locust bean gum (carob)

derived from the seeds of Ceratonia siliqua tree; straight chain polymer of mannose with one galactose on every fourth mannose; MW approx 310,000; RN given refers to cpd with unknown MF; see also record for GUAR GUM (supercol GF)

Also Known As:

Networked: 67 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Haber, B: 3 articles (04/2008 - 09/2001)
2.	Ragavan, Anpalaki J: 2 articles (03/2012 - 02/2010)
3.	Tomomasa, Takeshi: 2 articles (12/2006 - 05/2004)
4.	Miyazawa, Reiko: 2 articles (12/2006 - 05/2004)
5.	Kaneko, Hiroaki: 2 articles (12/2006 - 05/2004)
6.	Morikawa, Akihiro: 2 articles (12/2006 - 05/2004)
7.	Graubaum, H J: 2 articles (10/2003 - 09/2001)
8.	Harde, A: 2 articles (10/2003 - 09/2001)
9.	Lüder, W: 2 articles (10/2003 - 09/2001)
10.	Azcoitia, Iker: 1 article (12/2015)

Related Diseases

1.	Hypercholesterolemia 10/01/2003 - "Daily consumption of food products enriched with carob fibre shows beneficial effects on human blood lipid profile and may be effective in prevention and treatment of hypercholesterolemia." 09/01/2001 - "The carob preparation may have value in the dietary treatment of hypercholesterolemia." 09/01/2001 - "Carob pulp preparation for treatment of hypercholesterolemia." 09/01/2001 - "Over 8 weeks, 47 volunteers with moderate hypercholesterolemia (total cholesterol 232-302 mg/dL) consumed 15 g of carob per day in three products (breakfast cereal, fruit muesli bar, powdered drink) as a supplement to their regular diet. "
2.	Gastroesophageal Reflux (GERD) 06/01/2007 - "Effect of formula thickened with reduced concentration of locust bean gum on gastroesophageal reflux." 12/01/2006 - "HL-450, a thickened formula with typical commercially available concentrations of locust bean gum, slowed gastric emptying in infants with gastroesophageal reflux." 01/01/2005 - "Re: Effect of locust bean gum in anti-regurgitant milk on the regurgitation in uncomplicated gastroesophageal reflux." 05/01/2004 - "Effect of locust bean gum in anti-regurgitant milk on the regurgitation in uncomplicated gastroesophageal reflux." 01/01/2003 - "To study the effect of carob bean gum on gastric emptying and to symptoms of regurgitation, we recruited 20 full term Thai infants (mean age=13.4+/-7 week; mean body weight=4943+/-1272gm) without pathological gastroesophageal reflux. "
3.	Body Weight (Weight, Body) 06/01/2012 - "The results of the experiment showed that the dietary addition of 75 or 100 g/kg carob pods increased body weight at slaughter and carcass weight. " 06/01/2006 - "These results indicate that carob fiber might exert beneficial effects in energy intake and body weight." 07/01/1992 - "6. The length of small intestine, large intestine and caeca and the weight of gizzard expressed per kg of body weight increased with an increase in the level of carob pods meal, which is rich in fibre, in the diets." 01/01/2003 - "To study the effect of carob bean gum on gastric emptying and to symptoms of regurgitation, we recruited 20 full term Thai infants (mean age=13.4+/-7 week; mean body weight=4943+/-1272gm) without pathological gastroesophageal reflux. " 06/01/1983 - "Depressions in body-weight gain greater than 10% for dosed groups relative to their respective control groups were observed for male (low dose only) and female mice fed diets containing agar, female mice fed diets containing guar gum (high dose only), male mice fed diets containing locust-bean gum (high dose only) and male and female mice fed diets containing tara gum (high dose only). "
4.	Weight Gain 11/01/1998 - "No significant differences were observed for live weight, although the carob group ate 14% more dry matter, showing a higher conversion index (2.68 and 3.22kg dry matter per kg weight gain respectively for control and carob). " 01/01/2003 - "There were statistically significant improvements in symptoms of vomiting (a smaller quantity P<0.001 and frequency of vomiting P<0.0001) and improvements in weight gain per week (W1=121.2+106.9gm, W2=221.3+136.1gm; P=0.005) when infants consumed the carob bean formula. " 01/01/2010 - "One small study found no evidence of benefit on frequency of regurgitation or weight gain after treatment with cisapride versus no treatment, carob bean or corn syrup thickeners. " 01/01/2003 - "Afterwards, carob bean infant formula was given for 2-4 weeks and weight gain, vomiting symptoms, night cough, colic, flatus, defaecation character and T 1/2 GET were assessed. "
5.	Cough 03/13/2012 - "Displacement of 0.4mL of simulated mucus prepared with viscoelastic properties similar to healthy individuals (syrup-like) or patients with COPD (gel-like) using locust bean gum(LBG) solution (0.38g LBG in 100mL water) cross-linked with 3mL or 12mL borax solution (0.02 molar), respectively were measured inside trachea during coughs of 300ms at low cough velocity (15±0.5m/s) generated using a computer controlled solenoid valve. " 01/01/1987 - "The relationships between mucus rheology, depth of mucus layer and clearance by simulated cough were examined in a study employing a model plexiglass trachea lined with gels formed from locust bean gum crosslinked with sodium tetraborate. " 01/01/2003 - "Afterwards, carob bean infant formula was given for 2-4 weeks and weight gain, vomiting symptoms, night cough, colic, flatus, defaecation character and T 1/2 GET were assessed. "

Related Drugs and Biologics

1.	Cisapride (Propulsid)
2.	Gels
3.	sodium borate (sodium tetraborate)
4.	galactomannan
5.	Carbohydrates
6.	borax
7.	guar gum (guaran)
8.	Tannins (Tannic Acid)
9.	Superoxide Dismutase
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Fluid Therapy (Oral Rehydration Therapy)