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somatomedin B
not the same as sulfation factor it is growth hormone dependent and has trypsin inhibitor activity; see also record for somatomedin A
Networked:
9
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Intercellular Signaling Peptides and Proteins: 29768
Insulin-Like Peptides: 7371
Somatomedins: 271
somatomedin B: 9
Blood Proteins: 12459
Somatomedins: 271
somatomedin B: 9
Peptides: 82426
Intercellular Signaling Peptides and Proteins: 29768
Insulin-Like Peptides: 7371
Somatomedins: 271
somatomedin B: 9
Biological Factors: 2472
Intercellular Signaling Peptides and Proteins: 29768
Insulin-Like Peptides: 7371
Somatomedins: 271
somatomedin B: 9
Experts
1.
Zhou, Aiwu
: 1 article (07/2007)
2.
Bollen, Mathieu
: 1 article (04/2003)
3.
Ceulemans, Hugo
: 1 article (04/2003)
4.
Gijsbers, Rik
: 1 article (04/2003)
Related Diseases
1.
Major Depressive Disorder (Major Depressive Disorders)
11/01/1988 - "
Immunoreactive somatomedin B is increased in serum in patients with major depressive disorder.
"
11/01/1988 - "
Serum levels of immunoreactive somatomedin B (RIA-B) were investigated in patients with major depressive disorder both in the acute state and during remission at 8 h and 22 h and at 22 h after the dexamethasone suppression test.
"
2.
Acromegaly
10/01/1979 - "
Somatomedin B levels were significantly elevated in untreated acromegaly and in Turner's syndrome compared with the control group; they decreased following treatment of acromegaly.
"
10/01/1979 - "
Immunoreactive somatomedin B in acromegaly and in Turner's syndrome.
"
10/01/1979 - "
Serum somatomedin B was measured by radioimmunoassay in forty-seven normal subjects, twenty-nine patients with acromegaly before and twenty-four after treatment, and eighteen patients with Turner's syndrome.
"
10/01/1980 - "
Radioimmunoassayable serum somatomedin B in normal subjects and in patients with acromegaly and pituitary dwarfism: effects of human growth hormone therapy.
"
10/01/1979 - "
No correlation between growth hormone and somatomedin B in acromegaly was detected; however, somatomedin B appeared to be related to the insulin response during the oral glucose tolerance test.
"
3.
Weight Gain
10/01/1981 - "
Human growth hormone (hGH) caused dose-related increases in the width of the tibial epiphyseal cartilage and obvious weight gain, whereas only at 640 micrograms/week did Somatomedin B have a barely significant effect on these two parameters.
"
4.
Turner Syndrome (Turner's Syndrome)
10/01/1979 - "
The reason for the raised somatomedin B levels in Turner's syndrome remains at present unknown.
"
10/01/1979 - "
Somatomedin B levels were significantly elevated in untreated acromegaly and in Turner's syndrome compared with the control group; they decreased following treatment of acromegaly.
"
10/01/1979 - "
Immunoreactive somatomedin B in acromegaly and in Turner's syndrome.
"
10/01/1979 - "
Serum somatomedin B was measured by radioimmunoassay in forty-seven normal subjects, twenty-nine patients with acromegaly before and twenty-four after treatment, and eighteen patients with Turner's syndrome.
"
10/01/1979 - "
In Turner's syndrome, no relationship between somatomedin B and insulin production, urinary oestrogen excretion, growth hormone secretion, gonadotrophin levels, age or height was found.
"
5.
Neoplasms (Cancer)
07/01/2007 - "
The N-terminal somatomedin B domain (SMB) of vitronectin binds PAI-1 and the urokinase receptor with high affinity and regulates tumor cell adhesion and migration.
"
Related Drugs and Biologics
1.
Dexamethasone (Maxidex)
2.
Human Growth Hormone (Saizen)
3.
Vitronectin
4.
Plasminogen Activator Inhibitor 1
5.
Urokinase-Type Plasminogen Activator (Urokinase)
6.
Growth Hormone (Somatotropin)
7.
Insulin Receptor
8.
Insulin (Novolin)
9.
Glucose (Dextrose)
10.
Insulin-Like Peptides
Related Therapies and Procedures
1.
Therapeutics
2.
Aftercare (After-Treatment)