nizofenone

10/01/1984 - "Nizofenone became effective in lowering brain water content after 24 hr following ischemia. "
09/01/1994 - "Nizofenone (10 mg/kg i.p.) significantly inhibited neuronal cell death in the hippocampus CA1 pyramidal cells 7 days after 15 min of ischemia caused by 4-vessel occlusion. "
10/01/1984 - "In the animals treated with nizofenone (30 mg/kg i.p.) and PBT (60 mg/kg i.p.), water content was significantly lower than that of the control group at 24 hr and 1.5-24 hr after ischemia, respectively. "
01/01/1988 - "Nizofenone showed similar effects in another experiment in which cerebral metabolic disorder was induced by complete ischemia following decapitation. "
07/01/1985 - "Pretreatment of the animals with nizofenone resulted in a marked suppression of both FFA liberation and ATP depletion during ischemia. "

01/01/1988 - "Brain protection against oxygen deficiency by nizofenone."
01/01/1988 - "These findings suggest that nizofenone has a considerable cerebroprotective action against oxygen deficiency."
01/01/1988 - "The cerebral protective effect of nizofenone against tissue oxygen deficiency was investigated in mice. "
12/01/1984 - "These results suggest that the ameliorative effect of nizofenone on the recovery of neuronal functions is due to its ability to protect neurons against ischemic anoxia and to prevent interruption of postischemic circulation, and also the good recovery of rCBF is due to its ability to protect vasculature against ischemic anoxia."
03/01/1985 - "Effects of nizofenone, an agent which has been known to have a protective effect against experimental cerebral ischemia or anoxia, on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers were studied. "

11/01/1982 - "Histological examination of the state of vasogenic edema revealed that the perivascular exudation of plasma fluid in the infarcted area was definitely less in the Y-9179 treated group than in the other groups. "
04/01/1982 - "Y-9179 had no significant action on the course of the rCBF but its anti-edema effect might be related to its cerebral protective action. "
10/01/1984 - "The above results suggest that nizofenone may be effective in ameliorating ischemic cerebral edema, particularly vasogenic edema, and that this may be partially related to its cerebral protective action."
01/01/1993 - "Nizofenone is a potent neuroprotective drug which ameliorates this imbalance and also various pathophysiologic events during ischemia, such as ATP depletion, lactate accumulation, glutamate release, free fatty acid liberation, edema, and neuronal degeneration; in particular, ischemia-induced excessive glutamate release has been completely blocked by this drug. "

11/01/1984 - "[An experimental study on the protective effect of nizofenone in cerebral ischemia]."
12/01/1984 - "[Effect of nizofenone on pyramidal response, electrocorticogram and regional cerebral blood flow following recirculation after complete global brain ischemia in cats]."
06/01/1984 - "[Effect of nizofenone (Y-9179) on experimental cerebral ischemia in Mongolian gerbils]."
11/01/1984 - "Using the "canine model of complete ischemic brain regulated with a perfusion method" in which it is possible to control the degree of blood flow to a cerebral hemisphere via a perfusion pump, the protective effects of nizofenone against cerebral ischemia was investigated. "
03/01/1985 - "Effects of nizofenone, an agent which has been known to have a protective effect against experimental cerebral ischemia or anoxia, on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers were studied. "

01/01/2013 - "Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice."
01/01/2013 - "The present study was aimed to investigate the effects of nizofenone administration on the chronic restraint stress-induced cognitive impairments in mice. "
01/01/2013 - "Collectively, the present results suggested the potential of nizofenone in attenuating the CRS-induced cognitive impairments."