sulforafan (sulforaphane)

01/01/2012 - "D, L-Sulforaphane (SFN), a synthetic racemic analog of broccoli constituent L-sulforaphane, is a highly promising cancer chemopreventive agent with in vivo efficacy against chemically-induced as well as oncogene-driven cancer in preclinical rodent models. "
01/01/2004 - "Sulforaphane (SFN), a constituent of cruciferous vegetables, is highly effective in affording protection against chemically induced cancers in animal models. "
01/01/2013 - "We show here for the first time that sulforaphane treatment resulted in a significant reduction in the tumor growth of orthotopically implanted primary pancreatic CSCs isolated from human pancreatic tumors into the pancreas of NOD/SCID/IL2Rgamma mice, which is mediated through the modulation of Sonic hedgehog-GLI signaling. "
01/01/2015 - "We have shown that sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells. "
02/01/2013 - "Based on these promising results, the first prospective clinical studies with cancer patients and sulforaphane-enriched broccoli sprouts have now been initiated in the United States."

09/01/2014 - "Although the mode of action of sulforaphane has been extensively studied in cell and animal models and a multiple of mechanisms that could underpin its protective effects have been proposed, recent evidence from human intervention studies suggests that sulforaphane is involved in a complex interplay between redox status and metabolism to result in a tissue environment that does not favour prostate cancer progression. "
04/01/2014 - "D,L-Sulforaphane (SFN) is a promising chemopreventive agent with in vivo efficacy against prostate cancer in experimental rodents. "
04/01/2015 - "A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer."
06/01/2006 - "In conclusion, the present study indicates that induction of autophagy represents a defense mechanism against sulforaphane-induced apoptosis in human prostate cancer cells. "
06/01/2006 - "The present study reports a novel response to sulforaphane, a highly promising anticancer constituent of several edible cruciferous vegetables, in PC-3 and LNCaP human prostate cancer cells involving induction of autophagy. "

01/01/2012 - "Thus Sulforaphane potentially represents an inexpensive, safe and effective alternative for the management of pancreatic cancer."
01/01/2011 - "Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function."
01/01/2012 - "Thus, the objective of this study was to investigate the role of Shh pathway in pancreatic cancer and to examine the molecular mechanisms by which sulforaphane (SFN), an active compound in cruciferous vegetables, inhibits self-renewal capacity of human pancreatic CSCs. "
03/30/2014 - "Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication."
01/01/2013 - "Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway."

08/28/2014 - "However, the molecular mechanisms by which sulforaphane suppresses inflammation and carcinogenesis are yet to be fully elucidated. "
08/01/2014 - "In conclusion, sulforaphane at physiological concentrations protects against TNF-α-induced vascular endothelial inflammation, in both in vitro and in vivo models. "
08/01/2014 - "Furthermore, sulforaphane inhibited TNF-α-induced nuclear factor (NF)-κB transcriptional activity, Inhibitor of NF-κB alpha (IκBα) degradation and subsequent NF-κB p65 nuclear translocation in endothelial cells, suggesting that sulforaphane can inhibit inflammation by suppressing NF-κB signaling. "
08/01/2014 - "Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway."
11/01/2013 - "CNIs also activated an Nrf2/HO-1-dependent compensatory response and the Nrf2 activator sulforaphane inhibited JAK2 and JNK activation and inflammation. "

01/01/2015 - "In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential. "
01/01/2015 - "The L-sulforaphane (SFN) component of broccoli sprout showed anticancer activity in several preclinical studies including breast cancer. "
03/01/2007 - "These results support testing sulforaphane in vivo and warrant future studies examining the clinical potential of sulforaphane in human breast cancer."
12/01/2013 - "Sulforaphane inhibits growth of phenotypically different breast cancer cells."
02/01/2012 - "D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc."