cobra venom factor

01/01/1990 - "By decomplementation with cobra venom factor, on the other hand, pneumococci were not eliminated completely from the lungs during the early stage of infection and afterward proliferated extensively. "
01/01/2014 - "Decreases in hCR1 were completely dependent on C3 expression, as mice treated with cobra venom factor (which consumes and depletes C3) retained hCR1 on erythrocytes during C3 depletion through day 7; erythrocyte hCR1 decreases were observed only when C3 levels recovered on day 9. B-cell-deficient mice exhibit a marked increase in survival following infection with P. "
10/01/1992 - "The effect of cobra venom factor (CoVF) treatment was examined to clarify the mechanism of resistance of mice to Clostridium chauvoei infection. "
10/01/1992 - "Effect of cobra venom factor on experimental infection of mice against Clostridium chauvoei."
01/01/1988 - "Depletion of C3 by cobra venom factor for a period of 14 days affected neither the host's susceptibility to infection nor the humoral response. "

01/01/1986 - "Experimental studies of rats have provided significant evidence that intravascular complement activation after i.v. injection of cobra venom factor (CVF) or thermal injury of skin can result in acute lung injury. "
05/01/1986 - "We have now employed an ex vivo model of perfused rat lung which allows a more detailed examination of the role of circulating blood elements and pulmonary vascular pressure changes in the acute lung injury that occurs following cobra venom factor (CVF)-induced complement activation. "
01/01/1983 - "Intravascular complement activation in rats following thermal injury or vascular infusion of cobra venom factor results in acute lung injury as determined morphologically and measured by increases in lung vascular permeability. "
04/01/1985 - "Acute lung injury has been produced in mice by the intravenous injection of cobra venom factor. "
08/01/2013 - "Pre-treatment with Cobra venom factor alleviates acute lung injury induced by intestinal ischemia-reperfusion in rats."

04/01/1984 - "An experimental Streptococcus pneumoniae pneumonia was used to study the influence of continuous versus intermittent administration of penicillin G on therapeutic efficacy in normal rats and in rats whose phagocytic capacities were impaired by decomplementation with cobra venom factor. "
08/01/1982 - "The development of chronic pulmonary inflammation by aerosol challenge with antigen was suppresed with cobra venom factor. "
08/01/1980 - "Depletion of serum complement with cobra venom factor before infection with type 25 pneumococci resulted in severe bacteremic pneumonia in the rabbit, but immunization before complement depletion allowed animals to clear type 25 pneumococci from the blood and lungs within 24 hr. Thus, opsonization is required for efficient clearance of pneumococci from the lung, and in the nonimmune animal, complement is also required for clearance."
01/01/1993 - "The present study has shown that circulating complement depletion by cobra venom factor resulted in the reduction in severity of immune-complex-mediated pulmonary inflammation. "

02/01/1998 - "In contrast, UK-74,505 had no effect on cobra venom factor-induced lung injury and neutrophil sequestration. "
11/15/1996 - "Cobra venom factor (CVF) induces lung injury through oxidant- and neutrophil-dependent mechanisms. "
06/15/1993 - "In the model of rapidly developing lung injury due to systemic activation of C after infusion of cobra venom factor, DM/C7 was not protective. "
10/01/1989 - "Lung injury caused by cobra venom factor is reduced in rats raised on an essential fatty acid-deficient diet."
10/01/1987 - "Activation of C5 by cobra venom factor is required in neutrophil-mediated lung injury in the rat."

02/01/1980 - "Cobra venom factor completely eliminated inflammatory responses, indicating that the complement system is a trigger for this type of ocular inflammation. "
03/01/2006 - "The importance of complement to the development of EAAU was studied by comparing the course of intraocular inflammation in normal Lewis rats (complement-sufficient) with cobra venom factor-treated rats (complement-depleted). "
01/01/1991 - "Increased complement deposition was not evident along the tubular basement membranes; moreover, C3 depletion with cobra venom factor failed to attenuate the interstitial inflammation. "
01/01/1986 - "To evaluate the role of the complement system in skin inflammation accompanying leukocyte infiltration induced by UVB irradiation, the response of guinea pigs decomplemented with cobra venom factor was compared with that in saline-treated animals. "
06/01/1985 - "Complement depletion by cobra venom factor did not affect the histamine release nor the increased vascular permeability in the inflammation of this type. "