zinc protoporphyrin

Also Known As:

ZnPP-IX; ZnPP9; zinc protoporphyrin IX; zinc-protoporphyrin-9; (SP-4-2)-dihydrogen (7,12-diethenyl-3,8,13,17- tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N(21),N(22),N(23),N(24))zincate(2-)

Networked: 345 relevant articles (16 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fang, Jun: 11 articles (05/2021 - 07/2003)
2.	Maeda, Hiroshi: 9 articles (05/2021 - 07/2003)
3.	Chen, Jun-Liang: 5 articles (02/2020 - 06/2017)
4.	Pang, Qing-Feng: 5 articles (02/2020 - 06/2017)
5.	Nakamura, Hideaki: 5 articles (01/2020 - 02/2013)
6.	Lozoff, Betsy: 4 articles (01/2021 - 08/2010)
7.	Tsukigawa, Kenji: 4 articles (04/2016 - 02/2013)
8.	Benevides, Norma Maria Barros: 4 articles (12/2015 - 12/2011)
9.	Bezerra, Mirna Marques: 4 articles (12/2015 - 12/2011)
10.	Chaves, Hellíada Vasconcelos: 4 articles (12/2015 - 12/2011)

Related Diseases

1.	Lung Injury 06/01/2015 - "Moreover, the HO-1 inhibitor zinc protoporphyrin IX significantly eliminated the protective effect of H2 on septic lung injury. " 06/01/2013 - "Further, these beneficial effects of MF on the septic lung injury were eliminated by ZnPP IX, a specific HO-1 inhibitor. " 04/01/2002 - "Zinc protoporphyrin (ZnPP), an inhibitor of HO, was used to determine whether HO-1 was induced by Hb after lung injury. " 04/01/2016 - "However, the protective effects of AS on sepsis-induced lung injury were eliminated by ZnPP IX, an HO-1 competitive inhibitor. " 09/01/2019 - "The role of HO-1 on seawater-drowning pulmonary injury was explored via HO-1 activity inhibitors (Zinc protoporphyrin) in vitro and in vivo. "
2.	Sepsis (Septicemia) 01/01/2013 - "Further, the protective effects of PD on sepsis were abrogated by ZnPP IX, a specific HO-1 inhibitor. " 04/01/2016 - "However, the protective effects of AS on sepsis-induced lung injury were eliminated by ZnPP IX, an HO-1 competitive inhibitor. " 01/01/2020 - "In myocardial tissues with severe sepsis, H2 gas treatment reduced mitochondrial dysfunction, whereas zinc protoporphyrin (ZnPPIX) negated these beneficial effects. " 06/01/2011 - "However, the combination of pretreatment plus posttreatment with ZnPP IX enhances sepsis severity because of an increase in circulating levels of heme, which is deleterious to the host tissues and also inhibits neutrophil migration." 03/01/2001 - "This protective effect was reversed by ZnPP-IX. These results show an important protective role for the HO pathway against sepsis-induced diaphragmatic dysfunction, which could be related to its antioxidant properties."
3.	Iron Deficiencies 08/01/2013 - "The aim of this study was to assess the prevalence of subclinical iron deficiency in whole blood donors with Hb levels above cutoff levels for donation by measuring zinc protoporphyrin (ZPP) levels. " 01/01/2020 - "Screening for iron deficiency in surgical patients based on noninvasive zinc protoporphyrin measurements." 01/01/2017 - "Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan preschool children: a community-based survey." 02/17/2016 - "Non-invasive detection of iron deficiency by fluorescence measurement of erythrocyte zinc protoporphyrin in the lip." 01/01/2015 - "[A neonate with anaemia of prematurity: zinc protoporphyrin identifies iron deficiency anaemia without iron deficiency]."
4.	Ischemia 02/01/2015 - "Whereas, treatment with zinc protoporphyrin IX (a HO-1 inhibitor) into the IPC+ischemia-operated groups did not preserve the IPC-mediated increase of HO-1 and lost beneficial effects of IPC by inhibiting ischemia-induced DNA damage and lipid peroxidation. " 05/01/2014 - "Anesthetized male rats were pretreated with ISO [intraperitoneal (i.p.) injection of 10 mg/kg] prior to ischemia in the absence and/or presence of zinc protoporphyrin IX (ZnPPIX, i.p., 10 mg/kg), which is an inhibitor of HO-1, and then subjected to ischemia for 30 min followed by reperfusion for 24 h. " 01/01/2014 - "For specific experiments, zinc protoporphyrin (ZnPP, 20 mg/kg), an HO-1 inhibitor, was intraperitoneally administered at 24 h prior to ischemia. " 08/01/2012 - "Rats were pretreated with zinc protoporphyrin (ZnPP, 10mg/kg, i.p.), a HO-1 inhibitor, at 16 and 3hr prior to ischemia. " 06/01/2004 - "Then hind limb ischemia was made on other 12 rats through clamping the infrarenal aorta for 2 hours with a microvascular clip, among whom, 6 rats were given zinc protoporphyrin (ZnPP), an inhibitor of HO. "
5.	Septic Shock (Toxic Shock Syndrome) 03/01/2002 - "IL-10-mediated protection against LPS-induced septic shock in mice was significantly attenuated by cotreatment with the HO inhibitor, zinc protoporphyrin. " 06/01/2009 - "Eighty healthy and clean Sprague-Dawley rats were randomly divided into 4 groups: control group (group C) , septic shock group (group SS) , lipopolysaccharide plus ZnPP-IX group (group LZ) , and ZnPP-IX (group Z) . " 06/01/2000 - "The changes of CO levels and the effects of zinc protoporphyrin IX (ZnPP), an inhibitor of heme-oxygenase (HO), in endotoxin shock and the efficacy of hemin, an inducer of HO were investigated. "

Related Drugs and Biologics

1.	Heme Oxygenase-1
2.	protoporphyrin IX
3.	Zinc
4.	Heme Oxygenase (Decyclizing) (Heme Oxygenase)
5.	C-Reactive Protein
6.	Hemoglobins (Hemoglobin)
7.	Hemin (Panhematin)
8.	Cholesterol
9.	Superoxide Dismutase
10.	Sulfonic Acids

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Renal Dialysis (Hemodialysis)
4.	Length of Stay
5.	Ligation