HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

brimonidine (Alphagan)

Subscribe to New Research on brimonidine

related to donidine; RN given refers to parent cpd; structure

Also Known As:

Alphagan; brimonidine tartrate; 5-bromo-6-(imidazolidinylideneamino)quinoxaline; 5-bromo-6-(imidazolin-2-ylamino)quinoxaline; AGN 190342; AGN-190342; Allergan brand of brimonidine tartrate; Pharm-Allergan brand of brimonidine tartrate; Ratiopharm brand of brimonidine tartrate; UK 14,304; UK 14,304-18; UK 14304; UK 14308; UK-14,304-18; UK-14,308; UK-14304; brimonidine Purite; brimonidine tartrate (1:1); brimonidine tartrate (1:1), (S-(R*,R*))-isomer; brimonidine tartrate, (R-(R*,R*))-isomer; bromoxidine; ratio-Brimonidine; 6-quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-

Networked: 439 relevant articles (67 outcomes, 105 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Quinoxalines: 14
    - brimonidine: 439

Experts

1.	Stewart, W C: 10 articles (11/2008 - 06/2000)
2.	Day, D G: 7 articles (01/2005 - 06/2000)
3.	Vidal-Sanz, Manuel: 6 articles (01/2014 - 02/2002)
4.	Hollander, David A: 6 articles (05/2012 - 05/2008)
5.	Katz, L Jay: 6 articles (05/2012 - 04/2002)
6.	Stewart, J A: 6 articles (01/2005 - 06/2000)
7.	Cantor, Louis B: 5 articles (07/2009 - 06/2002)
8.	Stewart, William C: 5 articles (04/2005 - 06/2002)
9.	Sharpe, E D: 5 articles (01/2005 - 06/2000)
10.	Holmes, K T: 5 articles (06/2001 - 06/2000)

Related Diseases

1.	Glaucoma 10/01/2011 - "Brimonidine, an alpha-2 adrenoceptor agonist, is an effective and safe medication that is widely used in glaucoma treatment. " 12/01/2005 - "Although brimonidine is effective in lowering IOP in children, alternative glaucoma therapy should be considered especially in children weighing <20 kg and those younger than 6 years." 04/01/2000 - "This study indicates that 0.2% brimonidine acutely associated with beta-blockers is an interesting new combination treatment useful in the management of glaucoma." 12/01/2005 - "To investigate brimonidine-related side effects and the efficacy of brimonidine in lowering intraocular pressure (IOP) in children with primary infantile and secondary glaucoma. " 12/01/2003 - "Glaucoma patients exhibit improved CS on initiation of brimonidine therapy."
2.	Ocular Hypertension (Glaucoma, Suspect) 06/01/2014 - "The effects of brimonidine on daytime and nighttime intraocular pressure (IOP) and aqueous humor dynamics were evaluated in volunteers with ocular hypertension (OHT). " 06/01/2014 - "Daytime and nighttime effects of brimonidine on IOP and aqueous humor dynamics in participants with ocular hypertension." 03/01/2006 - "[Ocular hypertension in children treated with brimonidine 0.2%. " 11/01/2001 - "To examine the neuroprotective effect of the alpha(2)-adrenergic agonist brimonidine in a chronic ocular hypertension model. " 12/01/1998 - "Eighteen patients with ocular hypertension were enrolled in a prospective, randomized, double-masked study in which 0.2% brimonidine tartrate, administered twice daily, was compared with its vehicle in a crossover fashion. "
3.	Open-Angle Glaucoma (Glaucoma, Open Angle) 09/01/2001 - "The purpose of this study was to report the acute and chronic effects of brimonidine 0.2% on intraocular pressure (IOP) and pulsatile ocular blood flow (pOBF) in patients with primary open-angle glaucoma (POAG). " 01/01/2015 - "A 78-year-old male with a history of primary open angle glaucoma presented with symptoms of unilateral blurry vision, irritation, and redness shortly after starting brimonidine exclusively in the right eye. " 04/01/2011 - "Sustained release ocular inserts of brimonidine tartrate for better treatment in open-angle glaucoma." 04/01/2004 - "To compare the efficacy and safety of unoprostone versus brimonidine both given twice daily in ocular hypertensive or primary open-angle glaucoma subjects. " 12/01/2003 - "Short posterior ciliary artery, central retinal artery, and choroidal hemodynamics in brimonidine-treated primary open-angle glaucoma patients."
4.	Erythema 09/01/2015 - "Brimonidine gel is a highly selective α2-adrenergic receptor agonist with potent vasoconstrictive effects, which leads to significant reduction of persistent facial erythema in the majority of patients when applied once daily. " 08/01/2015 - "A detailed analysis of adverse events is needed to accurately define worsening erythema and the adverse-events profile associated with brimonidine gel treatment. " 01/01/2015 - "For example, real-world use has shown that a percentage of patients (in our experience, approximately 10 to 20%) treated with brimonidine experience a worsening of erythema that has been called "rebound." Our routine use of this agent for >1 year has yielded strategies to set patient expectations, optimize treatment initiation, and minimize potential problems; this article details those strategies. " 05/01/2014 - "Brimonidine, which was US FDA approved last year and recently sanctioned by Health Canada, has filled an essential therapeutic void in the targeted treatment of diffuse facial erythema. " 05/01/2014 - "Brimonidine effective but may lead to significant rebound erythema."
5.	Rosacea (Acne Rosacea) 07/01/2014 - "Few studies have looked at the effectiveness of the novel treatment, brimonidine topical gel 0.33%, trademark name Mirvaso®, in the treatment of rosacea. " 09/30/2015 - "Recently, brimonidine - a selective α2-receptor-agonist which causes vasoconstriction of small cutaneous vessels - was approved for the treatment of erythemato-telangiectatic rosacea. " 01/01/2015 - "The role of brimonidine tartrate gel in the treatment of rosacea." 01/01/2015 - "The first available pharmacologic treatment to address the redness associated with rosacea is topical brimonidine. " 01/01/2015 - "Optimizing the use of topical brimonidine in rosacea management: panel recommendations."

Related Drugs and Biologics

1.	dorzolamide (Trusopt)
2.	Timolol (Blocadren)
3.	latanoprost (Xalatan)
4.	brinzolamide (Azopt)
5.	Betaxolol (Kerlon)
6.	Adrenergic Agonists (Adrenergic Receptor Agonist)
7.	brimonidine (Alphagan)
8.	Retinaldehyde (Retinal)
9.	travoprost (Travatan)
10.	Adrenergic alpha-Agonists (Adrenergic alpha-Agonist)

Related Therapies and Procedures

1.	Phacoemulsification
2.	Topical Administration
3.	Lasers (Laser)
4.	Ambulatory Surgical Procedures (Outpatient Surgery)
5.	Laser In Situ Keratomileusis (LASIK)