chlornaltrexamine

RN given refers to (5alpha,6beta)-isomer

Also Known As:

6 beta-(N,N-bis(2-chloroethyl)amino)-17-(cyclopropylmethyl)-4,5 alpha-epoxy-3,14-dihydroxy morphinan; alpha-chlornaltrexamine; beta-CNA; beta-chlornaltrexamine; beta-chloronaltrexamine; chlornaltrexamine hydrochloride; Morphinan-3,14-diol, 6-(bis(2-chloroethyl)amino)-17-(cyclopropylmethyl)-4,5-epoxy-, (5alpha,6beta)-

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Bites and Stings (Sting) 12/01/1987 - "In Experiment 2 we showed that LTA was prevented by naloxone or beta-chlornaltrexamine given before exposure (50 bites) on Day 1. Results of Experiment 3 revealed that naloxone or beta-chlornaltrexamine injected before reexposure to seven bites on Day 2 antagonized LTA measured 10 min, but not 1 min, after reexposure. " 01/01/1989 - "A low number of bites induced an analgesia that was reversed by beta-chlornaltrexamine but not by naloxone, and that correlated positively with increased displays of defensive upright and immobility upon contact with the opponent. " 01/01/1988 - "The effective inhibition of the antinociceptive response following low and high number of bites by the alkylating opiate antagonist beta-chlornaltrexamine suggests participation of opioid mechanisms at both stress levels. "
2.	Weight Loss (Weight Reduction) 04/13/1987 - "An additional experiment indicated that the weight loss after beta-CNA treatment could be completely accounted for by the reduction in intake. " 10/14/1983 - "Treatment with beta-CNA before morphine treatment antagonized naloxone-induced expression of withdrawal for all signs observed, except weight loss. "
3.	Neuroblastoma 07/01/1981 - "Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine."
4.	Hypothermia 03/12/1981 - "Chlornaltrexamine (beta-CNA) a selective, long-acting irreversible opiate antagonist inhibited the analgesia, hypothermia, hypothermia tolerance and physical dependence produced by delta 9-tetrahydrocannabinol (THC) in rats. "
5.	Glioma (Gliomas) 07/01/1981 - "Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine."

Related Drugs and Biologics

1.	Naloxone (Narcan)
2.	Opiate Alkaloids
3.	Opioid Analgesics (Opioids)
4.	chlornaltrexamine
5.	Opioid Peptides (Opioid Peptide)
6.	Dronabinol (THC)
7.	Opioid Receptors (Opioid Receptor)
8.	Morphine (MS Contin)

Related Therapies and Procedures

1.	Analgesia
2.	Injections