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estrone sulfate (Evex)

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sulfoconjugated estrone; RN given refers to parent cpd

Also Known As:

Evex; estrone sulfate, 14C-labeled; estrone sulfate, 16-(14)C-labeled; estrone sulfate, ammonium salt; estrone sulfate, potassium salt; estrone sulfate, sodium salt; estrone-3-sulfate; oestrone sulphate; potassium estrone sulfate; sodium estrone sulfate

Networked: 208 relevant articles (5 outcomes, 32 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hankinson, Susan E: 7 articles (10/2014 - 11/2002)
2.	Tworoger, Shelley S: 6 articles (10/2014 - 04/2006)
3.	Tamai, Ikumi: 5 articles (04/2015 - 12/2004)
4.	Eliassen, A Heather: 4 articles (10/2014 - 04/2006)
5.	Geisler, Jürgen: 4 articles (02/2010 - 09/2003)
6.	Purohit, A: 4 articles (07/2007 - 01/2000)
7.	Reed, M J: 4 articles (07/2007 - 01/2000)
8.	Nakanishi, Takeo: 3 articles (04/2015 - 10/2010)
9.	Dowsett, Mitch: 3 articles (08/2012 - 10/2006)
10.	Nozawa, Takashi: 3 articles (10/2010 - 12/2004)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 06/01/1990 - "The reduction of estrone sulfate may be beneficial for the action of MA against breast cancer." 10/01/2010 - "The purpose of the present study is to identify the transporter(s) responsible for the uptake of estrone-3-sulfate in breast cancer cells. " 04/22/1993 - "Accordingly, the present study examined the dose relationship of estrone sulfate to a variety of biologic endpoints in MCF-7 breast cancer cells in culture. " 05/01/1951 - "Tracer studies of radioactive sodium estrone sulfate (S35) in cases of advanced breast cancer." 10/01/2010 - "We previously showed that estrone-3-sulfate transporters are present in human breast cancer-derived MCF-7 cells (J. "
2.	Neoplasms (Cancer) 05/12/2007 - "The milk group showed a significantly great incidence (75%) in tumor development compared with the water group (38%) and was comparable to the estrone sulfate group (69%). " 01/01/2007 - "Conversion of circulating estrone sulfate to 17beta-estradiol by ovarian tumor tissue: a possible mechanism behind elevated circulating concentrations of 17beta-estradiol in postmenopausal women with ovarian tumors." 07/15/1990 - "By comparison, estrone sulfate infusions significantly increased tumor volume over that observed in castrate animals on both days 7 and 14 of infusion. " 10/01/1987 - "The biological responses, the metabolism and the ultrastructural modifications provoked by estrone sulfate in the MCF-7 mammary cancer cell line are studied. " 01/01/1985 - "In tissue homogenates incubated with 5-25 microM [3H] oestrone sulphate at 37 degrees much higher capacities for hydrolysis (nmol/g tissue/hr) were demonstrated with a Km of 2-16.5 microM: cancers (34-394) and benign tissues (9-485) had significantly higher sulphatase activities than adipose tissues (9-39). "
3.	Breast Cyst 01/01/2000 - "In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. " 03/01/1990 - "Levels of oestrone sulphate in breast cyst fluids (1.5-744.0 nmol/l) were also generally in excess of those in plasma (2.0-59.9 nmol/l) and again no relationship was evident between concentrations in cyst fluid and the circulation. " 03/01/1990 - "Plasma and cyst fluid were obtained from patients with palpable breast cysts and analysed for androgen conjugates and oestrone sulphate content by radioimmunoassay. " 03/01/1990 - "Levels of androgen conjugates and oestrone sulphate in patients with breast cysts." 01/01/1990 - "Estrone-3-sulfate in human breast cyst fluid. "
4.	Leiomyoma (Uterine Fibroids) 09/01/1990 - "The tissue concentration of estrone sulfate was higher in leiomyoma tissues. " 06/01/1990 - "In this study, estrone sulfatase (E1SF) activity and concentrations of estrone (E1) and estrone sulfate (E1S) were measured in endometrial, leiomyoma, and myometrial tissues of the same human uterus (n = 11) with a leiomyoma. " 09/01/1990 - "These results suggest that estrone sulfate is hydrolyzed mainly by estrone sulfatase in the endometrium and myometrium surrounding leiomyoma nodes and the estrone formed may affect the growth of leiomyoma." 09/01/1990 - "In this study, we investigated both the estrone formation (estrone sulfatase activity) and the transformation from estrone to estrone sulfate (estrone sulfotransferase activity) in human leiomyoma tissue. "
5.	Birth Weight (Birth Weights) 01/08/1999 - "A total of 54 Holstein-Friesian cows (13 primiparous and 41 multiparous) was used to study maternal plasma oestrone sulphate (E1S) during pregnancy and its relationship to birth weight and viability of calves and time required for placental expulsion after calving. " 10/15/2014 - "The aim of this article was to compare plasma estrone sulfate (E1SO4), clinical biochemistry, and milk yield of dairy cows carrying a female fetus from a bull (BULL) or from its clone (CLONE), evaluating also the relationship between the former variables and the birth weight of the newborn. " 08/01/2009 - "Maternal plasma oestrone sulphate concentration prior to parturition in relation to birth weight of the calf in primiparous, 2-year-old, Angus heifers." 10/01/2003 - "They also suggest that the plasma concentration of estrone sulfate is associated with the breed of pregnant cow and that its concentration is also affected by calf birth weight depending on the breed of bull. " 10/01/2003 - "There was no significant relationship between estrone sulfate concentration and duration of gestation, calf birth weight, weight of placenta or viability of newborn calves. "

Related Drugs and Biologics

1.	Estradiol (Estrace)
2.	Estrone (Folliculin)
3.	Hormones
4.	Dehydroepiandrosterone Sulfate
5.	Testosterone (Sustanon)
6.	Estrogens (Estrogen)
7.	Prolactin
8.	Sex Hormone-Binding Globulin
9.	Megestrol Acetate (Borea)
10.	estrone sulfatase

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Injections
3.	Ovariectomy (Oophorectomy)
4.	Mastectomy (Mammectomy)
5.	Intravenous Injections