7-dehydrocholesterol

RN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3)

Also Known As:

7,8-didehydrocholesterol; 7-DHC; 7-dehydrocholesterol, (3alpha)-isomer; 7-dehydrocholesterol, (3beta,10alpha)-isomer; 7-dehydrocholesterol, (3beta,9beta)-isomer; 7-dehydrocholesterol, (3beta,9beta,10alpha)-isomer; cholesta-5,7-dien-3 beta-ol; provitamin D(3)

Networked: 171 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Porter, Ned A: 21 articles (01/2021 - 02/2010)
2.	Xu, Libin: 18 articles (02/2021 - 02/2010)
3.	Korade, Zeljka: 14 articles (01/2021 - 02/2010)
4.	Fliesler, Steven J: 11 articles (02/2021 - 02/2004)
5.	Steiner, Robert D: 7 articles (10/2014 - 10/2002)
6.	Tallman, Keri A: 6 articles (01/2021 - 09/2011)
7.	Liu, Wei: 6 articles (01/2017 - 06/2011)
8.	Mirnics, Károly: 5 articles (01/2021 - 02/2014)
9.	Porter, Forbes D: 5 articles (01/2017 - 04/2010)
10.	Salen, G: 5 articles (02/2002 - 02/2000)

Related Diseases

1.	Acne Vulgaris 01/01/2012 - "The combination of nicotinamide, retinol, and 7-dehydrocholesterol appears to be effective for acne treatment from both clinical and molecular standpoints." 01/01/2012 - "Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study." 01/01/2012 - "In this pilot study we investigated the changes in gene expression of extracellular MMPs, the tissue inhibitors of metalloproteinases, and proinflammatory molecules after 45 days of topical application of a combination product containing nicotinamide, retinol, and 7-dehydrocholesterol in 16 patients with inflammatory acne on their back. "
2.	Hepatocellular Carcinoma (Hepatoma) 07/02/2001 - "We show that AmB selectively interacts with 7-DHC which, according to a recent hypothesis proposed in the literature, has been identified in connexion with a therapeutic strategy against hepatocellular carcinomas. " 12/01/2023 - "Previously, we reported that ergosterol increases 7-dehydrocholesterol, decreases cholesterol levels by competitive effect of DHCR7, and reduces DHCR7 mRNA and protein levels in human HepG2 hepatoma cells. " 05/01/1999 - "We suggest: (1) using a selective accumulation of 7-dehydrocholesterol in hepatoma plasma membranes to increase the sensitivity of hepatoma cells to polyene antibiotics (amphotericin B, nystatin), because polyene antibiotics have higher affinity to 7-dehydrocholesterol compared to cholesterol; (2) using a selective accumulation of lanosterol in hepatoma cells to increase the sensitivity of hepatoma cells to different antitumor agents, because lanosterol is much less effective in supporting vital cell functions (including barrier properties of natural membranes) compared to cholesterol."
3.	Seizures (Absence Seizure) 11/01/2004 - "We tested the hypothesis that seizures seen with AY are due to significant reduction in brain cholesterol and/or elevated brain 7-dehydrocholesterol by assessing whether three other cholesterol synthesis inhibitors mimic AY seizures in rats. " 11/01/2004 - "Lovastatin, with or without concurrent AY, mimicked AY seizures but reduced brain cholesterol by <10% and did not significantly change brain 7-dehydrocholesterol. "
4.	Smith-Lemli-Opitz Syndrome 02/01/2014 - "A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome." 07/01/2021 - "Voltammetry of 7-dehydrocholesterol as a new and useful tool for Smith-Lemli-Opitz syndrome diagnosis." 12/01/2017 - "This increase in 7-DHC is probably associated with the painful and itchy photosensitivity reported by the majority of patients with Smith-Lemli-Opitz syndrome. " 01/01/2016 - "Increased levels of 7-DHC are associated with Smith-Lemli-Opitz syndrome (SLOS), a human condition that results from a mutation in the gene that encodes DHCR7. " 03/01/2014 - "These 7-DHC metabolites were detected in serum of a patient with Smith-Lemli-Opitz syndrome. "
5.	Melanoma (Melanoma, Malignant) 12/01/2020 - "Therefore, the present study aimed to elucidate the mechanisms of the inhibitory effect of 7-DHC in melanoma cells via analyzing the proliferation, migration, apoptosis, cell cycle and transcriptional sequencing of melanoma cells treated with 7-DHC, as well as constructing a gene signature according to public data of patients with melanoma. " 05/01/2014 - "In this study we evaluated the effects on melanoma cell lines of 7-DHC as such and for this aim we used much care to minimize 7-DHC modifications. " 12/01/2020 - "These findings highlight the potential application of 7-DHC for the treatment of melanoma in the future." 12/01/2020 - "Overall, the present results demonstrated that 7-DHC suppressed melanoma cell proliferation and invasion via the Akt1/NF-ĸB signaling pathway, and 7-DHC key target genes were negatively associated with the prognosis. " 12/01/2020 - "Finally, by intersecting downregulated genes by 7-DHC treatment and upregulated genes in patients with melanoma, a 7-DHC gene signature was identified, which was negatively associated with the prognosis. "

Related Drugs and Biologics

1.	Cholesterol
2.	Vitamin A (Retinol)
3.	Niacinamide (Nicotinamide)
4.	Lanosterol
5.	Nystatin (Mycostatin)
6.	Antineoplastic Agents (Antineoplastics)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Amphotericin B (Amphotericin)
9.	Sterols
10.	7-dehydrocholesterol reductase

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)