o,p'-DDT

RN given refers to cpd without isomeric designation.

Also Known As:

1,1,1-trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethane; 2,4'-DDT; benzene, 1-chloro-2-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)-, (R)-; o,p'-DDT, (-)-; o,p'-DDT, (R)-isomer; o,p'-dichlorodiphenyltrichloroethane; o,p-DDT

Networked: 58 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - DDT: 1636
        o,p'-DDT: 58

Experts

1.	Cirillo, Piera M: 6 articles (01/2021 - 01/2013)
2.	Cohn, Barbara A: 6 articles (01/2021 - 01/2013)
3.	Eskenazi, Brenda: 5 articles (01/2019 - 04/2006)
4.	Krigbaum, Nickilou Y: 4 articles (01/2021 - 08/2015)
5.	Bradman, Asa: 4 articles (01/2016 - 04/2006)
6.	Jeong, Hye Gwang: 3 articles (10/2021 - 11/2002)
7.	Bornman, Riana: 3 articles (01/2019 - 12/2015)
8.	Chevrier, Jonathan: 3 articles (01/2019 - 12/2015)
9.	Crause, Madelein: 3 articles (01/2019 - 12/2015)
10.	Obida, Muvhulawa: 3 articles (01/2019 - 12/2015)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/18/2015 - "Herein, we conducted a systematic study of the effect of o,p'-DDT on stereoselective breast tumor cell progression in a widely used in vitro breast tumor cell model, MCF-7 cells. " 01/01/2020 - "We focused our analyses on o,p'-DDT exposure given our previous report of a positive association between intrauterine o,p'-DDT exposure and daughter's breast cancer (BC) risk. " 08/01/2015 - "Maternal o,p'-DDT predicted daughters' breast cancer (odds ratio fourth quartile vs first = 3.7, 95% confidence interval 1.5-9.0). " 09/01/2012 - "The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells." 01/01/2009 - "Enantioselective estrogenicity of o,p'-dichlorodiphenyltrichloroethane in the MCF-7 human breast carcinoma cell line."
2.	Neoplasms (Cancer) 06/10/2021 - "Adults were identified as the most susceptible population in terms of cancer risks, with o,p'-DDT being the primary contributor of ILCRs. " 10/16/2008 - "We have previously reported that o, p'-DDT elicits primarily PXR/CAR-mediated activity, rather than ER-mediated hepatic responses, and suggested that CAR-mediated effects, as opposed to ER-mediated effects, may be more important in tumor promotion in the rat liver. " 03/01/1977 - "Using Scatchard and Linweaver-Burk plot analyses, the inhibition by o,p'DDT of 3H-E2 binding to mammary tumors EBP appears to result from competition for the 8S moiety binding sites and not from deactivation of the binding sites. " 03/01/1977 - "o,p'DDT inhibited the binding of 3H-E2 to EBP in both breast and uterine tumors. " 07/01/2005 - "In the present study, we have investigated the effect of o,p'-DDT on mammary gland cell proliferation and chromosomal alterations, in a rat mammary cancer model (commonly used to study human cancer), to gain insights into its potential role in the development of breast cancer. "
3.	Endometrial Neoplasms (Endometrial Cancer) 04/01/2009 - "The aim of this study was to examine global gene expression profiles in estrogen receptor (ER)-proficient Ishikawa plus and ER-deficient Ishikawa minus endometrial cancer cells treated with selected well-known EACs (diethylstilbestrol, genistein, zearalenone, resveratrol, bisphenol A and o,p'-DDT). "
4.	Pheochromocytoma 02/03/2003 - "In this study, therefore, we observed the effects of p,p'-DDT, o,p'-DDT and its major metabolite p,p'-DDE on the differentiation and survival of PC12 pheochromocytoma cells. "
5.	Herpes Zoster 06/01/2000 - "This study examines the responses of eggshell zona radiata proteins (Zrp) and vitellogenin (Vtg) to five environmental pollutants; 4-nonylphenol (NP) and o,p'-DDT [both at 25 mg/kg], lindane (gamma-HCH) [10 mg/kg], a technical PCB mixture (Aroclor 1254; A1254) and bisphenol A (BPA) [both at 5 mg/kg] in juvenile Atlantic salmon (Salmo salar). "

Related Drugs and Biologics

1.	DDT
2.	bisphenol A
3.	Proteins (Proteins, Gene)
4.	Dichlorodiphenyl Dichloroethylene (DDE)
5.	o,p'-DDT
6.	beta-hexachlorocyclohexane
7.	Estrogen Receptors
8.	Estrogens (Estrogen)
9.	Estradiol (Delestrogen)
10.	Genistein

Related Therapies and Procedures

1.	Injections
2.	Aftercare (After-Treatment)