lobenzarit

prevents autoimmune kidney disease in hybrid mice; RN given refers to parent cpd

Also Known As:

2-((2-carboxyphenyl)amino)-4-chlorobenzoic acid; 4-chloro-2,2'-iminodibenzoic acid; CCA lobenzarit; N-(2-carboxyphenyl)-4-chloroanthranilic acid; disodium 4-chloro-2,2'-iminodibenzoate; lobenzarit disodium; lobenzarit sodium; lobenzarit, disodium salt; lobenzart; Benzoic acid, 2-((2-carboxyphenyl)amino)-4-chloro-, disodium salt

Networked: 29 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        lobenzarit: 29
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        lobenzarit: 29

Experts

1.	Whitehouse, Michael W: 1 article (01/2005)
2.	Kumagai, Norio: 1 article (08/2002)
3.	Ono, Koji: 1 article (08/2002)
4.	Sakai, Yoko: 1 article (08/2002)
5.	Wakamatsu, Shingo: 1 article (08/2002)

Related Diseases

1.	Myocarditis (Carditis) 02/01/1993 - "The aim was to test the efficacy of the immune system modulator lobenzarit disodium in the treatment of coxsackievirus B3 myocarditis. " 02/01/1993 - "Enhancement of coxsackievirus B3 myocarditis in mice by lobenzarit disodium through inhibition of splenic pan T cells." 08/01/1992 - "Effects of lobenzarit on murine acute viral myocarditis." 01/01/1993 - "The aim of this study is to test the therapeutic efficacy of immunomodulation with lobenzarit disodium (CCA) upon coxsackievirus B3 (CB3) myocarditis. " 02/01/1993 - "Lobenzarit disodium decreased splenic pan T cells and aggravated both clinical course and cardiac pathology in acute murine coxsackievirus B3 myocarditis."
2.	Inflammation (Inflammations) 01/01/1995 - "Lobenzarit disodtulIl (CCA) is a novel immunomodulatory drug useful in the treatment of chronic inflammations. " 01/01/2005 - "Drugs to treat inflammation are discussed under the following headings: (1) random discoveries covering copper, salicylates, heterocyclic diones, ACTH, adrenal steroids and disease-modifying agents (DMARDs); these include Au(I)-thiolates, chloroquine, and hydroxychloroquine, minocycline, cyclosporin, salazopyrine, D-penicillamine and methotrexate; (2) programmed NSAID developments covering salicylates and fenamates, arylalkanoates, diones, non-acidic NSAIDs, clozic, lobenzarit and coxibs; (3) synthetic glucocorticosteroids; and (4) 'Biologicals' for neutralising pro-inflammatory cytokines. "
3.	Rheumatoid Arthritis 02/01/1999 - "Lobenzarit disodium is a drug for the treatment of rheumatoid arthritis. " 02/01/1992 - "Lobenzarit (disodium 4-chloro-2,2'-iminodibenzoate [CCA]) is a novel disease-modifying drug for the treatment of rheumatoid arthritis (RA). " 02/01/1996 - "Nephrogenic diabetes insipidus (NDI) occurred in a 43-year-old woman who had received lobenzarit disodium for the treatment of rheumatoid arthritis (RA). " 02/01/1996 - "Nephrogenic diabetes insipidus induced by lobenzarit disodium treatment in patients with rheumatoid arthritis." 08/01/1992 - "[Lobenzarit disodium (CCA)--induced diabetes insipidus in a patient with rheumatoid arthritis]."
4.	Arthritis (Polyarthritis) 01/01/1986 - "Immunopharmacological study of CCA (Lobenzarit disodium), an anti-arthritis agent--I. Abrogation of IL 1 secretion by LPS-stimulated human monocytes and induction of gamma-interferon production with CCA." 04/01/1996 - "Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production." 01/01/1981 - "Depressed natural killer activity in rheumatoid arthritis and its in vitro augmentation with interferon and N-(2-carboxyphenyl)-4-chloroanthranilic acid disodium salt (CCA), an anti-arthritis agent." 07/01/1995 - "The effects of Ta-383 (0.016, 0.08, 0.4, 2 and 10 mg/kg) and anti-rheumatic drugs (lobenzarit 10 and 50 mg/kg, dexamethasone 0.25 mg/kg) were evaluated on type II collagen-induced arthritis in DBA/1J mice. " 01/01/1991 - "The effects of anti-rheumatic drugs (lobenzarit (CCA); 10 and 50mg/kg, cyclophosphamide (CP); 5 mg/kg and dexamethasone (DM); 0.25mg/kg) were evaluated immunologically and histopathologically on DBA/1J mice that develop polyarthritis after immunization by the intradermal injection of type II collagen. "
5.	Glomerulonephritis 12/01/1987 - "In this study, we examined the effect of an immunoregulatory antirheumatic agent, lobenzarit disodium (CCA), on spontaneously developing glomerulonephritis in MRL/Mp-lpr/lpr (MRL/l) mice. "

Related Drugs and Biologics

1.	Immunologic Factors (Immunomodulators)
2.	Antirheumatic Agents (DMARD)
3.	Cyclosporine (Ciclosporin)
4.	Interferon-gamma (Interferon, gamma)
5.	Immunosuppressive Agents (Immunosuppressants)
6.	3-chloro-4,4-dimethyl-2-oxazolidinone (agent I)
7.	traxanox
8.	mizoribine
9.	Collagen Type II (Type II Collagen)
10.	Cytokines

Related Therapies and Procedures

1.	Immunomodulation
2.	Therapeutics
3.	Intradermal Injections