delta-1-pyrroline-5-carboxylate

(L)-isomer is the biologically active form; RN given refers to cpd without isomeric designation; structure

Also Known As:

1-pyrroline-5-carboxylate; delta(1)pyrroline-5-carboxylate; delta-1-pyrroline-5-carboxylate, (+-)-isomer; delta-1-pyrroline-5-carboxylate, 14C-labeled, (+-)-isomer; delta-1-pyrroline-5-carboxylic acid; pyrroline-5-carboxylate

Networked: 71 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - delta-1-pyrroline-5-carboxylate: 71

Experts

1.	Xiao, Shiyu: 2 articles (01/2022 - 08/2020)
2.	Zhou, Liya: 2 articles (01/2022 - 08/2020)
3.	Liu, Minghui: 2 articles (12/2021 - 01/2019)
4.	Luo, Jianyuan: 2 articles (12/2021 - 01/2019)
5.	Lin, Dar-Shong: 2 articles (01/2019 - 12/2018)
6.	Berardi, Alberto: 1 article (09/2022)
7.	Bertucci, Emma: 1 article (09/2022)
8.	Cavalleri, Francesca: 1 article (09/2022)
9.	Cinelli, Giulia: 1 article (09/2022)
10.	Fischer-Zirnsak, Björn: 1 article (09/2022)

Related Diseases

1.	Neoplasms (Cancer) 08/25/1983 - "Since the P-Rib-PP-dependent activation of these chemotherapeutic agents may be important to their clinical effectiveness, the events initiated by pyrroline-5-carboxylate may provide new insight into the nature of tumor sensitivity and resistance to these agents." 01/01/2022 - "Transformer2A (TRA2A) and Pyrroline-5-carboxylate reductase 2 (PYCR2) are related to cancer development and are overexpressed in many cancer cells. " 01/01/2022 - "Pyrroline-5-carboxylate reductase 1 (PYCR1) plays an important role in tumor development. " 01/01/2021 - "Pyrroline-5-carboxylate reductase 1 (PYCR1) plays a significant role in the malignant progression of various cancers. " 10/16/2019 - "Pyrroline-5-carboxylate reductase 1 (PYCR1) plays a critical role in metabolic profiles of tumors. "
2.	recessive Cutis laxa 09/01/2022 - "Autosomal recessive cutis laxa type IIIA is a very rare genetic condition, caused by pathogenic variants in ALDH18A1, encoding delta-1-pyrroline-5-carboxylate synthase (P5CS). " 12/01/2018 - "A study of pyrroline-5-carboxylate reductase 1 (PYCR1) deficiency, which causes a progeroid syndrome, may not only shed light on its genetic contribution to autosomal recessive cutis laxa (ARCL) but also help elucidate the functional mechanisms associated with aging. " 11/01/2013 - "Autosomal recessive cutis laxa type 2B (ARCL2B; OMIM # 612940) is a segmental progeroid disorder caused by mutations in PYCR1 encoding pyrroline-5-carboxylate reductase 1, which is part of the conserved proline de novo synthesis pathway. "
3.	Melanoma (Melanoma, Malignant) 05/01/2016 - "In the present study, we focused on the effect of pyrroline-5-carboxylate reductase-2 (PYCR2) on inducing autophagy process in melanoma. " 05/01/2016 - "Downregulation of pyrroline-5-carboxylate reductase-2 induces the autophagy of melanoma cells via AMPK/mTOR pathway." 01/01/2018 - "Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma."
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells." 01/01/2021 - "Overexpression of pyrroline-5-carboxylate reductase 1 (PYCR1) has been associated with the development of certain cancers; however, no studies have specifically examined the role of PYCR1 in hepatocellular carcinoma (HCC). "
5.	Adenocarcinoma of Lung 12/01/2022 - "LINC00511 aggravates the malignancy of lung adenocarcinoma through sponging microRNA miR-4739 to regulate pyrroline-5-carboxylate reductase 1 expression." 01/01/2019 - "The present study aimed to investigate the expression of pyrroline-5-carboxylate reductase 1 (P5CR1) protein in lung adenocarcinoma and paracancerous tissues and to explore the effect of silencing the encoding gene PYCR1 on the proliferation, migration, invasion, and cisplatin sensitivity in lung adenocarcinoma cells, thereby providing a novel therapeutic target for the treatment of the disease. "

Related Drugs and Biologics

1.	Oxidoreductases (Dehydrogenase)
2.	Proteins (Proteins, Gene)
3.	Cisplatin (Platino)
4.	Proline (L-Proline)
5.	Enzymes
6.	Proline Oxidase (Proline Dehydrogenase)
7.	Ornithine-Oxo-Acid Transaminase (Ornithine Aminotransferase)
8.	Ornithine
9.	MicroRNAs (MicroRNA)
10.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)

Related Therapies and Procedures

1.	Therapeutics