isosafrole

RN given refers to cpd without isomeric designation

Also Known As:

4-propenyl-1,2-methylenedioxybenzene; 5-((1E)-1-propenyl)-1,3-benzodioxole; beta-isosafrole; isosafrol; isosafrole, (E)-isomer; 5-(1-propenyl)-1,3-benzodioxole

Networked: 11 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Allylbenzene Derivatives: 4
        Safrole: 67
        isosafrole: 11
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Benzodioxoles: 3
      - Safrole: 67
        isosafrole: 11
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzodioxoles: 3
      - Safrole: 67
        isosafrole: 11

Related Diseases

1.	Cholestasis 11/01/1994 - "In addition, sesamol, methylenedioxybenzene and isosafrole showed significant protective effects against cholestasis induced by CCl4."
2.	Neoplasms (Cancer) 01/01/1979 - "By contrast, neoplasms of the forestomach were not increased in mice receiving safrole or isosafrole. " 09/16/1985 - "The isolated human P1-450 genomic clone hybridizes to 3-methylcholanthrene-induced mRNA from monkey liver, benzanthracene and 3-methylcholanthrene-treated human mammary tumor cells (MCF-7), but not to isosafrole-treated human cells. "
3.	Necrosis 12/12/1997 - "Previously it was shown that methylenedioxybenzenes (MDBs), particularly isosafrole, were highly effective at preventing CCl4-induced liver necrosis in vivo (Z.S. " 12/12/1997 - "In the following it was shown that pretreatment of mice with isosafrole also completely prevented ferric nitrilotriacetate (FeNTA)-induced renal necrosis and lipid peroxidation, even though metabolic activation by cytochrome P450 is not involved. " 10/01/1996 - "Pretreatment with isosafrole, safrole, dihydrosafrole, and benzodioxole at dosages as low as 10 mg/kg significantly prevented the increase in plasma transaminase levels and histochemical changes associated with CCl4-induced liver necrosis, whereas piperonyl butoxide (PBO), eugenol, isoeugenol, sesamol, and curcumin did not prevent CCl4 hepatotoxicity even at 200 mg/kg. However, isosafrole was only partly hepatoprotective if administered 10 min after the toxicant. "
4.	Body Weight (Weight, Body) 03/01/1985 - "Isosafrole but not promethazine increased the liver to body weight ratio. " 07/01/1985 - "High-performance liquid chromatography of hydrolysates of the hepatic DNA of male 12-day-old B6C3F1 mice killed 9 h after a single dose (0.1 mumol/g body weight) of [2',3'-3H]-1'-hydroxysafrole showed that Adducts S-Ia, S-Ib, S-II, S-IV (identified by Phillips et al. as N6-(trans-isosafrol-3'-yl)deoxyadenosine), S-V, and S-VI were present at average levels of 3.5, 7.0, 24.4, 2.9, 1.2, and 3.6 pmol/mg DNA, respectively. "
5.	Schizophrenia (Dementia Praecox) 08/01/1984 - "Isosafrole may provide another biochemical model for schizophrenia." 08/01/1984 - "A 19-year-old man developed a schizophrenia-like psychosis after ingesting isosafrole. " 08/01/1984 - "Isosafrole and schizophrenia-like psychosis."

Related Drugs and Biologics

1.	sesamol
2.	1,3-benzodioxole
3.	Safrole (Safrol)
4.	Phenobarbital (Luminal)
5.	Isoenzymes
6.	Cytochromes
7.	Benzodioxoles
8.	Cytochrome P-450 CYP1A2 (CYP1A2)
9.	beta-Naphthoflavone
10.	Sterigmatocystin