are not." 12/01/2015 - "Laboratory diagnosis of erythropoietic protoporphyria (EPP) requires a marked increase in total erythrocyte protoporphyrin (300-5000 μg/dL erythrocytes, reference interval <80 μg/dL) and a predominance (85%-100%) of metal-free protoporphyrin [normal, mostly zinc protoporphyrin (reference intervals for the zinc protoporphyrin proportion have not been established)]; plasma porphyrins are not always increased. " 05/01/1998 - "Protoporphyrin and zinc-protoporphyrin were measured in the erythrocytes of normal subjects, workers exposed to lead and patients with iron deficiency and erythropoietic protoporphyria (EPP). " 02/21/1989 - "In erythropoietic protoporphyria and lead poisoning, free protoporphyrin (PPIX) and zinc protoporphyrin (ZPP), respectively, accumulate in erythrocytes. "
5.	Sepsis (Septicemia) 01/01/2013 - "Further, the protective effects of PD on sepsis were abrogated by ZnPP IX, a specific HO-1 inhibitor. " 03/01/2001 - "This protective effect was reversed by ZnPP-IX. These results show an important protective role for the HO pathway against sepsis-induced diaphragmatic dysfunction, which could be related to its antioxidant properties." 06/01/2011 - "However, the combination of pretreatment plus posttreatment with ZnPP IX enhances sepsis severity because of an increase in circulating levels of heme, which is deleterious to the host tissues and also inhibits neutrophil migration." 07/01/2015 - "Male Institute for Cancer Research mice were randomized into 6 groups: sham; sham + H2; severe sepsis; severe sepsis + H2; severe sepsis + zinc protoporphyrin IX (ZnPPIX), a heme oxygenase-1 (HO-1) inhibitor; and severe sepsis + H2 + ZnPPIX. "

Related Drugs and Biologics

1.	Iron
2.	Carbon Monoxide
3.	Heme Oxygenase (Decyclizing) (Heme Oxygenase)
4.	Heme Oxygenase-1
5.	Hemin (Panhematin)
6.	Zinc
7.	Gliotoxin
8.	Doxorubicin (Adriamycin)
9.	zinc protoporphyrin
10.	Ferritins (Ferritin)

Related Therapies and Procedures

1.	Length of Stay
2.	Ligation
3.	Intravenous Injections
4.	Intraperitoneal Injections
5.	Renal Dialysis (Hemodialysis)