glycylproline (Gly-Pro)

01/01/1990 - "The degradation of N-carbobenzoxy-gly-gly-arginine-AMC, L-arginine-AMC, glyproline-AMC, L-leucine-AMC, N-alpha-benzoyl-L-arginine-AMC, N-[p-toluenesulphonyl]-gly-pro-arginine-AMC, N-tert-butoxycarbonyl-leu-ser-thr-arginine-AMC, N-tert-butoxycarbonyl-ileu-glut-gly-arginine-AMC and N-tert-butoxycarbonyl-val-leu-lysine-AMC was significantly greater by fluid from the periodontitis group. "

01/01/1990 - "The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group. "

07/01/2012 - "It was found that 3-fold intranasal administration of Arg-Pro-Gly-Pro peptide in a dose of 1 mg/kg body weight under conditions of experimental persistent hyperglycemia prevents the development of diabetes in experimental rats and produces normoglycemic, anticoagulant, fibrinolytic, and antiplatelet effects."
05/01/1998 - "Anticoagulant, fibrinolytic, and fibrin-depolymerization effects were revealed during in vitro study of five proline-containing peptides (Gly-Pro, Trp-Pro, Pro-Gly, Gly-Pro-Gly-Gly, and Pro-Gly-Pro) in the concentration range 10(-9) to 10(-1) mg/ml. Intravenous injection of Trp-Pro and Pro-Gly into white rats at 250 micrograms/kg body weight significantly increased recalcification time and activated partial thromboplastin time of serum coagulation, increased fibrinolytic activity, decreased the level of serum factor XIII/(/)a and fibrinogen, and reduced thrombocyte aggregation. "

10/01/2013 - "This peptide with an amino sequence Val-Glu-Cys-Tyr-Gly-Pro-Asn-Arg-Pro-Gln-Phe was further examined for its potential in preventing atherosclerosis in this study. "

09/25/2003 - "The optimized method was applied to real samples and revealed a significant increase of intracellular Gly-Pro dipeptide in prolidase deficiency fibroblasts with respect to the control."
09/25/2003 - "A capillary electrophoresis (CE) method has been developed and optimized for the detection of Gly-Pro dipeptide in complex biological samples: medium, cell layer and matrix obtained from long term cultured human fibroblasts of control and prolidase deficiency patients. "
09/25/2003 - "Optimization of a capillary electrophoretic method to detect and quantify the Gly-Pro dipeptide in complex matrices from long term cultured prolidase deficiency fibroblasts."
02/01/1992 - "A case is reported of a 15-year-old boy with prolidase deficiency and marked urinary excretion of the iminodipeptide gly-pro. "
01/01/1985 - "In two unrelated cases of prolidase deficiency, fibroblast peak I was markedly reduced, although still detectable, whereas peak II was active against all the substrates, except for a 90% reduction against glycyl-L-proline. "