HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

guvacine

RN given refers to parent cpd

Also Known As:

guvacine hydrobromide; guvacine hydrochloride; 1,2,5,6-tetrahydronicotinic acid

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Nicotinic Acids: 13
      - guvacine: 6
- Heterocyclic Acids
  - Nicotinic Acids: 13
    - guvacine: 6

Experts

1.	Chong, Kah Wee: 1 article (01/2022)
2.	Chua, Nathaniel Quan En: 1 article (01/2022)
3.	Cirillo, Nicola: 1 article (01/2022)
4.	Dang, Simon: 1 article (01/2022)
5.	Davis, Ashleigh: 1 article (01/2022)
6.	Prime, Stephen S: 1 article (01/2022)
7.	Zhang, Pangzhen: 1 article (01/2022)
8.	Lee, Chien-Hung: 1 article (01/2022)
9.	Osborne, Peter G: 1 article (01/2022)
10.	Pasupuleti, Ragavendra Rao: 1 article (01/2022)

Related Diseases

1.	Myoclonus (Nocturnal Myoclonus) 01/01/1996 - "Administration of guvacine (1 or 10 mg/kg, IP) or nipecotic acid (0.5 or 5 mg/kg, IP) significantly attenuated myoclonus scores of the animals. " 01/01/1996 - "In current studies, effects of GABA uptake inhibitors, guvacine hydrochloride (1,2,5,6-tetrahydro-3-pyridine carboxylic acid hydrochloride) and (+/-)-cis-4-hydroxynipecotic acid ([+/-]-cis-4-hydroxy-3-piperidine carboxylic acid), in the pathophysiology of posthypoxic myoclonus were investigated. "
2.	Mouth Neoplasms (Oral Cancer) 01/01/2022 - "Chewing of BQ is associated with oral cancers due to specific carcinogenic alkaloids (arecaidine, guvacine, guvacoline, arecoline, N-Nitrosoguvacoline) in AN. To predict the hazardous health risks of short and long-term chewing of BQ, it is crucial to identify five toxic AN alkaloids in saliva and urine of BQ chewers. " 10/01/1989 - "Because betel quid chewing has been linked to the development of oral cancer, pathobiological effects of an aqueous areca nut extract, four areca nut alkaloids (arecoline, guvacoline, guvacine, and arecaidine), and four nitrosated derivatives [N-nitrosoguvacoline, N-nitrosoguvacine, 3-(N-nitrosomethylamino)propionaldehyde and 3-(N-nitrosomethylamino)propionitrile] have been investigated using cultured human buccal epithelial cells. "
3.	Carcinogenesis 01/31/2022 - "Four major areca alkaloids-arecoline, arecaidine, guvacoline and guvacine-together with the polyphenols, were identified as being potentially involved in oral carcinogenesis. "
4.	Neurobehavioral Manifestations 04/01/2012 - "We reviewed the clinical literature data since 1980 via a PubMed search for the terms: arecoline, arecaidine, guvacine, guvacoline, betel, Areca catechu, positive and negative symptoms, cognitive symptoms, psychosis and schizophrenia in combination. "
5.	Seizures (Absence Seizure) 09/01/1987 - "Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid."

Related Drugs and Biologics

1.	Acids
2.	GABA Uptake Inhibitors
3.	Carboxylic Acids
4.	piperidine
5.	Arecoline (Arecolin)
6.	arecaidine
7.	guvacoline
8.	Alkaloids
9.	N-nitrosoguvacoline
10.	nipecotic acid