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apraclonidine (Iopidine)

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relieves postoperative intraocular pressure following trabeculoplasty; RN given refers to parent cpd

Also Known As:

Iopidine; 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine; 4-aminoclonidine; ALO 2145; ALO-2145; Alcon brand of apraclonidine hydrochloride; Allphar brand of apraclonidine hydrochloride; Iopimax; apraclonidine hydrochloride; p-aminoclonidine; para-aminoclonidine

Networked: 117 relevant articles (13 outcomes, 20 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Imidazoles: 107
      - Imidazolines: 19
        Clonidine: 3708
        apraclonidine: 117

Experts

1.	Brown, Sandra M: 3 articles (06/2005 - 08/2003)
2.	Cambron, Melissa: 2 articles (04/2014 - 10/2011)
3.	Crevits, Luc: 2 articles (04/2014 - 10/2011)
4.	Maertens, Heidi: 2 articles (04/2014 - 10/2011)
5.	Hsiao, Chih-Hsien: 2 articles (09/2006 - 06/2006)
6.	Chen, Jiann-Torng: 2 articles (09/2006 - 06/2006)
7.	Lu, Da-Wen: 2 articles (09/2006 - 06/2006)
8.	Chen, Po-Liang: 2 articles (09/2006 - 06/2006)
9.	Freedman, Kenn A: 2 articles (06/2005 - 08/2003)
10.	Bursztyn, Lulu L C D: 1 article (09/2015)

Related Diseases

1.	Glaucoma 10/01/1995 - "Short-term efficacy of apraclonidine hydrochloride added to maximum-tolerated medical therapy for glaucoma. " 10/01/1997 - "This study describes our long-term experience with apraclonidine 0.5% in the treatment of chronic glaucoma in clinical practice. " 12/01/1995 - "To evaluate the effect of the chronic use of apraclonidine 0.5% on the intraocular pressure (IOP) of patients with glaucoma; also, to study the side effect profile of this drug when used chronically. " 06/01/2009 - "In all, 115 eyes of 75 pediatric glaucoma patients received apraclonidine 0.5% drops, for a total 179 treatment sessions. " 06/01/2009 - "Here we evaluate the safety of topical apraclonidine 0.5% when used in children with glaucoma. "
2.	Open-Angle Glaucoma (Glaucoma, Open Angle) 04/01/1999 - "Apraclonidine 0.5% appears to be effective in reduction of post-dilated IOP increases in patients with chronic open-angle glaucoma." 04/01/1999 - "The purpose of this study is to determine the effectiveness of 0.5% apraclonidine in reversing IOP increases after pupillary dilation in patients with chronic open-angle glaucoma. " 11/01/1997 - "This study consisted of 231 consecutive eyes of patients with primary open-angle glaucoma undergoing ALT: 70 eyes (30%) were started on a regimen including chronic apraclonidine 0.5% use (group A) and 161 eyes (70%) were started on a regimen without chronic apraclonidine 0.5% use (group B). " 04/01/1999 - "Apraclonidine 1.0% has been shown to reverse the potential intraocular pressure (IOP) increase after pupil dilation IOP increases in patients with chronic open-angle glaucoma. " 04/01/1999 - "Reversal of intraocular pressure increases with 0.5% apraclonidine after dilated fundus examination in patients with chronic open-angle glaucoma."
3.	Horner Syndrome (Horner's Syndrome) 09/01/2006 - "Efficacy of apraclonidine 0.5% in the diagnosis of Horner syndrome in pediatric patients under low or high illumination." 09/01/2006 - "The application of apraclonidine in pediatric patients is safe and effective in the diagnosis of Horner syndrome. " 06/01/2006 - "The application of 0.5% apraclonidine in pediatric patients is safe and effective in the diagnosis of Horner syndrome." 03/01/2010 - "A review of all reported cases of apraclonidine testing in Horner syndrome suggests that this is a promising diagnostic adjunct that must be validated in larger studies." 01/01/2009 - "This study aimed at developing through three clinical cases, the usefulness of topical apraclonidine 0.5% to confirm a diagnosis of Bernard-Horner syndrome. "
4.	Hypersensitivity (Allergy) 09/01/1993 - "Long-term therapy for some patients may be inhibited by ocular allergy for which there was a higher incidence to the 0.5% apraclonidine solution than to the 0.25% solution in this study. " 04/01/2012 - "No differences were observed between the preoperative [0.40 (SD 0.07)] and 1-month basal values [0.38 (SD 0.07)], and instillation of apraclonidine no longer induced a hypersensitivity response. " 06/01/2000 - "Forty-five patients were identified with a significant allergic reaction to apraclonidine that resulted in drug discontinuation. " 06/01/2000 - "A retrospective chart review was performed to identify patients who had demonstrated an allergic reaction to apraclonidine of sufficient severity to result in drug discontinuation. " 01/01/1998 - "For the 10 patients rechallenged with apraclonidine, the mean time to allergy was 13.6 +/- 10.2 days (range 3-32 days). "
5.	Ocular Hypertension (Glaucoma, Suspect) 04/01/1999 - "We studied the acute effects of the ocular hypotensive drug, apraclonidine (AP), on intraocular pressure (IOP) and aqueous humor dynamics of anesthetized rats during infusion-induced ocular hypertension. " 09/01/1993 - "Apraclonidine effectively lowers IOP associated with open-angle glaucoma or ocular hypertension; these pilot results will need to be confirmed by a larger pivotal study. " 07/01/1991 - "The short-term additive effect and side effects of adding 1% apraclonidine hydrochloride to nonselective beta-blockers were investigated in 21 patients with ocular hypertension or early primary open-angle glaucoma. " 09/01/1993 - "To compare the safety and efficacy of apraclonidine ophthalmic solution 0.25% and 0.5% (both given 3 times daily) to timolol maleate (0.5%) given twice daily, in primary open-angle glaucoma or ocular hypertension. " 10/01/1991 - "Seventeen patients (15 with primary open-angle glaucoma, 1 with pigmentary glaucoma, and 1 glaucoma suspect) on long-term timolol treatment in both eyes received a single dose of apraclonidine in one eye and a placebo in the other. "

Related Drugs and Biologics

1.	apraclonidine (Iopidine)
2.	Cocaine (Cocaine HCl)
3.	Silicon
4.	Clonidine (ST 155)
5.	Timolol (Blocadren)
6.	Ophthalmic Solutions (Eye Drops)
7.	dorzolamide (Trusopt)
8.	brimonidine (Alphagan)
9.	Acetazolamide (Diamox)
10.	Excitatory Amino Acids

Related Therapies and Procedures

1.	Phacoemulsification
2.	Cataract Extraction
3.	Laser In Situ Keratomileusis (LASIK)
4.	Lasers (Laser)
5.	Denervation