HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

reynosin

sesquiterpene derivative of costunolide

Also Known As:

Naphtho(1,2-b)furan-2(3H)-one, decahydro-6-hydroxy-5a-methyl-3,9-bis(methylene)-, (3aS-(3aalpha,5abeta,6beta,9aalpha,9bbeta))-

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - reynosin: 3

Experts

1.	Ham, Ahrom: 1 article (08/2013)
2.	Kim, Dong-Woo: 1 article (08/2013)
3.	Kim, Kyeong Ho: 1 article (08/2013)
4.	Lee, Sung-Jin: 1 article (08/2013)
5.	Mar, Woongchon: 1 article (08/2013)
6.	Oh, Ki-Bong: 1 article (08/2013)
7.	Shin, Jongheon: 1 article (08/2013)
8.	Bermejo, Jaime: 1 article (12/2003)
9.	Eiroa, José Luis: 1 article (12/2003)
10.	Estévez, Francisco: 1 article (12/2003)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 08/02/2013 - "Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson's disease: Reciprocal up-regulation of E6-AP and down-regulation of α-synuclein." 08/02/2013 - "Usi"ng flow cytometry and western blot analysis, we determined that reynosin significantly protected both against cell death from dopamine-induced toxicity in human neuroblastoma SH-SY5Y cells and against the loss of tyrosine hydroxylase (TH)-positive cells in 6-hydroxydopamine (6-OHDA)-lesioned rats (a rodent Parkinson's disease model system). " 08/02/2013 - "The aim of this study was to assess the effects of the sesquiterpene lactone reynosin on dopamine (DA)-induced neuronal toxicity and regulation of E6-associated protein and α-synuclein proteins in both in vitro and in vivo models of Parkinson's disease. "
2.	Myeloid Leukemia (Leukemia, Myelocytic) 12/15/2003 - "This paper studies the cytotoxic effect induced by four known natural sesquiterpene lactones (tatridin A, tamirin, reynosin, ineupatorolide A) and one synthetic derivative (tatridin A diacetate) on the myeloid leukemia cell lines HL-60 and U937. "
3.	Colorectal Neoplasms (Colorectal Cancer) 10/01/1996 - "praeteritum: 1 alpha, 6 alpha -dihydroxyisocostic acid methyl ester (2), 1 alpha-hydroxy-1-deoxoarglanine (3), douglanin (5), santamarin (6), reynosin (7), 1-epitatridin B (8), ludovicin A (10), armexin (12), armefolin (13), armexifolin (14), and 3 alpha-hydroxyreynosin (15) were tested against the human lung carcinoma cell line GLC4 and the colorectal cancer cell line COLO 320 as well as against the bacteria Bacillus subtilis, Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus, beta-hemolytic Streptococcus, and the yeast Candida albicans. "
4.	Neuroblastoma 08/02/2013 - "Usi"ng flow cytometry and western blot analysis, we determined that reynosin significantly protected both against cell death from dopamine-induced toxicity in human neuroblastoma SH-SY5Y cells and against the loss of tyrosine hydroxylase (TH)-positive cells in 6-hydroxydopamine (6-OHDA)-lesioned rats (a rodent Parkinson's disease model system). "
5.	Carcinoma (Carcinomatosis) 10/01/1996 - "praeteritum: 1 alpha, 6 alpha -dihydroxyisocostic acid methyl ester (2), 1 alpha-hydroxy-1-deoxoarglanine (3), douglanin (5), santamarin (6), reynosin (7), 1-epitatridin B (8), ludovicin A (10), armexin (12), armefolin (13), armexifolin (14), and 3 alpha-hydroxyreynosin (15) were tested against the human lung carcinoma cell line GLC4 and the colorectal cancer cell line COLO 320 as well as against the bacteria Bacillus subtilis, Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus, beta-hemolytic Streptococcus, and the yeast Candida albicans. "

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	Synucleins
4.	Proteins (Proteins, Gene)
5.	Dopamine (Intropin)
6.	Oxidopamine (6 Hydroxydopamine)
7.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
8.	Esters
9.	Acids
10.	antineoplaston A10 (A 10)