agaritine

05/01/2007 - "It has been observed thru an extensive docking study that some of agaritine derivatives had markedly stronger binding interaction with the HIV protease than agaritine, suggesting that these derivatives might be good candidates for developing drugs for AIDS therapy."

05/01/2011 - "This is the first report suggesting that the anti-tumor effect of agaritine is mediated through apoptosis. "
07/01/2010 - "The results indicate that agaritine from ABM has direct anti-tumor activity against leukemic tumor cells in vitro. "
07/01/2010 - "Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells."
11/01/1998 - "The cumulative lifetime cancer risk of agaritine consumption in mushrooms is estimated to lie at approximately 10(-5)."
04/01/1995 - "Using a previously derived quantitative correlation between mutagenicity in the lacI test and carcinogenic potency, the carcinogenicity of agaritine in mushrooms was estimated: the average Swiss mushroom consumption of 4 g/day would be expected to contribute a lifetime cumulative cancer risk of about two cases per 100,000 lives."

03/01/2008 - "The concentration gradually decreased and returned to the basal level in 100 min. The maximum concentration, the time to the maximum concentration, and the half life were 0.37 microg/ml plasma, 0.33 h, and 0.71 h, respectively after administration of agaritine at 40 mg/kg body weight. "
11/01/1998 - "14C-Ring-labelled agaritine was administered orally to eight C57BL/6 mice at a chemical dose of 7.5 mg and radioactive dose of 1.2 x 10(9) dpm/kg body weight. "
04/01/1995 - "The corresponding daily doses of agaritine were 30 (averaged over the whole week), 80 and 120 mg/kg body weight, respectively. "
11/25/1997 - "The intake of the mushroom diets was equivalent to an intake of agaritine, the major phenylhydrazine derivative occurring in the mushroom, of 92 or 166 mg/kg body weight per day. "

06/01/1990 - "2) The observed rates of mouse urinary bladder carcinoma were 30.8% for fresh mushrooms (Agaricus bisporus), 23.5% for fresh Shiitake (Agaricus edodes), 9.8% for dry Shiitake, 50% for synthesized Agaritine and 5.4% for paraffin wax as a control. "