phospholamban

regulator for Ca transport ATPase of cardiac sarcoplasmic reticulum; becomes resistant to tryptic digestion upon phosphorylation by cAMP-dependent protein kinase; protective effect of phosphorylation is accompanied by persistence of the protein kinase-induced stimulation of Ca transport; RefSeq NM_002667 (human), NM_023129 (mouse); NM_022707 (rat)

Also Known As:

Networked: 419 relevant articles (13 outcomes, 41 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kranias, Evangelia G: 36 articles (02/2022 - 01/2002)
2.	de Boer, Rudolf A: 15 articles (10/2022 - 11/2012)
3.	van Tintelen, J Peter: 12 articles (01/2022 - 11/2012)
4.	van den Berg, Maarten P: 11 articles (10/2022 - 11/2012)
5.	Haghighi, Kobra: 11 articles (02/2022 - 03/2003)
6.	Hajjar, Roger J: 11 articles (02/2022 - 02/2002)
7.	Kranias, E G: 11 articles (02/2019 - 04/2000)
8.	van der Zwaag, Paul A: 10 articles (01/2022 - 11/2012)
9.	Asselbergs, Folkert W: 9 articles (10/2022 - 01/2014)
10.	Wilde, Arthur A M: 9 articles (10/2022 - 11/2012)

Related Diseases

1.	Heart Failure 01/01/2013 - "Furthermore, long-term expression of active inhibitor-1 via recombinant adeno-associated virus type 9 gene transfer in rats with pressure-overload induced heart failure improved function and prevented remodeling, associated with increased phosphorylation of phospholamban at Ser16 and Thr17. " 08/01/1997 - "A number of studies have suggested a decrease in SERCA2a relative to phospholamban in heart failure. " 10/20/2022 - "Phospholamban (PLN) p.Arg14del mutation carriers are at risk of developing malignant ventricular arrhythmias (VAs) and/or heart failure. " 01/01/2022 - "Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure." 01/01/2020 - "The elevated expression of phospholamban (PLB) has been observed in heart failure and cardiac remodelling, inhibiting the affinity of Ca2+ pump to Ca2+ thereby impairing heart relaxation. "
2.	Cardiomyopathies (Cardiomyopathy) 03/01/2008 - "In the present study we performed exhaustive global proteomics surveys of cardiac ventricle isolated from a mouse model of cardiomyopathy overexpressing a phospholamban mutant, R9C (PLN-R9C), and exhibiting impaired Ca2+ handling and death at 24 weeks and compared them with normal control littermates. " 06/01/2001 - "[Genetic complementation studies using genetically engineered mice have revealed the impact of phospholamban on progression of cardiomyopathy]." 09/01/2000 - "Studies with knockout and transgenic mice show that gain of inhibitory function of phospholamban alters cardiac contractility and could be a causal feature in some cardiomyopathies. " 01/31/2023 - "Phospholamban (PLN) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. " 01/01/2023 - "Arrhythmogenic Left Ventricular Cardiomyopathy Associated With a Phospholamban Gene Mutation in a Young Female: A Case Report and Literature Review."
3.	Cardiac Arrhythmias (Arrythmia) 01/01/2023 - "As proof of concept, we screened 20 AF-associated genes and identified phospholamban loss of function as a top conserved hit that shortens action potential duration and increases the incidence of arrhythmia phenotypes upon stress. " 01/01/2021 - "Prediction of ventricular arrhythmia in phospholamban p.Arg14del mutation carriers-reaching the frontiers of individual risk prediction." 04/01/2019 - "Phospholamban R14del mutation carriers and family members were identified from inherited arrhythmia clinics at 13 sites across Canada. " 01/01/2021 - "This study aims to improve risk stratification for primary prevention implantable cardioverter defibrillator (ICD) implantation by developing a new mutation-specific prediction model for malignant ventricular arrhythmia (VA) in phospholamban (PLN) p.Arg14del mutation carriers. " 10/01/2021 - "Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation."
4.	Fibrosis (Cirrhosis) 01/01/2021 - "Fibrosis was not associated with p62 accumulation in subgroup analysis of phospholamban hearts. " 01/01/2019 - "Myocardial fibrosis as an early feature in phospholamban p.Arg14del mutation carriers: phenotypic insights from cardiovascular magnetic resonance imaging." 01/01/2017 - "Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies." 01/01/2014 - "High resolution systematic digital histological quantification of cardiac fibrosis and adipose tissue in phospholamban p.Arg14del mutation associated cardiomyopathy." 09/01/2013 - "Neither myocardial fibrosis nor hypertrophy were detected in db/db, whereas titin N2B expression was increased and phosphorylation of phospholamban was reduced both being prevented by HR reduction in db/db-Iva. "
5.	Reperfusion Injury 08/01/2004 - "Phosphorylation of phospholamban in ischemia-reperfusion injury: Functional role of Thr(17) residue." 08/01/2004 - "Phosphorylation of phospholamban in ischemia-reperfusion injury: functional role of Thr17 residue." 06/01/2005 - "Role of dual-site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury." 01/01/2018 - "Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2." 01/01/2018 - "Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury."

Related Drugs and Biologics

1.	Calcium
2.	Proteins (Proteins, Gene)
3.	Adenosine Triphosphatases (ATPase)
4.	Messenger RNA (mRNA)
5.	Calcium-Transporting ATPases (Ca2+ ATPase)
6.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
7.	Protein Isoforms (Isoforms)
8.	Myosin Heavy Chains (Myosin Heavy Chain)
9.	Collagen
10.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Therapeutics
2.	Microbubbles
3.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
4.	Ovariectomy (Oophorectomy)
5.	Precision Medicine