histidyl-proline diketopiperazine

biologically active cpd to which thyrotropin-releasing hormone (TRH) is metabolized; structure; RN given refers to cpd without isomeric designation

Also Known As:

His-Pro-Dkp; cyclo(His-Pro); cyclo(histidyl-prolyl); histidyl-proline diketopiperazine, (3R-cis)-isomer; histidyl-proline diketopiperazine, (3S-cis)-isomer; histidyl-proline diketopiperazine, (3S-trans)-isomer; histidyl-proline-diketopiperazine; Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-(1H-imidazol-4-ylmethyl)-, (3S-trans)-

Networked: 42 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bellezza, Ilaria: 4 articles (01/2018 - 03/2012)
2.	Grottelli, Silvia: 4 articles (01/2018 - 03/2012)
3.	Minelli, Alba: 4 articles (01/2018 - 03/2012)
4.	Cacciatore, Ivana: 3 articles (01/2020 - 03/2012)
5.	Fornasari, Erika: 2 articles (01/2020 - 06/2014)
6.	Peirce, Matthew J: 2 articles (01/2018 - 08/2016)
7.	Song, Albert M: 2 articles (06/2017 - 11/2005)
8.	Song, Moon K: 2 articles (06/2017 - 11/2005)
9.	Yamaguchi, Dean T: 2 articles (06/2017 - 11/2005)
10.	Arslan, Mehmet Enes: 1 article (01/2020)

Related Diseases

1.	Body Weight (Weight, Body) 11/01/2005 - "Raw vegetable food containing high cyclo (his-pro) improved insulin sensitivity and body weight control." 12/01/1988 - "Although food and water intake were not decreased, body weight gain was slightly reduced in the rats treated with TRH or cyclo(His-Pro) during the 1st and 2nd week of life, whereas the mixture-treated rats showed normal weight gain. " 09/01/2009 - "Body weight reduction in rats by oral treatment with zinc plus cyclo-(His-Pro)." 11/01/2005 - "Cyclo (his-pro), controlled-energy diet, soy protein hydrolysate (SPH), and raw vegetable food (RVF) are known to improve insulin sensitivity and body weight (BW) control. "
2.	Insulin Resistance 11/01/2005 - "Raw vegetable food containing high cyclo (his-pro) improved insulin sensitivity and body weight control." 11/01/2005 - "Cyclo (his-pro), controlled-energy diet, soy protein hydrolysate (SPH), and raw vegetable food (RVF) are known to improve insulin sensitivity and body weight (BW) control. "
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2020 - "In this study, we tested Cyclo (His-Pro) isomers (cHP1-4) for their anti-Alzheimer potential using a differentiated human neuroblastoma cell line (SH-SY5Y) as an Alzheimer's disease (AD) experimental model. " 06/01/2017 - "Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment."
4.	Pancreatitis 12/01/1993 - "We have developed a convenient method combining fast protein liquid chromatography (FPLC) with sensitive radioimmunoassay (RIA) for thyrotropin-releasing hormone (TRH) to separate and identify TRH and its metabolite histidyl-proline diketopiperazine (CHP) and applied this to study inactivation of TRH by blood extracts from patients with liver cirrhosis (LC) and acute edematous pancreatitis (AP). "
5.	Pancreatic Diseases (Pancreatic Disease) 12/01/1993 - "A fast protein liquid chromatography (FPLC) method for study of thyrotropin-releasing hormone (TRH) and its metabolite histidyl-proline diketopiperazine (CHP) in human blood: degradation in liver and pancreatic diseases."

Related Drugs and Biologics

1.	Thyrotropin-Releasing Hormone (Protirelin)
2.	Proteins (Proteins, Gene)
3.	histidyl-proline diketopiperazine
4.	Ethanol (Ethyl Alcohol)
5.	Dipeptides
6.	Zinc
7.	Streptozocin (Streptozotocin)
8.	Neuropeptides
9.	Insulin (Novolin)
10.	Heme Oxygenase-1

Related Therapies and Procedures

1.	Anesthesia
2.	Oral Administration