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7-ethoxycoumarin

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        7-ethoxycoumarin: 16
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        7-ethoxycoumarin: 16

Experts

1.	Kulikova, L N: 1 article (05/2004)
2.	Lee, S H: 1 article (12/2000)
3.	Lee, S M: 1 article (12/2000)
4.	Lee, Y G: 1 article (12/2000)

Related Diseases

1.	Liver Diseases (Liver Disease) 07/01/1985 - "The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease." 08/01/1979 - "The activity of 7-ethoxycoumarin 0-deethylase and associated NADPH-cytochrome c reductase was determined in 9000 g supernatant from bioptically obtained liver specimens from patients with various liver diseases in order to study in vitro drug metabolising capacity. "
2.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 07/01/1985 - "Using 7-ethoxycoumarin as a probe substrate, microsomal monoxygenase activity has been measured in liver tissue from patients with primary biliary cirrhosis (PBC) of varying histological severity, and in histologically normal control tissue. " 07/01/1985 - "The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease."
3.	Starvation 10/12/1990 - "7-Ethoxycoumarin O-dealkylation and aniline hydroxylation activities of the renal microsomes of control male rats were very low but were induced 2.5-3-fold by 72 h starvation. " 04/01/1990 - "P450 DM (P450j) was induced 2.5-fold by a 48-h starvation and its increase reflected the increase of metabolic activity of hepatic microsomes toward aniline, 7-ethoxycoumarin, and N-nitrosodimethylamine. " 05/01/1986 - "The cytochrome P-450 content in liver cells from rainbow trout was not affected by starvation for 12 weeks whereas the rate of cytochrome P-450-dependent deethylation of 7-ethoxycoumarin in liver cells from 6 or 12 weeks starved fish was 60% of the rate in fed fish. "
4.	Infections 05/26/2023 - "7-Ethoxycoumarin rescued Caenorhabditis elegans from infection of COPD derived clinical isolate Pseudomonas aeruginosa through virulence and biofilm inhibition via targeting Rhl and Pqs quorum sensing systems." 06/01/1986 - "During infection, 7-ethoxycoumarin deethylase (7ECdeEt'ase) and ethylmorphine demethylase (EMdeMe'ase) (monooxygenases), and NADPH cytochrome c reductase (NADPH c red'ase) were measured in liver microsomes. "
5.	Hepatocellular Carcinoma (Hepatoma) 05/01/2004 - "Microsomes isolated from hepatoma 61 transplanted to mice treated with either pyrazole or cobalt chloride catalyzed oxidation of coumarin and 7-ethoxycoumarin at rates 2-2.5-fold higher than in saline controls. " 01/01/1985 - "The carbon monoxide-reduced difference spectral peak of hepatoma P-450MCI was at 446.5 nm, whereas the peak of hepatoma P-450MCII was at 451 nm. In the reconstituted system, hepatoma P-450MCI catalyzed 3-hydroxylation of benzo[a]pyrene and O-deethylation of 7-ethoxycoumarin, but showed low activities for N-demethylation of benzphetamine and aminopyrine, O-demethylation of p-nitroanisole, and p-hydroxylation of aniline. "

Related Drugs and Biologics

1.	NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
2.	Cytochrome P-450 Enzyme System (Cytochrome P450)
3.	aniline (aniline hydrobromide)
4.	Benzphetamine (Benzfetamine)
5.	Benzo(a)pyrene
6.	Aminopyrine (Aminophenazone)
7.	Glucuronides
8.	Xenobiotics
9.	Sulfates (Sulfates, Inorganic)
10.	NADP (NADPH)