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pentachloroethane
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Halogenated Hydrocarbons: 42
Chlorinated Hydrocarbons: 240
pentachloroethane: 3
Acyclic Hydrocarbons
Alkanes: 241
Ethane: 225
pentachloroethane: 3
Related Diseases
1.
Carcinogenesis
04/01/1983 - "
Carcinogenesis Studies of Pentachloroethane (CAS No. 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study).
"
04/01/1983 - "
A carcinogenesis bioassay of technical grade pentachloroethane (95.5% pure, with 4.2% hexachloroethane) was conducted by administering the test chemical in corn oil by gavage to groups of 50 male and 50 female F344/ N rats at doses of 75 or 150 mg/ kg body weight and to groups of 50 male and 50 female B6C3F1 mice at doses of 250 or 500 mg/ kg. (Pentachloroethane is a solvent that was used primarily as an intermediate in the manufacture of tetrachloroethylene.) Doses were administered for 103 weeks for rats and 41-103 weeks for mice.
"
2.
Hepatocellular Carcinoma (Hepatoma)
04/01/1983 - "
Technical grade pentachloroethane was carcinogenic for B6C3F1 mice, causing hepatocellular carcinomas in males and females, and adenomas in females.
"
04/01/1987 - "
Trichloroethylene (TCE), perchloroethylene (PER), and pentachloroethane (PENT) are widely used industrial chemicals that cause an increased incidence of hepatocellular carcinoma in mice and a very low incidence of renal tubular adenocarcinoma in rats.
"
3.
Polyploidy
08/12/1996 - "
Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloroethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy).
"
4.
Neoplasms (Cancer)
04/01/1983 - "
The National Toxicology Program considers that these rare tubular-cell tumors of the kidney in male rats indicate a target organ and may have been associated with the administration of pentachloroethane.
"
04/01/1983 - "
Pentachloroethane administration did not cause any increased incidences of tumors in either male or female rats.
"
5.
Chromosome Aberrations (Chromosome Abnormalities)
08/12/1996 - "
Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloroethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy).
"
Related Drugs and Biologics
1.
Tetrachloroethylene (Tetrachloroethene)
2.
Trichloroethylene (Trichloroethene)
3.
Solvents
4.
Corn Oil (Oil, Corn)
5.
chlorendic acid
6.
chlorodibromomethane
7.
1,1,1,2-tetrachloroethane
8.
bromodichloromethane
9.
hexachloroethane
10.
isophorone