arsenite

01/01/2009 - "These findings may help to explain how arsenite, by decreasing generation of the tumor suppressor Notch1, contributes to skin carcinogenesis."
06/01/1997 - "This finding may help to explain why rodents do not develop tumors after exposure to arsenite, while humans do. "
01/01/2016 - "Previous studies reported that arsenite exposure of only F0 females during their pregnancy increases hepatic tumors in the F1 males in C3H mice, whose males are predisposed spontaneously to develop hepatic tumors later in life. "
09/01/2013 - "Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner. "
05/01/2007 - "Additionally, studies have demonstrated the pro-angiogenic effect of arsenite and its potential promotion of tumor angiogenesis and tumor progression. "

11/01/2000 - "Arsenite treatment has been found to induce clinical remission in patients with acute promyelocytic leukemia. "
12/01/2006 - "Although inorganic arsenite (As(III)) is toxic in humans, it has recently emerged as an effective chemotherapeutic agent for acute promyelocytic leukemia (APL). "
04/30/2002 - "These results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenite as a human toxin and carcinogen, as well as its efficacy as a chemotherapeutic agent for acute promyelocytic leukemia."
01/01/2016 - "Although arsenic trioxide (arsenite, AsIII) has shown a remarkable efficacy in the treatment of acute promyelocytic leukemia patients, multidrug resistance is still a major concern for its clinical use. "
07/01/2015 - "Delphinidin induces cytotoxicity and potentiates cytocidal effect in combination with arsenite in an acute promyelocytic leukemia NB4 cell line."

12/01/2007 - "Our data indicate that NAC is potentially therapeutic for arsenite-induced peripheral neuropathy."
04/15/2008 - "Glial-cell-derived neurotrophic factor appears to be protective against arsenite-induced peripheral neuropathy."
01/01/2009 - "Our data suggest that melatonin is potentially a therapy for arsenite-induced peripheral neuropathy."

04/15/2010 - "In this study, we have disclosed that arsenite effectively induces the apoptotic response in the HepG2 human hepatoma cells by triggering GADD45alpha induction and the subsequent activation of JNKs/AP-1 cell death pathway. "
12/01/2011 - "IKKβ downregulation is critical for triggering JNKs-dependent cell apoptotic response in the human hepatoma cells under arsenite exposure."
04/15/2010 - "Our results thus have illustrated the selective pro-apoptotic role of arsenite in the hepatoma cells by activating GADD45alpha-dependent cell death pathway whereas with little effect on the normal hepatic cells. "
04/15/2010 - "GADD45alpha mediates arsenite-induced cell apoptotic effect in human hepatoma cells via JNKs/AP-1-dependent pathway."
02/01/2004 - "We have reported that brief exposure of pregnant C3H mice to arsenite in their drinking water during gestation induced hepatocellular carcinoma (HCC) in male offspring after they became adults. "

01/24/2014 - "STMN was phosphorylated on Ser-38 and Ser-63 in response to hyperosmolarity, heat shock, and arsenite treatment but rapidly dephosphorylated after oxidative stress treatment. "
09/06/2013 - "We also showed that the level of the α-N-methylation was stimulated in cells in response to a variety of extracellular stimuli, including increased cell density, heat shock, and arsenite treatment, although the methylation level was not altered upon metaphase arrest. "
07/01/2012 - "Heat shock factor 1 (HSF1) is a key regulator of the cytoprotective and anti-apoptotic heat shock response and can be activated by arsenite. "
10/01/2009 - "We report that Drosophila cells form SGs in response to arsenite and heat shock. "
08/01/2008 - "The phosphorylated HSP27 isoform which increased in EBV(+) cells can be induced by both heat shock and arsenite. "