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hemoglobin Presbyterian

low oxygen affinity; Asn replaced by Lys at position beta 108(G10)

Also Known As:

Hb Presbyterian

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin Presbyterian: 4
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin Presbyterian: 4

Experts

1.	Shirasawa, Takuji: 3 articles (11/2005 - 07/2002)
2.	Shimizu, Takahiko: 2 articles (11/2005 - 07/2002)
3.	Tamaki, Masakatsu: 2 articles (10/2003 - 07/2002)
4.	Huang, Fei: 1 article (11/2005)
5.	Nojiri, Hidetoshi: 1 article (11/2005)
6.	Homma, Ikuo: 1 article (10/2003)
7.	Iwase, Michiko: 1 article (10/2003)
8.	Izumizaki, Masahiko: 1 article (10/2003)
9.	Kimura, Hiroshi: 1 article (10/2003)
10.	Suzuki, Yo-Ichi: 1 article (10/2003)

Related Diseases

1.	Sepsis (Septicemia) 11/01/2005 - "A novel lower-affinity hemoglobin (Hb) variant, Hb Presbyterian, enhances oxygen release to peripheral tissues and may improve tissue oxygen supply during sepsis. "
2.	beta-Thalassemia (Cooley's Anemia) 01/01/1985 - "DNA haplotype constellations of the beta-globin gene cluster have been analyzed in German families with hemoglobinopathies (Hb Freiburg, Hb Köln, Hb Presbyterian) and beta-thalassemias. "
3.	Splenomegaly 07/26/2002 - "On the other hand, homozygous mice exclusively expressed Hb Presbyterian in 100% of peripheral blood associated with hemolytic anemia, Heinz body formation, and splenomegaly. "
4.	Hypercapnia 10/01/2003 - "The effects of decreased hemoglobin (Hb)-O2 affinity on ventilatory responses during hypercapnia (0, 5, 7, and 9% CO2 in O2) and hypoxia (10 and 15% O2 in N2) were assessed in mutant mice expressing Hb Presbyterian (mutation in the beta-globin gene, beta108 Asn --> Lys). "
5.	Hemoglobinopathies 01/01/1985 - "DNA haplotype constellations of the beta-globin gene cluster have been analyzed in German families with hemoglobinopathies (Hb Freiburg, Hb Köln, Hb Presbyterian) and beta-thalassemias. "

Related Drugs and Biologics

1.	beta-Globins (beta Globin)
2.	Hemoglobins (Hemoglobin)
3.	Oxygen (Dioxygen)
4.	DNA (Deoxyribonucleic Acid)
5.	hemoglobin Freiburg