HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
oxiperomide
dopamine-blocking agent
Also Known As:
1-(1-(2-phenoxyethyl)-4-piperidyl)-2-benzimidazolone; R 4714; oxyperomide
Networked:
9
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzimidazoles: 245
oxiperomide: 9
Related Diseases
1.
Dyskinesias (Dyskinesia)
04/15/1978 - "
Effect of new dopamine-blocking agent (oxiperomide) on drug-induced dyskinesias in Parkinson's disease and spontaneous dyskinesias.
"
04/15/1978 - "
Oxiperomide also decreased spontaneous dyskinesias in those with tics and chorea and to a less extent in those with torsion dystonia, without necessarily causing Parkinsonism.
"
01/01/1981 - "
Acute dyskinesias, a neuroleptic-induced acute extrapyramidal syndrome, were elicited in squirrel monkeys by oxiperomide (1 mg/kg), tiapride (30 mg/kg), and halopemide (10 mg/kg).
"
01/01/1981 - "
Acute dyskinesias in monkeys elicited by halopemide, mezilamine and the "antidyskinetic" drugs, oxiperomide and tiapride.
"
06/15/1978 - "
The activities of oxiperomide and tiapride were compared with those of control "neuroleptic" agents in the dyskinesia model using 2-(N,N-dipropyl)amino-5,6-dihydroxytetralin to induce peri-oral movements, in order to determine whether the differential activities (oxiperomide and tiapride being comparatively more effective as antagonists) may involve striatal gabaminergic and serotonergic mechanisms.
"
2.
Parkinsonian Disorders (Parkinsonism)
04/15/1978 - "
Oxiperomide also decreased spontaneous dyskinesias in those with tics and chorea and to a less extent in those with torsion dystonia, without necessarily causing Parkinsonism.
"
03/01/1980 - "
Oxiperomide, a dopaminergic antagonist that has been shown to reduce levodopa-induced dyskinesias without producing an equal aggravation of Parkinsonism, was evaluated in a blind placebo-controlled trial in 10 patients with tardive dyskinesia.
"
3.
Tardive Dyskinesia
03/01/1980 - "
Although oxiperomide is only a palliative suppressing agent in tardive dyskinesia, as the symptoms returned when the drug was stopped, it is an interesting agent in the search for selective dopaminergic receptor blockers.
"
03/01/1980 - "
Oxiperomide in tardive dyskinesia.
"
01/01/1979 - "
Sulpiride and oxiperomide in tardive dyskinesia.
"
03/01/1980 - "
Oxiperomide, a dopaminergic antagonist that has been shown to reduce levodopa-induced dyskinesias without producing an equal aggravation of Parkinsonism, was evaluated in a blind placebo-controlled trial in 10 patients with tardive dyskinesia.
"
4.
Catalepsy
09/01/1975 - "
This was not due to a peculiar depressant effect of these agents in the guinea pig since haloperidol was shown to be equipotent to oxiperomide and of greater potency than pimozide both in causing catalepsy and antagonising amphetamine sterotypy...
"
11/01/1978 - "
The activity spectra of oxiperomide, spiroxatrine and analogues were determined in two experimental models of abnormal peri-oral movements (induced by intrastriatal dopamine and subcutaneously administered 2-(NN-dipropyl)amino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene (NN-diPr-5,6-diOHATN) in the guinea-pig), and in a stereotypy test (induced by subcutaneous apomorphine in the guinea-pig); the ability of the test compounds to induce catalepsy or catatonia in the rat was also determined.
"
5.
Tics (Tic)
04/15/1978 - "
Oxiperomide also decreased spontaneous dyskinesias in those with tics and chorea and to a less extent in those with torsion dystonia, without necessarily causing Parkinsonism.
"
Related Drugs and Biologics
1.
Dopamine Antagonists
2.
Levodopa (L Dopa)
3.
Tiapride Hydrochloride
4.
Antipsychotic Agents (Antipsychotics)
5.
Pimozide (Orap)
6.
Haloperidol (Haldol)
7.
Dopamine (Intropin)
8.
Dopamine Agonists (Dopamine Agonist)
9.
Sulpiride (neogama)
10.
Metoclopramide (Reglan)
Related Therapies and Procedures
1.
Intravenous Administration