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etozolin
RN given refers to parent cpd; structure
Also Known As:
Elkapin; Go-687; etozolin monohydrochloride; ethyl (3-methyl-4-oxo-5-piperidinothiazolidin-2-ylidene)acetate
Networked:
12
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
etozolin: 12
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
etozolin: 12
Related Diseases
1.
Heart Failure
04/03/1981 - "
[Effect of etozolin on the blood coagulation and fibrinolysis system and on clinical parameters in patients with hypertension and heart failure].
"
04/20/1979 - "
[Studies on the diuretic effects of etozolin (Elkapin) in heart failure - a comparison with the loop diuretic agent furosemide (author's transl)].
"
2.
Hypertension (High Blood Pressure)
07/01/1990 - "
[Arterial hypertension in perimenopausal women; tolerability of etozolin].
"
01/01/1988 - "
[Etozolin in the treatment of essential arterial hypertension of mild-to-moderate degree].
"
04/03/1981 - "
[Effect of etozolin on the blood coagulation and fibrinolysis system and on clinical parameters in patients with hypertension and heart failure].
"
01/01/1977 - "
Due to its long-lasting action etozolin seems particularly indicated for the treatment of cardiac and renal edema as well as for the treatment of hypertension.
"
07/01/1990 - "
Twenty women aged 45-55 years with mild-moderate hypertension were treated for 12 months with etozolin, a new loop diuretic.
"
3.
Essential Hypertension
02/15/1990 - "
The above research was aimed to evaluating the effects of etozolin, captopril and their combination in a group of 30 patients with essential hypertension; age range 42-74 years, average 76.6.
"
12/01/1989 - "
Etozolin monotherapy and combination with verapamil in essential hypertension.
"
12/01/1989 - "
A total of 1337 patients with mild to moderate essential hypertension were included in an open, multicentre trial to assess the response rate to the diuretic etozolin (200 mg once a day) and to verify whether the addition of the calcium antagonist verapamil (120 mg twice a day) in non-responders may have a favourable effect.
"
4.
Renal Insufficiency (Renal Failure)
01/01/1980 - "
It is concluded that in the single dose experiments renal insufficiency does not significantly influence the metabolization of etozolin and ozolinone.
"
01/01/1980 - "
Even in severe renal insufficiency the HL of etozolin and ozolinone did not differ from normal values, the mean HL of etozolin being 2.8 +/- 0.4 h and of ozolinone being 10.2 +/- 1.5 h.
"
5.
Liver Cirrhosis (Hepatic Cirrhosis)
12/01/1987 - "
The single dose kinetics of (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (etozolin) and its active metabolite ozolinone were determined in 6 healthy volunteers, in 12 patients with acute hepatitis and in 15 patients with hepatic cirrhosis with ascites.
"
12/01/1987 - "
Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites.
"
Related Drugs and Biologics
1.
etozolin
2.
Diuretics
3.
Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)
4.
Furosemide (Lasix)
5.
ozolinone
6.
Verapamil (Calan)
7.
Electrolytes
8.
Creatinine
9.
Captopril (Capoten)
10.
Calcium