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alpha- (3- aminopropyl)- 3,4- dimethoxy- alpha- (1- methylethyl)benzeneacetonitrile (D 620)

N-demethylated analog of verapamil

Also Known As:

D 620; D-620

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenethylamines: 28
      - Verapamil: 6163
        alpha-(3-aminopropyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile: 2

Related Diseases

1.	Schizophrenia (Dementia Praecox) 11/01/1988 - "Cerebrospinal fluid (CSF) and plasma levels of verapamil and its two metabolites, norverapamil and D-620, were measured in seven patients with schizophrenia under steady-state conditions. "
2.	Retinoblastoma (Glioblastoma, Retinal) 05/10/1998 - "This deregulation of the cell cycle was not solely dependent on E1A inactivation of Rb, since similar effects were seen in Ad12 d/620-infected retinoblastoma (Y-79) cells, implicating p107 and p130 in E1A-mediated changes in cell cycle progression. "
3.	Neoplasms (Cancer) 05/10/1998 - "Human tumor (A549, KB, and HeLa) cells were infected with Ad12 d/620, a mutant virus which has a lesion in the E1B gene and essentially expresses only E1A. "

Related Drugs and Biologics

1.	Verapamil (Calan)
2.	norverapamil (D 591)