methylamphotericin B (AME)

07/01/1984 - "In a model of deep stromal infection, the administration of topical 1% amphotericin B methyl ester was highly efficacious when the corneal epithelium was absent. "
07/01/1984 - "Quantitative mycologic techniques were used to evaluate the efficacy of topical amphotericin B methyl ester in two models of yeast infection in rabbit eyes. "
01/01/1988 - "These findings closely resemble the clinical and neuropathologic abnormalities that developed in patients during the first human trial of AME for treatment of fungal infections, but differ from those of animal studies that did not closely simulate the long-term drug administration required for antifungal therapy in humans. "
06/01/2015 - "Serious infections occurred more frequently in the AME group (53.0%) than in BME (28.4%) or CsA (25.5%) groups. "
01/01/2014 - "Xylanase supplementation increased AME values regardless of infection and apparent ileal digestibility of CP in challenged birds (P < 0.05). "

03/01/2007 - "Treatment of mice with 200, 250, 300, 350, and 400 mg/kg body weight of AME, orally once daily for 5 consecutive days before DOX treatment, significantly reduced the frequency of DOX-induced micronuclei accompanied by a significant elevation in the PCE/NCE ratio at all scoring times. "
02/01/2007 - "Therefore, further studies were carried out using this dose of AME, where the animals were administered with 250 mg/kg body weight of AME before exposure to 0, 0.5, 1, 2, 3 and 4 Gy of gamma-radiation and evaluated at 12, 24, 36 and 48 hours post-irradiation. "
12/01/2004 - "The acute toxicity study of AME showed that it was nontoxic up to a dose of 6 g/kg body weight, the highest drug dose that could be administered. "
06/01/2013 - "4. No differences were observed for body weight gain and feed intake or apparent metabolisable energy (AME) among all dietary treatment groups. "
02/01/2007 - "The greatest reduction in MPCE was observed for 250 mg/kg body weight AME, accompanied by the highest polychromatic erythrocyte to normochromatic erythrocyte ratio, in comparison with the non-drug-treated irradiated control. "

07/01/2008 - "This study supports the use of the AME intervention to encourage coping-related behaviors in hospitalized children aged 4-7 receiving cancer treatment."
07/01/2008 - "A non-randomized [corrected] controlled trial of the active music engagement (AME) intervention on children with cancer."
09/01/2001 - "Experiments with sensitive tumor types identified in these in vitro studies are currently ongoing in order to demonstrate the anticancer activity of AME in different animal tumor models."
09/01/2014 - "Italian Association of Clinical Endocrinologists (AME) position statement: a stepwise clinical approach to the diagnosis of gastroenteropancreatic neuroendocrine neoplasms."
01/01/2010 - "AME is an uncommon tumor that typically arises in breast, but rarely found in salivary glands, lung, and skin. "

06/01/2004 - "3. Xylanase supplementation significantly improved weight gain, feed efficiency and AME, irrespective of the wheat form used. "
06/01/2004 - "2. Birds given diets containing whole wheat had improved weight gains, feed efficiency and AME compared to those fed on diets containing ground wheat. "
06/01/2014 - "Moreover, a high-AME diet decreased feed cost per carcass weight gain from 8 to 55 d of age. "
06/01/2008 - "As dietary energy increased from 2,600 to 3,100 kcal of AME/kg, the weight gain of ducks increased significantly, and the feed intake and feed:gain decreased significantly. "
06/01/2006 - "4. The chickens fed on the Abbott cultivar wheat had a greater weight gain, although there were no differences in the determined AME of the two wheat cultivars. "

07/01/1979 - "Amphotericin B methyl ester: evaluation for intravitreous use in experimental fungal endophthalmitis."
04/01/1980 - "The maximum nontoxic dose of amphotericin B methyl ester in vitrectomy infusion fluid was found to be 75 microgram/ml. Experimentally induced fungal endophthalmitis in rabbits was cured by vitrectomy using infusion fluid that contained 10 microgram/ml of amphotericin B methyl ester."
04/01/1980 - "Toxicity and efficacy of vitrectomy fluids: amphotericin B methyl ester in the treatment of experimental fungal endophthalmitis."
12/01/1981 - "Intravenous amphotericin B(1.0 to 2.0 mg/kg on alternate days), IV amphotericin B methyl ester ascorbate (5.0 mg/kg/day), and oral ketoconazole (80 mg/kg/day reduced the severity of C albicans endophthalmitis when therapy was initiated seven days following injection of blastospores and continued for 28 days. "
12/01/2012 - "To compare in vitro susceptibility of amphotericin B (AMB) and amphotericin B methyl ester (AME) (a more soluble and less toxic formulation of AMB) against Candida albicans isolates recovered from human cases of endophthalmitis. "