4-epianhydrotetracycline (anhydrotetracycline)

impurity in pahrmaceutical preparations of tetracycline; RN refers to (4S-(4alpha,4aalpha,12aalpha))-isomer

Also Known As:

anhydrotetracycline; 5a,6-anhydrotetracycline; 5a,6-anhydrotetracycline hydrochloride, (4R-(4alpha,4abeta,12abeta))-isomer; 5a,6-anhydrotetracycline hydrochloride, (4S-(4alpha,4aalpha,12aalpha))-isomer; 5a,6-anhydrotetracycline, (4R-(4alpha,4abeta,12abeta))-isomer; anhydro-4-epitetracycline

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Flores, Amando: 2 articles (01/2019 - 01/2016)
2.	Santero, Eduardo: 2 articles (01/2019 - 01/2016)
3.	Besra, Gurdyal S: 1 article (10/2020)
4.	Burke, Christopher: 1 article (10/2020)
5.	Cox, Jonathan A G: 1 article (10/2020)
6.	Esquivias, Jorge: 1 article (10/2020)
7.	Gonzalez Del Rio, Ruben: 1 article (10/2020)
8.	Jankute, Monika: 1 article (10/2020)
9.	Lelièvre, Joël: 1 article (10/2020)
10.	Li, Xiaojun: 1 article (10/2020)

Related Diseases

1.	Tuberculosis (Tuberculoses) 01/01/2012 - "tuberculosis conditional mutant strains (Mtb(Pptr)eccB(5) and Mtb(Pptr)eccC(5)), in which the eccB(5)-eccC(5) operon or the eccC(5) gene, respectively, were expressed under the control of an anhydrotetracycline-repressible promoter, confirmed that the repression of eccB(5)-eccC(5) genes is detrimental for growth of M. " 10/01/2009 - "tuberculosis conditional mutant in which transcription of the ESX-3 gene cluster can be downregulated by anhydrotetracycline. " 10/01/2020 - "tuberculosis H37Rv augmented with anhydrotetracycline-inducible expression of mCherry, a phenotypic screen was developed for the identification of protein synthesis inhibitors in a medium throughput screening format. " 11/20/2018 - "tuberculosis yidC under a strong anhydrotetracycline-inducible promoter results in significant induction of YidC protein. "
2.	Dehydration (Water Stress) 05/01/2010 - "Product evaluation indicates that Al(2)O(3) promotes dehydration of TTC to yield anhydrotetracycline (AHTTC), epimerization of TTC, and formation of Al-TTC complexes. " 11/01/1977 - "Through nonlinear regression analysis, rate constants for the reversible first-order epimerization of tetracycline and anhydrotetracycline and for the first-order dehydration of tetracycline and epitetracycline were obtained. "
3.	Autolysis 01/01/2019 - "Here we have used an inducible autolysis system that lyses bacteria thus releasing its content in both, liquid and solid cultures, in response to anhydrotetracycline. " 01/01/2016 - "Here we have developed an inducible autolysis system based in the lysis operon of the lambda phage that, in response to anhydrotetracycline, lysates Salmonella thus releasing its content. "
4.	Peritonitis 12/01/2006 - "Addition of anhydrotetracycline led to a 62-fold induction of GFP expression in vitro and 15-fold induction in a mouse mycobacterial peritonitis model in the presence of maximal tetR expression. "
5.	Neoplasms (Cancer) 05/01/2006 - "Therefore, we used a mouse tumor model that allows downregulation of HER-2 in tumor tissue by administration of anhydrotetracycline (ATc). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Drinking Water
3.	Tetracycline (Achromycin)
4.	Protein Synthesis Inhibitors
5.	Doxycycline (Periostat)