pardaxin

08/01/2012 - "Overall, these results indicate that pardaxin has the potential to be a novel therapeutic agent to treat fibrosarcomas."
02/10/2015 - "We previously demonstrated that pardaxin has anti-tumor activity against murine fibrosarcoma, both in vitro and in vivo. "
08/01/2012 - "The antitumor activity of pardaxin, a fish antimicrobial peptide, has not been previously examined in in vitro and in vivo systems for treating murine fibrosarcoma. "
08/01/2012 - "Pardaxin, a fish antimicrobial peptide, exhibits antitumor activity toward murine fibrosarcoma in vitro and in vivo."
01/01/2011 - "In the present study, we examined the antitumor activity of pardaxin against human fibrosarcoma HT-1080 cells; pardaxin inhibited cell proliferation by inducing apoptosis, as demonstrated by an increase in the externalization of plasma membrane phosphatidylserine and the presence of chromatin condensation. "

02/10/2015 - "Local injection of pardaxin resulted in a significant reduction of perianal gland adenoma growth between 28 and 38 days post-treatment. "
02/10/2015 - "Our findings indicate that pardaxin has strong therapeutic potential for treating perianal gland adenomas in dogs. "
02/10/2015 - "The antimicrobial peptide pardaxin exerts potent anti-tumor activity against canine perianal gland adenoma."

02/10/2015 - "In this study, we examined the anti-tumor activity, toxicity profile, and maximally-tolerated dose of pardaxin treatment in dogs with different types of refractory tumor. "
08/01/2012 - "In this study, the antitumor activity of synthetic pardaxin was tested using murine MN-11 tumor cells as the study model. "
04/01/2014 - "Importantly, pardaxin treatment or c-FOS overexpression induced cell death in diverse cancer cell lines, indicating that pardaxin and c-FOS may possess therapeutic potential for use in cancer treatment."
04/01/2014 - "Overexpression of c-FOS caused a dramatic increase in cell death, while knockdown of c-FOS induced pardaxin resistance; such effects were observed in both an in vitro cell model and an in vivo xenograft tumor model. "
01/01/2011 - "The role of pardaxin in inducing apoptosis for preventing cancer has not yet been investigated. "

01/01/2014 - "In this study, we investigated whether pardaxin promoted healing of contaminated wounds in mice. "
01/01/2014 - "Pardaxin decreased MRSA bacterial counts in the wounded region and also enhanced wound closure. "
01/01/2020 - "Retraction for Huang et al., "Use of the Antimicrobial Peptide Pardaxin (GE33) To Protect against Methicillin-Resistant Staphylococcus aureus Infection in Mice with Skin Injuries"."
01/01/2014 - "Use of the antimicrobial peptide pardaxin (GE33) to protect against methicillin-resistant Staphylococcus aureus infection in mice with skin injuries."

08/01/2013 - "In this study, we used proteomic approaches and network reconstruction to clarify the mechanism of pardaxin-induced apoptosis in human cervical carcinoma HeLa cells. "
08/01/2013 - "Proteomic analysis reveals that pardaxin triggers apoptotic signaling pathways in human cervical carcinoma HeLa cells: cross talk among the UPR, c-Jun and ROS."