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5-hydroxycytosine

Also Known As:

2,5-Pyrimidinedione, 4-amino-1,6-dihydro-

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Cytosine: 1880
        5-hydroxycytosine: 7

Experts

1.	Cellai, Filippo: 1 article (09/2020)
2.	Ceni, Elisabetta: 1 article (09/2020)
3.	Galli, Andrea: 1 article (09/2020)
4.	Giese, Roger W: 1 article (09/2020)
5.	Godschalk, Roger: 1 article (09/2020)
6.	Munnia, Armelle: 1 article (09/2020)
7.	Peluso, Marco: 1 article (09/2020)
8.	Tarocchi, Mirko: 1 article (09/2020)
9.	van Schooten, Frederik Jan: 1 article (09/2020)
10.	Bohr, Vilhelm A: 1 article (06/2010)

Related Diseases

1.	Werner Syndrome (Werner's Syndrome) 06/04/2010 - "NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII, is a DNA glycosylase that repairs ring-fragmented purines, saturated pyrimidines and several oxidative lesions like 5-hydroxyuracil, 5-hydroxycytosine, etc. Previous studies from our laboratory have shown that Werner Syndrome protein (WRN), one of the five human RecQ helicases, stimulates NEIL1 DNA glycosylase activity on oxidative DNA lesions. "
2.	Dehydration (Water Stress) 04/15/1986 - "5-Hydroxycytosine obviously resulted from dehydration of cytosine glycol, and 5,6-dihydroxyuracil from deamination of 5,6-dihydroxycytosine. " 01/01/2008 - "The half-life of cytosine glycols in poly(dG-dC) was 6.5 h giving a ratio of dehydration to deamination of 5:1. At high substrate concentrations, the excision of cytosine glycols from poly(dG-dC) by purified endonuclease III was comparable to that of uracil glycols, whereas the excision of these substrates was 5-fold greater than that of 5-hydroxycytosine. "
3.	Prostatic Neoplasms (Prostate Cancer) 08/01/2004 - "Using liquid chromatography/mass spectrometry and gas chromatography/mass spectrometry, we show increased levels of oxidative DNA base lesions, 8-hydroxyguanine (8-oxoG), 8-hydroxyadenine (8-oxoA) and 5-hydroxycytosine (5OHC) over the baseline in PC-3 and DU-145 prostate cancer cells following exposure to ionizing radiation and a repair period. "
4.	Neoplasms (Cancer) 03/01/2003 - "A weak, but distinct effect of tumor grading and metastatic status was observed in both kinds of tissue in the case of 5-hydroxyuracil, 5-hydroxycytosine, 7,8-dihydro-8-oxoguanine, 7,8-dihydro-8-oxoadenine. "
5.	Inflammation (Inflammations) 06/01/2008 - "Inflammation-mediated, neutrophil-derived hypochlorous acid can damage DNA and result in the chlorination damage products 5-chlorocytosine and 5-chlorouracil as well as the oxidation damage products 5-hydroxycytosine and 5-hydroxyuracil. "

Related Drugs and Biologics

1.	5-hydroxyuracil
2.	RecQ Helicases
3.	DNA Glycosylases (DNA Glycosylase)
4.	A-Form DNA (A-DNA)
5.	Deoxyribonuclease (Pyrimidine Dimer)
6.	Pyrimidines
7.	Purines
8.	Proteins (Proteins, Gene)
9.	DNA (Deoxyribonucleic Acid)
10.	8-hydroxyadenine

Related Therapies and Procedures

1.	Ligation