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indole-3-acetonitrile

occurs in edible cruciferous vegetables

Also Known As:

1H-indole-3-acetonitrile

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - indole-3-acetonitrile: 4

Experts

1.	Amaro, Filipa: 1 article (01/2019)
2.	Duarte, Diana: 1 article (01/2019)
3.	Fresco, Paula: 1 article (01/2019)
4.	Gonçalves, Jorge: 1 article (01/2019)
5.	Oliveira, José C: 1 article (01/2019)
6.	Reguengo, Henrique: 1 article (01/2019)
7.	Silva, Dany: 1 article (01/2019)
8.	Silva, Isabel: 1 article (01/2019)
9.	Vale, Nuno: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1991 - "These results indicate that nitrosated chloroindoles and nitrosated indole-3-acetonitrile should be considered as mutagens and agents with potential tumor-promoting capacity." 05/01/1978 - "Indole-3-carbinol when added to the diet for 8 days prior to challenge with 7,12-dimethylbenz(a)anthracene inhibited mammary tumor formation, whereas indole-3-acetonitrile did not. " 05/01/1978 - "intubation 20 hr prior to 7,12-dimethylbenz(a)anthracene administration, indole-3-carbinol and 3,3'-diindolylmethane had an inhibitory effect on mammary tumor formation, but indole-3-acetonitrile was inactive. " 05/01/1978 - "Indole-3-carbinol, 3,3'-diindolylmethane, and indole-3-acetonitrile, three indoles occurring in edible cruciferous vegetables, have been studied for their effects on 7,12-dimethylbenz(a)anthracene-induced mammary tumor formation in female Sprague-Dawley rats and on benzo(a)pyrene-induced neoplasia of the forestomach in female ICR/Ha mice. "
2.	Melanoma (Melanoma, Malignant) 01/01/2019 - "Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite."
3.	Infections 12/01/2022 - "Further, we found that 1-methylindole, indene, 2,3-benzofuran, thianaphthene, indole-3-acetonitrile, methyl indole-3-carboxylate, 3-methylindole, and indole-2-carboxaldehyde exhibited a significant protective effect on brine shrimp larvae against V. campbellii infection, resulting in survival rates of challenged brine shrimp above 80%. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite."

Related Drugs and Biologics

1.	9,10-Dimethyl-1,2-benzanthracene
2.	Tryptophan (L-Tryptophan)
3.	Skatole (3 Methylindole)
4.	Mutagens
5.	Indoles
6.	Carbidopa (Lodosyn)
7.	Benzo(a)pyrene
8.	benzofuran
9.	indene
10.	benzothiophene