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7-dehydrocholesterol

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RN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3)

Also Known As:

7,8-didehydrocholesterol; 7-DHC; 7-dehydrocholesterol, (3alpha)-isomer; 7-dehydrocholesterol, (3beta,10alpha)-isomer; 7-dehydrocholesterol, (3beta,9beta)-isomer; 7-dehydrocholesterol, (3beta,9beta,10alpha)-isomer; cholesta-5,7-dien-3 beta-ol; provitamin D(3)

Networked: 117 relevant articles (3 outcomes, 5 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Xu, Libin: 11 articles (06/2015 - 02/2010)
2.	Porter, Ned A: 11 articles (06/2015 - 02/2010)
3.	Korade, Zeljka: 7 articles (06/2015 - 02/2010)
4.	Fliesler, Steven J: 7 articles (06/2012 - 02/2004)
5.	Steiner, Robert D: 6 articles (10/2014 - 10/2002)
6.	Tint, G S: 5 articles (02/2002 - 02/2000)
7.	Salen, G: 5 articles (02/2002 - 02/2000)
8.	Merkens, Louise S: 4 articles (10/2014 - 06/2009)
9.	Liu, Wei: 4 articles (02/2014 - 06/2011)
10.	Connor, William E: 4 articles (09/2012 - 10/2002)

Related Diseases

1.	Acne Vulgaris 01/01/2012 - "The combination of nicotinamide, retinol, and 7-dehydrocholesterol appears to be effective for acne treatment from both clinical and molecular standpoints." 01/01/2012 - "Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study." 01/01/2012 - "In this pilot study we investigated the changes in gene expression of extracellular MMPs, the tissue inhibitors of metalloproteinases, and proinflammatory molecules after 45 days of topical application of a combination product containing nicotinamide, retinol, and 7-dehydrocholesterol in 16 patients with inflammatory acne on their back. "
2.	Hepatocellular Carcinoma (Hepatoma) 07/02/2001 - "We show that AmB selectively interacts with 7-DHC which, according to a recent hypothesis proposed in the literature, has been identified in connexion with a therapeutic strategy against hepatocellular carcinomas. " 05/01/1999 - "We suggest: (1) using a selective accumulation of 7-dehydrocholesterol in hepatoma plasma membranes to increase the sensitivity of hepatoma cells to polyene antibiotics (amphotericin B, nystatin), because polyene antibiotics have higher affinity to 7-dehydrocholesterol compared to cholesterol; (2) using a selective accumulation of lanosterol in hepatoma cells to increase the sensitivity of hepatoma cells to different antitumor agents, because lanosterol is much less effective in supporting vital cell functions (including barrier properties of natural membranes) compared to cholesterol."
3.	Seizures (Seizure) 11/01/2004 - "We tested the hypothesis that seizures seen with AY are due to significant reduction in brain cholesterol and/or elevated brain 7-dehydrocholesterol by assessing whether three other cholesterol synthesis inhibitors mimic AY seizures in rats. " 11/01/2004 - "Lovastatin, with or without concurrent AY, mimicked AY seizures but reduced brain cholesterol by <10% and did not significantly change brain 7-dehydrocholesterol. "
4.	Smith-Lemli-Opitz Syndrome 02/01/2014 - "A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome." 04/01/2013 - "Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ(7)-reductase (DHCR7). " 03/01/2014 - "These 7-DHC metabolites were detected in serum of a patient with Smith-Lemli-Opitz syndrome. " 09/01/2013 - "Screening for Smith-Lemli-Opitz Syndrome (SLOS) using elevated 7-dehydrocholesterol (7DHC) as a marker is sensitive, but not always specific. " 01/01/2013 - "7-Dehydrocholesterol (7-DHC) accumulates in tissues and fluids of patients with Smith-Lemli-Opitz syndrome (SLOS), which is caused by mutations in the gene encoding 3β-hydroxysterol-Δ(7)-reductase (DHCR7). "
5.	Chondrodysplasia Punctata (Stippled Epiphyses) 02/24/2010 - "We propose that the high reactivity of 7-DHC and the oxysterols generated from its peroxidation may play important roles in the pathogenesis of Smith-Lemli-Opitz syndrome, X-linked dominant chondrodysplasia punctata, and cerebrotendinous xanthomatosis, all of these being metabolic disorders characterized by an elevated level of 7-DHC." 03/01/2008 - "In this study, we demonstrate abnormal accumulation of sterol precursors of cholesterol in membrane lipid rafts (detergent resistance membranes) prepared from liver tissues of these 2 infants: 8-dehydrocholesterol and 7-dehydrocholesterol in lipid rafts of the infant with Smith-Lemli-Opitz syndrome and cholest-8(9)-ene-3beta-ol in lipid rafts of the infant with X-linked dominant chondrodysplasia punctata. "

Related Drugs and Biologics

1.	Cholesterol
2.	Vitamin A (Retinol)
3.	Niacinamide (Nicotinamide)
4.	Lanosterol
5.	Nystatin (Mycostatin)
6.	Antineoplastic Agents (Antineoplastics)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Amphotericin B (Amphotericin)
9.	tebufenozide (Mimic)
10.	7-dehydrocholesterol reductase