7-methylguanosine triphosphate

Also Known As:

7-methyl-GTP; 7-methylguanosine 5'-triphosphate; m(7)GTP; m7-GTP; 2-amino-6,9-dihydro-9-(5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-ribofuranosyl)-7-methyl-6-oxo-1H-purinium, hydroxide, inner salt

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gansukh, Enkhtaivan: 1 article (08/2016)
2.	Judy, Gopal: 1 article (08/2016)
3.	Kazibwe, Zakayo: 1 article (08/2016)
4.	Kim, Doo Hwan: 1 article (08/2016)
5.	Pandurangan, Muthuraman: 1 article (08/2016)
6.	Shi, Fang: 1 article (12/2015)
7.	Wan, Jing: 1 article (12/2015)
8.	Xu, Zhanzhan: 1 article (12/2015)
9.	Zhao, Min: 1 article (12/2015)
10.	Hatakeyama, Dai: 1 article (01/2013)

Related Diseases

1.	Human Influenza (Influenza) 01/01/2013 - "The presented conformation of m(7)GTP may be a clue for the anti-influenza drug-design." 08/15/2016 - "The blocking of polymerase basic protein subunits of influenza viral RNA polymerase by Q7G was detected by in silico molecular docking assays using AutoDock Vina program with m(7)GTP. " 05/27/2003 - "However, the potency of 7-methyl-GTP for cap binding inhibition was 200-fold stronger with eIF4E and had a higher contribution from the triphosphate moiety as compared to influenza RNP. "
2.	Ovarian Neoplasms (Ovarian Cancer) 12/01/2015 - "First the activation of eIF4E protein was detected with m7-GTP cap binding assays in ovarian cancer and control cells. "
3.	Hypoxia (Hypoxemia) 06/13/2008 - "Because internal ribosome entry sites (IRES) have been postulated to mediate this preferential synthesis, we analyzed the 5 '-untranslated regions from a panel of stress-regulated mRNAs for m(7)GTP cap-independent translation and identified putative IRES elements in encephalomyocarditis virus, vascular endothelial growth factor, hypoxia-inducible factors (HIFs) 1alpha and 2alpha, glucose transporter-like protein 1, p57(Kip2), La, BiP, and triose phosphate isomerase transcripts. "

Related Drugs and Biologics

1.	Eukaryotic Initiation Factor-4E
2.	Proteins (Proteins, Gene)
3.	Facilitative Glucose Transport Proteins (Glucose Transporter)
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	Protein Subunits (Protein Subunit)
6.	5' Untranslated Regions (5' UTR)
7.	Triose-Phosphate Isomerase (Triosephosphate Isomerase)
8.	Viral RNA
9.	Internal Ribosome Entry Sites
10.	triphosphoric acid (triphosphate)