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dipivefrin (Propine)

used in treatment of both primary & open angle glaucoma; RN given refers to (+-)-isomer

Also Known As:

Propine; Alcon brand of dipivefrin hydrochloride; Allergan brand of dipivefrin hydrochloride; Apo-Dipivefrin; Apotex brand of dipivefrin hydrochloride; Diopine; Dipoquin; Glaucothil; Glaudrops; Ioquin brand of dipivefrin hydrochloride; PMS-Dipivefrin; Pharm-Allergan brand of dipivefrin hydrochloride; Pharmascience brand of dipivefrin hydrochloride; Ratiopharm brand of dipivefrin hydrochloride; adrenaline dipivalate; d Epifrin; dipivaloylepinephrine; dipivalyl epinephrine; dipivefrin acetate, (+-)-isomer; dipivefrin citrate (1:1), (+-)-isomer; dipivefrin hydrochloride; dipivefrin hydrochloride, (+-)-isomer; dipivefrin monophosphate, (+-)-isomer; dipivefrin monosulfate, (+-)-isomer; dipivefrin nitrate, (+-)-isomer; dipivefrin perchlorate; dipivefrin propanoate, (+-)-isomer; dipivefrin tartrate (1:1), (+-)-(R-(R*,R*))-isomer; dipivefrin tartrate (1:1), (R)-(R-(R*,R*))-isomer; dipivefrin, (R)-isomer; ratio-Dipivefrin; Propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, (+-)-

Networked: 53 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
- Alcohols: 387
  - Amino Alcohols: 14
    - Ethanolamines: 12
      - Epinephrine: 10233
        dipivefrin: 53

Experts

1.	Cantor, Louis B: 1 article (09/2011)
2.	Arthur, Stella: 1 article (09/2011)
3.	Nakamura, Masatsugu: 1 article (10/2009)
4.	Ishida, Naruhiro: 1 article (10/2009)
5.	Odani-Kawabata, Noriko: 1 article (10/2009)
6.	Akaishi, Takahiro: 1 article (10/2009)
7.	Denis, P: 1 article (07/2008)
8.	Aptel, F: 1 article (07/2008)
9.	Pesquero, João B: 1 article (11/2003)
10.	Fausto, Daniela M: 1 article (11/2003)

Related Diseases

1.	Open-Angle Glaucoma (Glaucoma, Open Angle) 02/01/1985 - "Large bulbar conjunctival follicles developed in 12 patients who received dipivefrin therapy for prolonged periods in the management of chronic open-angle glaucoma. " 01/01/2000 - "[Therapy of primary open-angle glaucoma by oftan-dipivefrin]." 03/01/1981 - "Fourteen patients with open-angle glaucoma applied one drop 0.1% dipivalyl epinephrine topically twice daily for three years. " 07/01/1979 - "[The pressure reducing effects of pilocarpin in combination with Dipivalyl-epinephrine in glaucoma simplex (author's transl)]." 04/01/1978 - "Our open-label investigation included the administration of dipivalyl epinephrine ophthalmic solution to the eyes of 33 patients with an open-angle glaucoma. "
2.	Ocular Hypertension (Glaucoma, Suspect) 12/01/1979 - "Of 26 patients enrolled in a study designed to assess the usefulness of dipivalyl epinephrine 0.1%, administered topically at 12-hour intervals, for lowering intraocular pressure in patients with glaucoma and ocular hypertension, six patients (23.1%) developed adverse external ocular side effects severe enough to require that the drug be discontinued. " 11/01/1980 - "The availability of dipivalyl epinephrine (DPE) may decidedly shift the balance of the treatment of ocular hypertension, when indicated, to an epinephrine compound." 08/01/1983 - "As sole therapy dipivalyl epinephrine was effective in chronic simple open-angle glaucoma, ocular hypertension and pseudoexfoliative glaucoma, and may be useful on its own in the latter two conditions. " 11/01/1994 - "The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension." 03/01/1994 - "The effect of 0.1% dipivalyl epinephrine on intraocular pressure was compared with 1% epinephrine in patients with primary open-angle glaucoma or ocular hypertension. "
3.	Glaucoma 03/01/1978 - "Dipivalyl epinephrine: a new pro-drug in the treatment of glaucoma." 12/01/1979 - "Of 26 patients enrolled in a study designed to assess the usefulness of dipivalyl epinephrine 0.1%, administered topically at 12-hour intervals, for lowering intraocular pressure in patients with glaucoma and ocular hypertension, six patients (23.1%) developed adverse external ocular side effects severe enough to require that the drug be discontinued. " 08/01/1990 - "A report is given on an 83-year-old female who acquired central vein thrombosis in her seeing eye one day after having started topical medication with dipivalyl epinephrine for advanced glaucoma discovered in the other eye. " 01/01/1988 - "Follicular conjunctivitis on Dipivefrin therapy for glaucoma." 04/01/1978 - "[Clinical studies conducted with a new epinephrine derivative for the treatment of glaucoma (Dipivalyl epinephrine)]."
4.	Neuroblastoma 06/01/2003 - "In the present study, we investigated various commercial antiglaucoma drugs including timolol (0.58 microM to 58 microM), betaxolol (1.62 microM to 162 microM), carteolol (6.8 microM to 680 microM), pilocarpine (4.08 microM to 408 microM), latanoprost (0.01 microM to 1.1 microM), dorzolamide (6.16 microM to 616 microM), brinzolamide (2.6 microM to 260 microM), brimonidine (0.68 microM to 68 microM), dipivefrin (0.28 microM to 28 microM) and preservative benzalkonium chloride on their effects to inhibit glutamate-induced intracellular free Ca(2+) ([Ca(2+)](i)) increase in cultured N1E-115 neuroblastoma cells. "
5.	Macular Edema 11/01/1982 - "Cystoid macular edema presumably induced by dipivefrin hydrochloride (Propine)" 05/01/1999 - "In these seven patients, the following coexisting ocular conditions may have placed these eyes at risk for prostaglandin-mediated blood-retinal barrier vascular insufficiency: history of dipivefrin-associated CME, epiretinal membrane, complicated cataract surgery, history of macular edema associated with branch retinal vein occlusion, history of anterior uveitis, and diabetes mellitus. " 07/01/2008 - "A review of the literature suggests that most PGA-treated eyes with CME had independent risk for development of CME, with a disruption of the blood-aqueous barrier: open or absent posterior capsule, history of dipivefrin-associated CME, epiretinal membrane, complicated cataract surgery, history of macular edema associated with branch retinal vein occlusion, ocular inflammation, and diabetes mellitus. "

Related Drugs and Biologics

1.	moprolol (levomoprolol)
2.	Epinephrine (Adrenaline)
3.	Timolol (Blocadren)
4.	dipivefrin (Propine)
5.	Pilocarpine (Ocusert)
6.	Betaxolol (Kerlon)
7.	Ophthalmic Solutions (Eye Drops)
8.	latanoprost (Xalatan)
9.	dorzolamide (Trusopt)
10.	brimonidine (Alphagan)