Thomsen-Friedenreich antigen

do not confuse with T antigens, which are viral

Also Known As:

2-acetamido-2-deoxy-3-O-(beta--galactopyranosyl)-D-galactose; 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-beta-D-galactopyranose; Gal(beta-3)GalNAc; Gal(beta1-3)GalNAc; Gal-GalNAc; Galbeta(1-3)GalNAc; T antigen, mucin-type; T antigen, mucin-type carbohydrate; T mucin-type carbohydrate antigen; T-antigen, erythrocyte; T-crypt antigen; TF-antigen; beta-D-Gal(1-3)alpha-D-GalNAc; beta-D-galactosyl(1-3)-N-acetyl-D-galactosamine; beta-galactosyl(1-3)-N-acetylgalactosamine; erythrocyte T antigen; galactose beta1-3-nacetyl-galactosamine alpha-O-Ser-Thr; D-Galactose, 2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-

Networked: 354 relevant articles (3 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biomarkers: 240291
  - Tumor Biomarkers: 15272
    - Carbohydrate Tumor-Associated Antigens: 355
      - Thomsen-Friedenreich antigen: 354
- Antigens: 143924
  - Epitopes: 19548
    - Carbohydrate Tumor-Associated Antigens: 355
      - Thomsen-Friedenreich antigen: 354
  - Neoplasm Antigens: 6217
    - Carbohydrate Tumor-Associated Antigens: 355
      - Thomsen-Friedenreich antigen: 354

Experts

1.	Sakuma, Shinji: 10 articles (03/2019 - 10/2008)
2.	Kurtenkov, Oleg: 9 articles (01/2020 - 08/2002)
3.	Glinsky, Vladislav V: 9 articles (09/2017 - 02/2003)
4.	Jeschke, Udo: 8 articles (02/2020 - 06/2005)
5.	Klaamas, Kersti: 8 articles (01/2018 - 08/2002)
6.	Glinskii, Olga V: 8 articles (09/2017 - 07/2003)
7.	Pham, Wellington: 7 articles (03/2019 - 11/2011)
8.	Rittenhouse-Olson, Kate: 7 articles (09/2017 - 08/2002)
9.	Karsten, Uwe: 7 articles (05/2013 - 06/2005)
10.	Kumagai, Hironori: 6 articles (03/2019 - 11/2011)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1998 - "To study the immunohistochemical expression of the Thomsen-Friedenreich antigen (T) and its precursor, Tn, in the skin in various cancers. " 01/01/2020 - "The Thomsen-Friedenreich (TF) antigen is expressed in a majority of human tumors due to aberrant glycosylation in cancer cells. " 11/25/2018 - "What is most noteworthy regarding the probe is its ability to visualize tumor margins defined by epithelial TF antigen expression. " 04/25/2018 - "Abnormal expression of sialylated Thomsen-Friedenreich antigen (Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr, sialyl-T) has a strong relationship with various types of human cancers and many other diseases. " 07/01/2015 - "One example of such changes is demasking of the otherwise hidden core-1 structure, also known as Thomsen-Friedenreich antigen, which is a highly tumor-specific glycotope and potentially a cancer stem cell marker. "
2.	Colonic Neoplasms (Colon Cancer) 07/01/2001 - "Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44." 03/01/2018 - "To determine whether the structural and functional diversities of naturally occurring antibodies to the Thomsen - Friedenreich (TF) antigen may be of diagnostic and prognostic value in colon cancer. " 05/01/2001 - "Increasing the intra-Golgi pH of cultured LS174T goblet-differentiated cells mimics the decreased mucin sulfation and increased Thomsen-Friedenreich antigen (Gal beta1-3GalNac alpha-) expression seen in colon cancer." 02/01/2001 - "Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins." 11/04/1997 - "Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta1-3 N-acetyl-galactosamine)."
3.	Amebiasis (Amoebiasis) 12/01/2016 - "Entamoeba histolytica: Overexpression of the gal/galnac lectin, ehcp2 and ehcp5 genes in an in vivo model of amebiasis." 01/17/2011 - "Amebiasis in the murine model can be prevented by vaccination with the Gal/GalNAc lectin through a T cell-dependent mechanism. " 03/01/2004 - "Evaluation of recombinant fragments of Entamoeba histolytica Gal/GalNAc lectin intermediate subunit for serodiagnosis of amebiasis." 11/01/2000 - "Recent developments in amoebiasis:the Gal/GalNAc lectins of Entamoeba histolytica and Entamoeba dispar." 02/01/1996 - "Amebiasis and the Entamoeba histolytica Gal/GalNAc lectin: from lab bench to bedside."
4.	Urinary Bladder Neoplasms (Bladder Cancer) 02/01/1988 - "[Study of the Thomsen-Friedenreich antigen in bladder tumors]." 04/01/1987 - "[The study of Thomsen-Friedenreich antigen and prognosis of the patients with bladder tumor]." 03/01/1985 - "[The study on Thomsen-Friedenreich antigen in bladder tumor]." 03/01/1987 - "The results do not support previous observations on the prognostic value of Thomsen-Friedenreich antigen determination in superficial bladder cancer." 01/01/1985 - "Thomsen-Friedenreich antigen in bladder tumors as detected by specific antibody: a possible marker of recurrence."
5.	Carcinoma (Carcinomatosis) 10/19/2022 - "The Thomsen-Friedenreich antigen (TF-Ag-α) is found on ~85% of human carcinomas but is cryptic on normal tissue. " 09/05/2018 - "The TF antigen, detected by simple antibody-based assays, is highly specific for carcinoma being undetectable in gastric healthy and premalignant epithelia. " 11/01/2006 - "Thomsen-Friedenreich antigen (TF-Ag) is expressed in many carcinomas, including those of the breast, colon, bladder, and prostate. " 02/01/2003 - "These bound to TF antigen on carcinoma cells but were of low affinity and solubility. " 11/01/2001 - "Correlation between the sialylation of cell surface Thomsen-Friedenreich antigen and the metastatic potential of colon carcinoma cells in a mouse model."

Related Drugs and Biologics

1.	Lectins
2.	Antigens
3.	Mucins
4.	Biomarkers (Surrogate Marker)
5.	Tumor Biomarkers (Tumor Markers)
6.	Immune Sera (Antisera)
7.	Galectin 3 (LGALS3)
8.	Peptides (Polypeptides)
9.	Isoantigens (Alloantigen)
10.	Tumor Viral Antigens (Large T Antigen)

Related Therapies and Procedures

1.	Therapeutics
2.	Secondary Prevention
3.	Chemoprevention
4.	Drug Therapy (Chemotherapy)
5.	Nanospheres